Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jack, Maung"'
Autor:
Jeffrey J. Jackson, Grant M. Shibuya, Buvana Ravishankar, Lavanya Adusumilli, Delia Bradford, Dirk G. Brockstedt, Cyril Bucher, Minna Bui, Cynthia Cho, Christoph Colas, Gene Cutler, Adrian Dukes, Xinping Han, Dennis X. Hu, Scott Jacobson, Paul D. Kassner, George E. Katibah, Michelle Yoo Min Ko, Urvi Kolhatkar, Paul R. Leger, Anqi Ma, Lisa Marshall, Jack Maung, Andrew A. Ng, Akinori Okano, Deepa Pookot, Daniel Poon, Chandru Ramana, Maureen K. Reilly, Omar Robles, Jacob B. Schwarz, Anton A. Shakhmin, Hunter P. Shunatona, Raashi Sreenivasan, Parcharee Tivitmahaisoon, Mengshu Xu, Thant Zaw, David J. Wustrow, Mikhail Zibinsky
Publikováno v:
Journal of Medicinal Chemistry. 65:12895-12924
General control nonderepressible 2 (GCN2) protein kinase is a cellular stress sensor within the tumor microenvironment (TME), whose signaling cascade has been proposed to contribute to immune escape in tumors. Herein, we report the discovery of cell-
Autor:
Paul D. Kassner, Dirk G. Brockstedt, David Wustrow, Jacob Schwarz, Christophe Colas, Jack Maung, Akinori Okano, Xinping Han, Nathan Kozon, Delia Bradford, Lisa A. Marshall, Silpa Suthram, Kyle Young, Betty Abraham, Deepa Pookot, Niket Shah, Jerick Sanchez, Steve T. Wong, Scott Jacobson, Cynthia Cho, Payal Rana, Berenger Biannic, Dennis X. Hu, Paul R. Leger, Gene Cutler, Michael T. Sun, Yamini M. Ohol
Genes whose expression is significantly altered upon USP7 inhibitor treatment of H526 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02f989ee2cc8256a47675f17613ed482
https://doi.org/10.1158/1535-7163.22518810
https://doi.org/10.1158/1535-7163.22518810
Autor:
Paul D. Kassner, Dirk G. Brockstedt, David Wustrow, Jacob Schwarz, Christophe Colas, Jack Maung, Akinori Okano, Xinping Han, Nathan Kozon, Delia Bradford, Lisa A. Marshall, Silpa Suthram, Kyle Young, Betty Abraham, Deepa Pookot, Niket Shah, Jerick Sanchez, Steve T. Wong, Scott Jacobson, Cynthia Cho, Payal Rana, Berenger Biannic, Dennis X. Hu, Paul R. Leger, Gene Cutler, Michael T. Sun, Yamini M. Ohol
The deubiquitinase USP7 regulates the levels of multiple proteins with roles in cancer progression and immune response. Thus, USP7 inhibition may decrease oncogene function, increase tumor suppressor function, and sensitize tumors to DNA-damaging age
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2553fdd80c98dcbf6dde06a2115d9b1f
https://doi.org/10.1158/1535-7163.c.6542127.v1
https://doi.org/10.1158/1535-7163.c.6542127.v1
Autor:
Paul D. Kassner, Dirk G. Brockstedt, David Wustrow, Jacob Schwarz, Christophe Colas, Jack Maung, Akinori Okano, Xinping Han, Nathan Kozon, Delia Bradford, Lisa A. Marshall, Silpa Suthram, Kyle Young, Betty Abraham, Deepa Pookot, Niket Shah, Jerick Sanchez, Steve T. Wong, Scott Jacobson, Cynthia Cho, Payal Rana, Berenger Biannic, Dennis X. Hu, Paul R. Leger, Gene Cutler, Michael T. Sun, Yamini M. Ohol
Gene sets significantly upregulated upon USP7 inhibitor treatment of H526 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::533cabf48658430126efa2dc00097d50
https://doi.org/10.1158/1535-7163.22518813
https://doi.org/10.1158/1535-7163.22518813
Autor:
Paul D. Kassner, Dirk G. Brockstedt, David Wustrow, Jacob Schwarz, Christophe Colas, Jack Maung, Akinori Okano, Xinping Han, Nathan Kozon, Delia Bradford, Lisa A. Marshall, Silpa Suthram, Kyle Young, Betty Abraham, Deepa Pookot, Niket Shah, Jerick Sanchez, Steve T. Wong, Scott Jacobson, Cynthia Cho, Payal Rana, Berenger Biannic, Dennis X. Hu, Paul R. Leger, Gene Cutler, Michael T. Sun, Yamini M. Ohol
Supplementary Figures S1-S6 and legends, and Tables S1, S2, S5, S6, S7.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::608a87c8b9624888e8b1c3a5ac3f572b
