Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jack A, Connolly"'
Autor:
Andrew Yiakoumetti, Erik K. R. Hanko, Yutong Zou, Jeremy Chua, Jakub Chromy, Ruth A. Stoney, Kris Niño G. Valdehuesa, Jack A. Connolly, Cunyu Yan, Katherine A. Hollywood, Eriko Takano, Rainer Breitling
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Flavones and flavonols are important classes of flavonoids with nutraceutical and pharmacological value, and their production by fermentation with recombinant microorganisms promises to be a scalable and economically favorable alternative to extracti
Externí odkaz:
https://doaj.org/article/83c42ded606b490f979c0ec13d7b407f
Autor:
Emily Abraham, Hannah A. Lawther, Yunpeng Wang, Joseph S. Zarins-Tutt, Gerry Sann Rivera, Chengcang Wu, Jack A. Connolly, Gordon Florence, Matthias Agbo, Hong Gao, Rebecca J. M. Goss
Publikováno v:
Biomolecules, Vol 14, Iss 1, p 117 (2024)
With the rise in antimicrobial resistance, there is an urgent need for new classes of antibiotic with which to treat infectious disease. Marinomycin, a polyene antibiotic from a marine microbe, has been shown capable of killing methicillin-resistant
Externí odkaz:
https://doaj.org/article/c05042324ae142e5b52bd795f44e21dd
Autor:
Michael J. Smanski, Eriko Takano, Linda L. Kinkel, Rainer Breitling, Jack A. Connolly, William R. Harcombe
Publikováno v:
Natural Product Reports. 39:311-324
Covering: Focus on 2015 to 2020Plant and soil microbiomes consist of diverse communities of organisms from across kingdoms and can profoundly affect plant growth and health. Natural product-based intercellular signals govern important interactions be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f2176d1f674be29a12b7b77c441988
https://doi.org/10.1039/d1np00034a
https://doi.org/10.1039/d1np00034a
Autor:
Xiaomeng Hao, Li-Yan Yu, Maoluo Gan, Rebecca J. M. Goss, Yufeng Liu, Shan Cen, Yujia Wang, Jack A. Connolly, Jiaqing Yu, Yu-Qin Zhang
Publikováno v:
Organic Letters. 22:9346-9350
Four unusual cyclopeptides, zelkovamycins B-E (1-4), were isolated from an endophytic Kitasatospora sp. Zelkovamycin B was featured by an unprecedented 3-methyl-5-hydroxypyrrolidine-2,4-dione ring system linked to the cyclopeptide skeleton. Their str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b9974d346d5186b3f81bf5d8fa3469e
https://doi.org/10.1021/acs.orglett.0c03565
https://doi.org/10.1021/acs.orglett.0c03565
Publikováno v:
Current Opinion in Chemical Biology. 58:A1-A3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::545045240da5f1e408dfa2cfc354ed77
https://doi.org/10.1016/j.cbpa.2020.11.001
https://doi.org/10.1016/j.cbpa.2020.11.001
Autor:
Yunpeng Wang, Stephen E. Shanahan, Richard J. K. Taylor, Rebecca J. M. Goss, Danai S. Gkotsi, Jack A. Connolly, Hannes Ludewig, Jagwinder Dhaliwal, Matthew M. W. McLachlan, William P. Unsworth, James H. Naismith, Sunil V. Sharma
We thank the European Research Council under the European Union’s Seventh Framework Programme (FP7/2007–2013/ERC grant agreement no. 614779 GenoChemetics to R.J.M.G.), Syngenta and Wellcome ISSF (grant no. 204821/Z/16/Z to D.S.G.) for generous fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee1f06dd85e509dccd214f98051dc7ff
https://eprints.whiterose.ac.uk/152554/1/Revised_VirX1_210619_1_WPU_edit_AAM.docx
https://eprints.whiterose.ac.uk/152554/1/Revised_VirX1_210619_1_WPU_edit_AAM.docx
Autor:
Danai S, Gkotsi, Hannes, Ludewig, Sunil V, Sharma, Jack A, Connolly, Jagwinder, Dhaliwal, Yunpeng, Wang, William P, Unsworth, Richard J K, Taylor, Matthew M W, McLachlan, Stephen, Shanahan, James H, Naismith, Rebecca J M, Goss
Publikováno v:
Nature chemistry. 11(12)
Oceanic cyanobacteria are the most abundant oxygen-generating phototrophs on our planet and are therefore important to life. These organisms are infected by viruses called cyanophages, which have recently shown to encode metabolic genes that modulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b425222cedf460f772354259d2108588
https://pubmed.ncbi.nlm.nih.gov/31758155
https://pubmed.ncbi.nlm.nih.gov/31758155
Autor:
Jack A, Connolly, Amber, Wilson, Malgorzata, Macioszek, Zhongshu, Song, Luoyi, Wang, Hadi H, Mohammad, Mukul, Yadav, Maura, di Martino, Claire E, Miller, Joanne, Hothersall, Anthony S, Haines, Elton R, Stephens, Matthew P, Crump, Christine L, Willis, Thomas J, Simpson, Peter J, Winn, Christopher M, Thomas
Publikováno v:
Scientific Reports
The mupirocin trans-AT polyketide synthase pathway, provides a model system for manipulation of antibiotic biosynthesis. Its final phase involves removal of the tertiary hydroxyl group from pseudomonic acid B, PA-B, producing the fully active PA-A in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::322599a316d1a6c01eee44f709a7fa47
https://pubmed.ncbi.nlm.nih.gov/30733464
https://pubmed.ncbi.nlm.nih.gov/30733464
Autor:
Joanne Hothersall, Zhongshu Song, Jack A. Connolly, Thomas J. Simpson, Peter J. Winn, Hadi H. Mohammad, Paul R. Race, Christine L. Willis, Christopher M. Thomas
Publikováno v:
Mohammad, H H, Connolly, J A, Song, Z, Hothersall, J, Race, P R, Willis, C L, Simpson, T J, Winn, P J & Thomas, C M 2018, ' Fine Tuning of Antibiotic Activity by a Tailoring Hydroxylase in a Trans-AT Polyketide Synthase Pathway ', ChemBioChem, vol. 19, no. 8, pp. 836-841 . https://doi.org/10.1002/cbic.201800036
The addition or removal of hydroxy groups modulates the activity of many pharmacologically active biomolecules. It can be integral to the basic biosynthetic factory or result from associated tailoring steps. For the anti-MRSA antibiotic mupirocin, re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d2026ceac28f9acda4ee2da1cf8ce8
http://www.scopus.com/inward/record.url?scp=85043569007&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85043569007&partnerID=8YFLogxK
Autor:
Ian R. Henderson, Stephen J. W. Busby, Rita E. Godfrey, Jack A. Connolly, Amanda E. Rossiter, Douglas F. Browning
Publikováno v:
Biochemical Journal. 466:323-335
Pet is a cytotoxic autotransporter protein secreted by the pathogenic enteroaggregative Escherichia coli strain 042. Expression of Pet is co-dependent on two global transcription regulators: CRP (cyclic AMP receptor protein) and Fis (factor for inver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13e2d13edab55f16e79f8715badb36a8
https://doi.org/10.1042/bj20141315
https://doi.org/10.1042/bj20141315