Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Jacinta L. Simmons"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
The acquisition of resistance to anoikis, the cell death induced by loss of adhesion to the extracellular matrix, is an absolute requirement for the survival of disseminating and circulating tumour cells (CTCs), and for the seeding of metastatic lesi
Externí odkaz:
https://doaj.org/article/941fbfc426b34ddfa01f6bbf58601541
Autor:
Jason K. Cullen, Glen M. Boyle, Pei-Yi Yap, Stefan Elmlinger, Jacinta L. Simmons, Natasa Broit, Jenny Johns, Blake Ferguson, Lidia A. Maslovskaya, Andrei I. Savchenko, Paul Malek Mirzayans, Achim Porzelle, Paul V. Bernhardt, Victoria A. Gordon, Paul W. Reddell, Alberto Pagani, Giovanni Appendino, Peter G. Parsons, Craig M. Williams
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract The long-standing perception of Protein Kinase C (PKC) as a family of oncoproteins has increasingly been challenged by evidence that some PKC isoforms may act as tumor suppressors. To explore the hypothesis that activation, rather than inhib
Externí odkaz:
https://doaj.org/article/48af2e8d91fb499798d2ad925238a5a8
Autor:
Karina D. Hamilton, Daniel Czajkowski, Nicolas J. Kong, Trong D. Tran, Kirk R. Gustafson, Gary Pauly, Glen M. Boyle, Jacinta L. Simmons, Robert Steadman, Ryan Moseley, Peter R. Brooks, Steven M. Ogbourne, Fraser D. Russell
Publikováno v:
Antioxidants, Vol 11, Iss 8, p 1604 (2022)
Bioactivity-guided fractionation was used to isolate two compounds, tomentosenol A (1) and torellianone A (2), from a cerumen extract from Tetragonula carbonaria. The anti-fibrotic activity of these compounds was examined using human cultured neonata
Externí odkaz:
https://doaj.org/article/58110c04aace4746b4251c0bac3cea21
Autor:
Mitchell E. Fane, Yash Chhabra, David E.J. Hollingsworth, Jacinta L. Simmons, Loredana Spoerri, Tae Gyu Oh, Jagat Chauhan, Toby Chin, Lachlan Harris, Tracey J. Harvey, George E.O. Muscat, Colin R. Goding, Richard A Sturm, Nikolas K. Haass, Glen M. Boyle, Michael Piper, Aaron G. Smith
Publikováno v:
EBioMedicine, Vol 16, Iss C, Pp 63-75 (2017)
While invasion and metastasis of tumour cells are the principle factor responsible for cancer related deaths, the mechanisms governing the process remain poorly defined. Moreover, phenotypic divergence of sub-populations of tumour cells is known to u
Externí odkaz:
https://doaj.org/article/1d9c7e7e95224d40a32f42bb4b0ce6d1
Autor:
Craig M. Williams, Natasa Broit, Alberto Pagani, Giovanni Appendino, Lidia A. Maslovskaya, Jenny P. Johns, Jacinta L. Simmons, Glen M. Boyle, Stefan Elmlinger, Blake Ferguson, Peter G. Parsons, Achim Porzelle, Paul Reddell, Paul V. Bernhardt, Pei Yi Yap, Jason K. Cullen, Andrei I. Savchenko, Victoria A. Gordon, Paul Malek Mirzayans
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports
Scientific Reports
The long-standing perception of Protein Kinase C (PKC) as a family of oncoproteins has increasingly been challenged by evidence that some PKC isoforms may act as tumor suppressors. To explore the hypothesis that activation, rather than inhibition, of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::323962573ce99a67035d5b7c004178c1
https://doaj.org/article/48af2e8d91fb499798d2ad925238a5a8
https://doaj.org/article/48af2e8d91fb499798d2ad925238a5a8
Autor:
Glen M. Boyle, Natasa Broit, Carly J. Pierce, Jacinta L. Simmons, Deshapriya S. Karunarathne, Mei Fong Ng
Publikováno v:
Oncogenesis, Vol 9, Iss 7, Pp 1-12 (2020)
Oncogenesis
Oncogenesis
Melanoma tumors are highly heterogeneous, comprising of many cell populations that vary in their potential for growth and invasion. Differential transcription factor expression contributes to these phenotypic traits. BRN2, a member of the POU domain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27fe00ce6443af301602ac2cac54a4bd
http://link.springer.com/article/10.1038/s41389-020-00247-1
http://link.springer.com/article/10.1038/s41389-020-00247-1
Publikováno v:
Advanced Drug Delivery Reviews. 153:54-64
Skin cancer is a broad term used to describe a number of different malignant indications of the skin. Skin cancers mostly comprise of the keratinocyte cancers [Basal Cell Carcinoma (BCC) and cutaneous Squamous Cell Carcinoma (SCC)], and melanoma. Sur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96544253e464b495febff91924c15c3e
https://doi.org/10.1016/j.addr.2019.11.002
https://doi.org/10.1016/j.addr.2019.11.002
Publikováno v:
Cancers. 14:3030
There is growing evidence that tumour heterogeneity has an imperative role in cancer development, evolution and resistance to therapy. Continuing advancements in biomedical research enable tumour heterogeneity to be observed and studied more critical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68c61c1c7d10ab7ce21620b59bca8c68
https://doi.org/10.3390/cancers14123030
https://doi.org/10.3390/cancers14123030
Autor:
Mitchell E. Fane, Yash Chhabra, