Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Jacinth Naidoo"'
Autor:
Terry C. Yin, Jeremiah K. Britt, Héctor De Jesús-Cortés, Yuan Lu, Rachel M. Genova, Michael Z. Khan, Jaymie R. Voorhees, Jianqiang Shao, Aaron C. Katzman, Paula J. Huntington, Cassie Wassink, Latisha McDaniel, Elizabeth A. Newell, Laura M. Dutca, Jacinth Naidoo, Huxing Cui, Alexander G. Bassuk, Matthew M. Harper, Steven L. McKnight, Joseph M. Ready, Andrew A. Pieper
Publikováno v:
Cell Reports, Vol 8, Iss 6, Pp 1731-1740 (2014)
The P7C3 class of neuroprotective aminopropyl carbazoles has been shown to block neuronal cell death in models of neurodegeneration. We now show that P7C3 molecules additionally preserve axonal integrity after injury, before neuronal cell death occur
Externí odkaz:
https://doaj.org/article/eaf07f99280f4695b3055e2a7c8aa34d
Autor:
Jerry W. Shay, Jue Liang, Prasanna Bhat, Joseph M. Ready, Beatriz M. A. Fontoura, Matthew Esparza, Bruce A. Posner, Jacinth Naidoo, Busola R. Alabi, Kris M. White, Adolfo García-Sastre, Briana L. McGovern, Michael A. P. Williams, Hanspeter Niederstrasser
Publikováno v:
J Med Chem
Influenza viruses cause approximately half a million deaths every year worldwide. Vaccines are available but partially effective, and the number of antiviral medications is limited. Thus, it is crucial to develop therapeutic strategies to counteract
Autor:
Rui Chen, Jipeng Wang, Irina Gradinaru, Hieu S. Vu, Sophie Geboers, Jacinth Naidoo, Joseph M. Ready, Noelle S. Williams, Ralph J. DeBerardinis, Elliott M. Ross, James J. Collins
Publikováno v:
Cell. 185(9)
Schistosomes cause morbidity and death throughout the developing world due to the massive numbers of eggs female worms deposit into the blood of their host. Studies dating back to the 1920s show that female schistosomes rely on constant physical cont
Autor:
Sophie Geboers, Hong Chen, Joseph M. Ready, Prema L. Mallipeddi, Bruce A. Posner, Giomar Rivera-Cancel, Francisco Ortiz, Stephen S. Gonzales, Panayotis C. Theodoropoulos, Deepak Nijhawan, Sukesh Voruganti, Noelle S. Williams, Jacinth Naidoo
Publikováno v:
Journal of medicinal chemistry. 63(17)
A series of N-acyl benzothiazoles shows selective and potent cytotoxicity against cancer cell lines expressing cytochrome P450 4F11. A prodrug form is metabolized by cancer cells into an active inhibitor of stearoyl-CoA desaturase (SCD). Substantial
Autor:
Alexander Bukreyev, Manu Anantpadma, Colette Pietzsch, Megan R. Edwards, Caroline G. Williams, Sudip Khadka, Sampriti De, Joseph M. Ready, Jacinth Naidoo, Robert A. Davey, Priya Luthra, Christopher F. Basler
Publikováno v:
Antiviral Research. 158:288-302
Specific host pathways that may be targeted therapeutically to inhibit the replication of Ebola virus (EBOV) and other emerging viruses remain incompletely defined. A screen of 200,000 compounds for inhibition of an EBOV minigenome (MG) assay that me
Autor:
Bart P. H. J. Thomma, Thomas Lahaye, Jacinth Naidoo, Edda von Roepenack-Lahaye, Caitilyn Allen, Tiffany M. Lowe-Power, Raka M. Mitra, Connor G. Hendrich, Patrick H. Masson, Anthony J. Michael, Dousheng Wu, David Cook, Amy L. Jancewicz, Beth L. Dalsing, Bin Li, Patrizia Ricca
Publikováno v:
Environmental Microbiology, 20(4), 1330-1349
Environmental Microbiology 20 (2018) 4
Environmental microbiology, vol 20, iss 4
Environmental Microbiology 20 (2018) 4
Environmental microbiology, vol 20, iss 4
Ralstonia solanacearum thrives in plant xylem vessels and causes bacterial wilt disease despite the low nutrient content of xylem sap. We found that R. solanacearum manipulates its host to increase nutrients in tomato xylem sap, enabling it to grow b
Autor:
Jacinth Naidoo, Yongyou Zhang, Jennifer M. Doran, Joseph M. Ready, Sanford D. Markowitz, Chang-Guang Wang, Sukesh Voruganti, Noelle S. Williams, Monika I. Antczak
Publikováno v:
Journal of Medicinal Chemistry. 60:3979-4001
The enzyme 15-prostaglandin dehydrogenase (15-PGDH) catalyzes the first step in the degradation of prostaglandins including PGE2. It is a negative regulator of tissue repair and regeneration in multiple organs. Accordingly, inhibitors of 15-PGDH are
Autor:
John B. MacMillan, Bin Li, Stephen S. Gonzales, Shin Kurihara, Caitilyn Allen, Jacinth Naidoo, Tiffany M. Lowe-Power, Anthony J. Michael
Publikováno v:
ACS Chemical Biology. 11:2782-2789
The small polyamine putrescine (1,4-diaminobutane) is ubiquitously and abundantly found in all three domains of life. It is a precursor, through N-aminopropylation or N-aminobutylation, for biosynthesis of the longer polyamines spermidine, sym-homosp
Autor:
Tessa Gordon, Noelle S. Williams, Stephen W.P. Kemp, Matthew D. Wood, Joseph M. Ready, Thomas J. Mangano, Michael P. Willand, K. N. Stanoulis, Andrew A. Pieper, Simon Beggs, Mark Szynkaruk, Jacinth Naidoo, Lorraine Morlock, Michael W. Salter, Edward H. Liu, G. H. Borschel
Publikováno v:
Neuroscience. 284:202-216
Nerve injuries cause pain, paralysis and numbness that can lead to major disability, and newborns often sustain nerve injuries during delivery that result in lifelong impairment. Without a pharmacologic agent to enhance functional recovery from these
Autor:
Laura, Hobley, Bin, Li, Jennifer L, Wood, Sok Ho, Kim, Jacinth, Naidoo, Ana Sofia, Ferreira, Maxim, Khomutov, Alexey, Khomutov, Nicola R, Stanley-Wall, Anthony J, Michael
Publikováno v:
The Journal of Biological Chemistry
Ubiquitous polyamine spermidine is not required for normal planktonic growth of Bacillus subtilis but is essential for robust biofilm formation. However, the structural features of spermidine required for B. subtilis biofilm formation are unknown and