https://doi.org/10.1158/1535-7163.22518816.v1
https://doi.org/10.1158/1535-7163.22518816.v1
Autor:
Jacob Bradley Schwarz, Christophe Colas, Paul D. Kassner, Betty Abraham, Delia Bradford, Michael T. Sun, Lisa A. Marshall, Akinori Okano, Dennis X. Hu, Gene Cutler, Payal Rana, Paul Leger, David J. Wustrow, Cynthia Cho, Jack Maung, Yamini M. Ohol, Deepa Pookot, Nathan Kozon, Steve Wong, Scott Jacobson, Niket Shah, Berenger Biannic, Xinping Han, Silpa Suthram, Jerick Sanchez, Dirk G. Brockstedt, Kyle Young
Publikováno v:
Molecular Cancer Therapeutics. 19:1970-1980
The deubiquitinase USP7 regulates the levels of multiple proteins with roles in cancer progression and immune response. Thus, USP7 inhibition may decrease oncogene function, increase tumor suppressor function, and sensitize tumors to DNA-damaging age
Autor:
Deepa Pookot, Payal Rana, Paul D. Kassner, Christopher Higgs, Xinping Han, Berenger Biannic, Betty Abraham, Christophe Colas, Jacob Bradley Schwarz, Akinori Okano, Scott Jacobson, Paul Leger, Michael Sun, Jerick Sanchez, Emily Karbarz, Niket Shah, Cynthia Cho, Steve Wong, Yamini M. Ohol, Minna Bui, David J. Wustrow, Maksim Osipov, Delia Bradford, Dennis X. Hu, Jack Maung, Kyle Young, Dirk G. Brockstedt, Grant M. Shibuya
Publikováno v:
Journal of medicinal chemistry. 63(10)
USP7 is a promising target for cancer therapy as its inhibition is expected to decrease function of oncogenes, increase tumor suppressor function, and enhance immune function. Using a structure-based drug design strategy, a new class of reversible US
Autor:
Yamini M, Ohol, Michael T, Sun, Gene, Cutler, Paul R, Leger, Dennis X, Hu, Berenger, Biannic, Payal, Rana, Cynthia, Cho, Scott, Jacobson, Steve T, Wong, Jerick, Sanchez, Niket, Shah, Deepa, Pookot, Betty, Abraham, Kyle, Young, Silpa, Suthram, Lisa A, Marshall, Delia, Bradford, Nathan, Kozon, Xinping, Han, Akinori, Okano, Jack, Maung, Christophe, Colas, Jacob, Schwarz, David, Wustrow, Dirk G, Brockstedt, Paul D, Kassner
Publikováno v:
Molecular cancer therapeutics. 19(10)
The deubiquitinase USP7 regulates the levels of multiple proteins with roles in cancer progression and immune response. Thus, USP7 inhibition may decrease oncogene function, increase tumor suppressor function, and sensitize tumors to DNA-damaging age
Autor:
Nick Shah, Berenger Biannic, Andrea Kim, Scott Jacobson, Dennis X. Hu, Deepika Kaveri, Jack Maung, Gene Cutler, Betty Abraham, Jerick Sanchez, David J. Wustrow, Steve Wong, Jacob Bradley Schwarz, Akinori Okano, Paul Leger, Xinping Han, Michael Sun, Oezcan Talay, Paul D. Kassner, Delia Bradford, Cynthia Cho, Kyle Young, Deepa Pookot, Yamini M. Ohol, Nathan Kozon, Lavanya Adusumilli, Dirk G. Brockstedt, Payal Rana, Christophe Colas
Publikováno v:
Cancer Research. 79:4441-4441
USP7 is a deubiquitinase that regulates the levels of multiple downstream targets with roles in cancer progression and immune response. Inhibitors of USP7 may thus decrease oncogene function, increase tumor suppressor function, enhance immune functio
Autor:
Subramanian Baskaran, Renae M. Crosby, John W. Seal, Zhiping Z. Xiong, Mi Xie, Hamilton D. Dickson, Roopa Rai, Pek Yoke Chong, Uli Schmitz, Jeffrey J. Pouliot, Derek J. Parks, J. Brad Shotwell, Amanda Mathis, Michael Thomson, Daniel J. Price, Jing Fang, Jack Maung, Katrina L. Creech, Dulce Garrido, Vincent W.-F. Tai, Andrew J. Peat
Publikováno v:
ACS Medicinal Chemistry Letters. 3:565-569
A series of imidazo[1,2-a]pyridines which directly bind to HCV Non-Structural Protein 4B (NS4B) is described. This series demonstrates potent in vitro inhibition of HCV replication (EC50 < 10 nM), direct binding to purified NS4B protein (IC50 < 20 nM