Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Jacinto Sarmentero"'
Autor:
Veronica Garcia-Carpizo, Sergio Ruiz-Llorente, Jacinto Sarmentero, Osvaldo Graña-Castro, David G. Pisano, Maria J. Barrero
Publikováno v:
Epigenetics & Chromatin, Vol 11, Iss 1, Pp 1-15 (2018)
Abstract Background The reported antitumor activity of the BET family bromodomain inhibitors has prompted the development of inhibitors against other bromodomains. However, the human genome encodes more than 60 different bromodomains and most of them
Externí odkaz:
https://doaj.org/article/1cadd9631f0b4b4fbc0049e7261406dc
Autor:
David Gallego-Ortega, Ana Ramirez de Molina, Maria Angeles Ramos, Fatima Valdes-Mora, Maria Gonzalez Barderas, Jacinto Sarmentero-Estrada, Juan Carlos Lacal
Publikováno v:
PLoS ONE, Vol 4, Iss 11, p e7819 (2009)
BACKGROUND:The Kennedy pathway generates phosphocoline and phosphoethanolamine through its two branches. Choline Kinase (ChoK) is the first enzyme of the Kennedy branch of synthesis of phosphocholine, the major component of the plasma membrane. ChoK
Externí odkaz:
https://doaj.org/article/07d9b7422e134c7c8ce5183626c74a0a
Autor:
Maria J. Barrero, Ana González-Corpas, Jacinto Sarmentero, Sergio Ruiz-Llorente, Veronica Garcia-Carpizo
GSEA enrichments for genes changing expression after JQ or CBP30 treatments. (a) Top reactome pathways significantly enriched in upregulated or downregulated genes. Black boxes indicate significant enrichment with P-value
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::069d75b21cae3edc6c027415a016a69b
https://doi.org/10.1158/1541-7786.22515885
https://doi.org/10.1158/1541-7786.22515885
Autor:
Maria J. Barrero, Ana González-Corpas, Jacinto Sarmentero, Sergio Ruiz-Llorente, Veronica Garcia-Carpizo
Oligonucleotides used in this study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e4b253855c1f2707bc954e787256a68
https://doi.org/10.1158/1541-7786.22515870
https://doi.org/10.1158/1541-7786.22515870
Autor:
Maria J. Barrero, Ana González-Corpas, Jacinto Sarmentero, Sergio Ruiz-Llorente, Veronica Garcia-Carpizo
Inhibitors that prevent the binding of bromodomains to acetylated histones hold therapeutic potential. However, the effects of targeting most of the 60 different bromodomains found in the human proteome remain unexplored. Here, we investigate the mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5fc2e1253a553a0211f866e1a754da3
https://doi.org/10.1158/1541-7786.c.6541209
https://doi.org/10.1158/1541-7786.c.6541209
Autor:
Anna La Salvia, Beatriz Gil-Calderón, Beatriz Rubio-Cuesta, Ángeles López-López, Rocio Garcia-Carbonero, Raúl Rincón, Carlos Carretero-Puche, Beatriz Soldevilla, Alberto Lens-Pardo, P. Espinosa-Olarte, Coral Barbas, Maria C Riesco-Martinez, Ángeles López-Gonzálvez, Jacinto Sarmentero
Publikováno v:
Cancers, Vol 13, Iss 2634, p 2634 (2021)
Cancers
Volume 13
Issue 11
Cancers
Volume 13
Issue 11
Simple Summary Metabolic flexibility is one of the key hallmarks of cancer and metabolites are the final products of this adaptation, reflecting the aberrant changes of tumors. However, the metabolic plasticity of each cancer type is still unknown, a
Autor:
Maria J. Barrero, Ana González-Corpas, Verónica García-Carpizo, Jacinto Sarmentero, Sergio Ruiz-Llorente
Publikováno v:
Molecular Cancer Research. 17:720-730
Inhibitors that prevent the binding of bromodomains to acetylated histones hold therapeutic potential. However, the effects of targeting most of the 60 different bromodomains found in the human proteome remain unexplored. Here, we investigate the mol
Autor:
Beatriz Rubio Cuesta, Beatriz Gil Calderón, Patricia LLamas Granda, Jacinto Sarmentero, Carlos Carretero Puche, María del Carmen Riesco, Rocío García Carbonero, Beatriz Soldevilla
Publikováno v:
Cancer Research. 82:355-355
Oncogenic mutations in B-type Raf Kinase (BRAF) (particularly V600E) are present in 7-10% of metastatic colorectal cancer (mCRC), conferring resistance to conventional therapies and a poor prognosis. Src Family Kinases (SFKs) play a relevant role in
Autor:
Maria J. Barrero, Osvaldo Graña-Castro, Sergio Ruiz-Llorente, Jacinto Sarmentero, Verónica García-Carpizo, David G. Pisano
Publikováno v:
Epigenetics & Chromatin, Vol 11, Iss 1, Pp 1-15 (2018)
Repisalud
Instituto de Salud Carlos III (ISCIII)
Repisalud
Instituto de Salud Carlos III (ISCIII)
BACKGROUND: The reported antitumor activity of the BET family bromodomain inhibitors has prompted the development of inhibitors against other bromodomains. However, the human genome encodes more than 60 different bromodomains and most of them remain
The discovery of the antiproliferative effects of BRD4 bromodomain inhibitors prompted us to investigate additional bromodomains that might be involved in supporting cellular proliferation. TAF1 is a general transcription factor with two bromodomains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26dd493bb9bd57d965451f7903a8155a
https://doi.org/10.1101/394254
https://doi.org/10.1101/394254