Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Jack A, Bryant"'
Autor:
Peter Wotherspoon, Hannah Johnston, David J. Hardy, Rachel Holyfield, Soi Bui, Giedrė Ratkevičiūtė, Pooja Sridhar, Jonathan Colburn, Charlotte B. Wilson, Adam Colyer, Benjamin F. Cooper, Jack A. Bryant, Gareth W. Hughes, Phillip J. Stansfeld, Julien R. C. Bergeron, Timothy J. Knowles
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The Maintenance of Lipid Asymmetry (Mla) pathway is a multicomponent system found in all gram-negative bacteria that contributes to virulence, vesicle blebbing and preservation of the outer membrane barrier function. It acts by removing ecto
Externí odkaz:
https://doaj.org/article/b7c3efd6199f407a8b00be9ac32695d5
Autor:
Jessica Gray, Von Vergel L Torres, Emily Goodall, Samantha A McKeand, Danielle Scales, Christy Collins, Laura Wetherall, Zheng Jie Lian, Jack A Bryant, Matthew T Milner, Karl A Dunne, Christopher Icke, Jessica L Rooke, Thamarai Schneiders, Peter A Lund, Adam F Cunningham, Jeff A Cole, Ian R Henderson
Publikováno v:
eLife, Vol 12 (2024)
Klebsiella pneumoniae is a global public health concern due to the rising myriad of hypervirulent and multidrug-resistant clones both alarmingly associated with high mortality. The molecular mechanisms underpinning these recalcitrant K. pneumoniae in
Externí odkaz:
https://doaj.org/article/cf25e48630df47d7b08338ad3b7a5d15
Autor:
Dema Alodaini, Victor Hernandez-Rocamora, Gabriela Boelter, Xuyu Ma, Micheal B. Alao, Hannah M. Doherty, Jack A. Bryant, Patrick Moynihan, Danesh Moradigaravand, Monika Glinkowska, Waldemar Vollmer, Manuel Banzhaf
Publikováno v:
mBio, Vol 15, Iss 4 (2024)
ABSTRACTGram-negative bacteria have a thin peptidoglycan layer between the cytoplasmic and outer membranes protecting the cell from osmotic challenges. Hydrolases of this structure are needed to cleave bonds to allow the newly synthesized peptidoglyc
Externí odkaz:
https://doaj.org/article/080075cfb5dc486fa815d81cbf3d3070
Autor:
Rowan Watson, Maria Maxwell, Sophie Dunn, Alexander Brooks, Long Jiang, Harriet J. Hill, Georgia Williams, Anna Kotowska, Naa Dei Nikoi, Zania Stamataki, Manuel Banzhaf, David Scurr, Jack Alfred Bryant, Felicity deCogan
Publikováno v:
Nano Select, Vol 4, Iss 7, Pp 442-453 (2023)
Abstract Microbial contamination of plastic surfaces is a significant source of hospital‐acquired infections. To produce antimicrobial surfaces, chlorhexidine was attached to nitrided acrylonitrile butadiene styrene (ABS). The uniformity of chlorhe
Externí odkaz:
https://doaj.org/article/4a58ea8f8c9b409b8b24d5dd28798652
Autor:
Rowan Watson, Morwenna Oldfield, Jack A. Bryant, Lily Riordan, Harriet J. Hill, Julie A. Watts, Morgan R. Alexander, Michael J. Cox, Zania Stamataki, David J. Scurr, Felicity de Cogan
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract The COVID-19 pandemic has demonstrated the real need for mechanisms to control the spread of airborne respiratory pathogens. Thus, preventing the spread of disease from pathogens has come to the forefront of the public consciousness. This ha
Externí odkaz:
https://doaj.org/article/909e89defe7944cbadddc06f56b02153
Autor:
Jack A. Bryant, Lily Riordan, Rowan Watson, Naa Dei Nikoi, Wioleta Trzaska, Louise Slope, Callum Tibbatts, Morgan R. Alexander, David J. Scurr, Robin C. May, Felicity de Cogan
Publikováno v:
Global Challenges, Vol 6, Iss 5, Pp n/a-n/a (2022)
Abstract There is an increasing focus in healthcare environments on combatting antimicrobial resistant infections. While bacterial infections are well reported, infections caused by fungi receive less attention, yet have a broad impact on society and
Externí odkaz:
https://doaj.org/article/0989afacced74b4fafa69aa1a02248d2
Autor:
C. Coral Domínguez-Medina, Marisol Pérez-Toledo, Anna E. Schager, Jennifer L. Marshall, Charlotte N. Cook, Saeeda Bobat, Hyea Hwang, Byeong Jae Chun, Erin Logan, Jack A. Bryant, Will M. Channell, Faye C. Morris, Sian E. Jossi, Areej Alshayea, Amanda E. Rossiter, Paul A. Barrow, William G. Horsnell, Calman A. MacLennan, Ian R. Henderson, Jeremy H. Lakey, James C. Gumbart, Constantino López-Macías, Vassiliy N. Bavro, Adam F. Cunningham
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
The O-antigen of LPS is known to limit the binding of antibody to bacterial surface antigens. Here the AUs show that the chemical and physical structure of the O-antigen are central factors in limiting the exposure of surface antigens to antibodies d
Externí odkaz:
https://doaj.org/article/5196a15dc94f4468af82d42ac9f3cb2e
Autor:
Claudia A. Freire, Rosa M. Silva, Rita C. Ruiz, Daniel C. Pimenta, Jack A. Bryant, Ian R. Henderson, Angela S. Barbosa, Waldir P. Elias
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Several strategies are used by Escherichia coli to evade the host innate immune system in the blood, such as the cleavage of complement system proteins by secreted proteases. Members of the Serine Proteases Autotransporters of Enterobacteriaceae (SPA
Externí odkaz:
https://doaj.org/article/d13a5be681f14514b95b50c5fe529ad0
Autor:
Emily C A Goodall, Georgia L Isom, Jessica L Rooke, Karthik Pullela, Christopher Icke, Zihao Yang, Gabriela Boelter, Alun Jones, Isabel Warner, Rochelle Da Costa, Bing Zhang, James Rae, Wee Boon Tan, Matthias Winkle, Antoine Delhaye, Eva Heinz, Jean-Francois Collet, Adam F Cunningham, Mark A Blaskovich, Robert G Parton, Jeff A Cole, Manuel Banzhaf, Shu-Sin Chng, Waldemar Vollmer, Jack A Bryant, Ian R Henderson
Publikováno v:
PLoS Genetics, Vol 17, Iss 12, p e1009586 (2021)
The cell envelope is essential for viability in all domains of life. It retains enzymes and substrates within a confined space while providing a protective barrier to the external environment. Destabilising the envelope of bacterial pathogens is a co
Externí odkaz:
https://doaj.org/article/ec2a22d24ae74fa89c1da995d1848199
Autor:
Christopher Icke, Freya J Hodges, Karthik Pullela, Samantha A McKeand, Jack Alfred Bryant, Adam F Cunningham, Jeff A Cole, Ian R Henderson
Publikováno v:
eLife, Vol 10 (2021)
Protein acylation is critical for many cellular functions across all domains of life. In bacteria, lipoproteins have important roles in virulence and are targets for the development of antimicrobials and vaccines. Bacterial lipoproteins are secreted
Externí odkaz:
https://doaj.org/article/b09b42d7284d412aa5219c5349c608ba