Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jacinth Wing-Sum Cheu"'
Autor:
Jacinth Wing-Sum Cheu, Derek Lee, Qidong Li, Chi Ching Goh, Macus Hao-Ran Bao, Vincent Wai-Hin Yuen, Misty Shuo Zhang, Chunxue Yang, Cerise Yuen-Ki Chan, Aki Pui-Wah Tse, Grace Fu-Wan Sit, Cindy Xinqi Liu, Irene Oi-Lin Ng, Chun-Ming Wong, Carmen Chak-Lui Wong
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 16, Iss 1, Pp 133-159 (2023)
Background & Aims: Hepatocellular carcinoma (HCC) is a highly aggressive malignancy with dreadful clinical outcome. Tyrosine kinase inhibitors and immune checkpoint inhibitors are the only United States Food and Drug Administration-approved therapeut
Externí odkaz:
https://doaj.org/article/23e349922f66486cae9f9e28d7a79df0
Autor:
Misty Shuo Zhang, Jane Di Cui, Derek Lee, Vincent Wai-Hin Yuen, David Kung-Chun Chiu, Chi Ching Goh, Jacinth Wing-Sum Cheu, Aki Pui-Wah Tse, Macus Hao-Ran Bao, Bowie Po Yee Wong, Carrie Yiling Chen, Chun-Ming Wong, Irene Oi-Lin Ng, Carmen Chak-Lui Wong
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Cancer cells rely on macropinocytosis to scavenge extracellular proteins for growth. Here the authors show that macropinocytosis supports the survival of hypoxic hepatocellular carcinoma cells and this is dependent on HIF-1, which in turns activates
Externí odkaz:
https://doaj.org/article/8f5cd23985f9487db506e2ab8cfaa555
Autor:
Noreen Nog‐Qin Chui, Jacinth Wing‐Sum Cheu, Vincent Wai‐Hin Yuen, David Kung‐Chun Chiu, Chi‐Ching Goh, Derek Lee, Misty Shuo Zhang, Irene Oi‐Lin Ng, Carmen Chak‐Lui Wong
Publikováno v:
Hepatology Communications, Vol 6, Iss 1, Pp 178-193 (2022)
Liver cancers consist primarily of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). Immune checkpoint inhibitors have emerged as promising therapeutic agents against liver cancers. Programmed cell death protein 1 (PD‐1) is
Externí odkaz:
https://doaj.org/article/1cb8ee00c2544afaa44cf0d59d133628
Autor:
Daniel Wai-Hung Ho, Yu-Man Tsui, Lo-Kong Chan, Karen Man-Fong Sze, Xin Zhang, Jacinth Wing-Sum Cheu, Yung-Tuen Chiu, Joyce Man-Fong Lee, Albert Chi-Yan Chan, Elaine Tin-Yan Cheung, Derek Tsz-Wai Yau, Nam-Hung Chia, Irene Lai-Oi Lo, Pak-Chung Sham, Tan-To Cheung, Carmen Chak-Lui Wong, Irene Oi-Lin Ng
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Different cells of the tumour microenvironment in HBV-associated human hepatocellular carcinoma (HCC) interact to promote tumour immunity. Here the authors use single cell RNA sequencing to identify TIGIT-NECTIN2 as a pathway by which tumour-associat
Externí odkaz:
https://doaj.org/article/f985f3f45e114476aff8ed39645b53e3
Autor:
Cerise Yuen‐Ki Chan, Vincent Wai‐Hin Yuen, David Kung‐Chun Chiu, Chi‐Ching Goh, Kelsie L. Thu, David W. Cescon, Isabel Soria‐Bretones, Cheuk‐Ting Law, Jacinth Wing‐Sum Cheu, Derek Lee, Aki Pui‐Wah Tse, Kel Vin Tan, Misty Shuo Zhang, Bowie Po‐Yee Wong, Chun‐Ming Wong, Pek‐Lan Khong, Irene Oi‐Lin Ng, Mark R. Bray, Tak Wah Mak, Thomas Chung‐Cheung Yau, Carmen Chak‐Lui Wong
Publikováno v:
