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Discovery of potent and selective PPARα/δ dual antagonists and initial biological studies.

Autor: Jacintho JD; Inception Sciences, Suite 100, 5871 Oberlin Drive, San Diego, CA 92121, USA. Electronic address: jjacintho@inceptionsci.com., Baccei CS; Inception Sciences, Suite 100, 5871 Oberlin Drive, San Diego, CA 92121, USA., Bravo Y; Inception Sciences, Suite 100, 5871 Oberlin Drive, San Diego, CA 92121, USA., Broadhead A; Inception Sciences, Suite 100, 5871 Oberlin Drive, San Diego, CA 92121, USA., Chen A; Inception Sciences, Suite 100, 5871 Oberlin Drive, San Diego, CA 92121, USA., Correa L; Inception Sciences, Suite 100, 5871 Oberlin Drive, San Diego, CA 92121, USA., Fischer K; Inception Sciences, Suite 100, 5871 Oberlin Drive, San Diego, CA 92121, USA., Laffitte B; Inception Sciences, Suite 100, 5871 Oberlin Drive, San Diego, CA 92121, USA., Lee C; Inception Sciences, Suite 100, 5871 Oberlin Drive, San Diego, CA 92121, USA., Lorrain DS; Inception Sciences, Suite 100, 5871 Oberlin Drive, San Diego, CA 92121, USA., Messmer D; Inception Sciences, Suite 100, 5871 Oberlin Drive, San Diego, CA 92121, USA., Prasit P; Inception Sciences, Suite 100, 5871 Oberlin Drive, San Diego, CA 92121, USA., Stebbins KJ; Inception Sciences, Suite 100, 5871 Oberlin Drive, San Diego, CA 92121, USA., Stock NS; Inception Sciences, Suite 100, 5871 Oberlin Drive, San Diego, CA 92121, USA.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2019 Feb 01; Vol. 29 (3), pp. 503-508. Date of Electronic Publication: 2018 Dec 21.

Discovery of a series of phosphonic acid-containing thiazoles and orally bioavailable diamide prodrugs that lower glucose in diabetic animals through inhibition of fructose-1,6-bisphosphatase.

Autor: Dang Q; Department of Medicinal Chemistry, Metabasis Therapeutics, Inc., La Jolla, California 92037, United States. qun_dang@merck.com, Liu Y, Cashion DK, Kasibhatla SR, Jiang T, Taplin F, Jacintho JD, Li H, Sun Z, Fan Y, DaRe J, Tian F, Li W, Gibson T, Lemus R, van Poelje PD, Potter SC, Erion MD

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2011 Jan 13; Vol. 54 (1), pp. 153-65. Date of Electronic Publication: 2010 Dec 02.

Systemic lupus erythematosus and other autoimmune diseases from endogenous and exogenous agents: unifying theme of oxidative stress.

Autor: Kovacic P; Department of Chemistry, San Diego State University, San Diego, California 92182 USA. pkovacic@sundown.sdsu.edu, Jacintho JD

Publikováno v: Mini reviews in medicinal chemistry [Mini Rev Med Chem] 2003 Sep; Vol. 3 (6), pp. 568-75.