Hepatology. 77:729-744
Prognosis of HCC remains poor due to lack of effective therapies. Immune checkpoint inhibitors (ICIs) have delayed response and are only effective in a subset of patients. Treatments that could effectively shrink the tumors within a short period of t
Autor:
Vincent Wai-Hin Yuen, David Kung-Chun Chiu, Cheuk-Ting Law, Jacinth Wing-Sum Cheu, Cerise Yuen-Ki Chan, Bowie Po-Yee Wong, Chi-Ching Goh, Misty Shuo Zhang, Helen Do-Gai Xue, Aki Pui-Wah Tse, Yan Zhang, Henry Yee-Hin Lau, Derek Lee, Rex K.H. Au-Yeung, Chun-Ming Wong, Carmen Chak-Lui Wong
Publikováno v:
Journal of Hepatology. 78:376-389
Tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs) are the only two classes of FDA-approved drugs for individuals with advanced hepatocellular carcinoma (HCC). While TKIs confer only modest survival benefits, ICIs have been ass
Autor:
Jacinth Wing-Sum Cheu, David Kung-Chun Chiu, Kenneth Kin-Leung Kwan, Chunxue Yang, Vincent Wai-Hin Yuen, Chi Ching Goh, Noreen Nog-Qin Chui, Wei Shen, Cheuk-Ting Law, Qidong Li, Misty Shuo Zhang, Macus Hao-Ran Bao, Bowie Po-Yee Wong, Cerise Yuen-Ki Chan, Cindy Xinqi Liu, Grace Fu-Wan Sit, Zher Yee Ooi, Haijing Deng, Aki Pui-Wah Tse, Irene Oi-Lin Ng, Carmen Chak-Lui Wong
Publikováno v:
Science Advances. 9
Hypoxia-induced adenosine creates an immunosuppressive tumor microenvironment (TME) and dampens the efficacy of immune checkpoint inhibitors (ICIs). We found that hypoxia-inducible factor 1 (HIF-1) orchestrates adenosine efflux through two steps in h
Autor:
Cerise Yuen-Ki Chan, David Kung-Chun Chiu, Vincent Wai-Hin Yuen, Cheuk-Ting Law, Bowie Po-Yee Wong, Kelsie Lynn Thu, David Ward Cescon, Isabel Soria-Bretones, Jacinth Wing-Sum Cheu, Derek Lee, Aki Pui-Wah Tse, Misty Shuo Zhang, Kel Vin Tan, Irene Oi-Lin Ng, Pek-Lan Khong, Thomas Chung-Cheung Yau, Mark Robert Bray, Tak Wah Mak, Carmen Chak-Lui Wong
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Deregulation of cell cycle is a typical feature of cancer cells. Normal cells rely on the strictly coordinated spindle assembly checkpoint (SAC) to maintain the genome integrity and survive. However, cancer cells could bypass this checkpoint mechanis
Autor:
Derek Lee, Misty Shuo Zhang, David Kung-Chun Chiu, Vincent Wai-Hin Yuen, Carmen Chak-Lui Wong, Noreen Nog-Qin Chui, Jacinth Wing-Sum Cheu, Chi-Ching Goh, Irene Oi-Lin Ng
Publikováno v:
Hepatology Communications
Hepatology Communications, Vol 6, Iss 1, Pp 178-193 (2022)
Hepatology Communications, Vol 6, Iss 1, Pp 178-193 (2022)
Liver cancers consist primarily of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). Immune checkpoint inhibitors have emerged as promising therapeutic agents against liver cancers. Programmed cell death protein 1 (PD‐1) is
Publikováno v:
Cancer Research. 83:3675-3675
Ferroptosis is a novel immunogenic and regulated cell death caused by iron-dependent lipid peroxidation. Glutathione peroxidase 4(GPX4)/glutathione and ferroptosis suppressor protein 1(FSP1)/Coenzyme Q10(CoQ10) are two major anti-ferroptosis systems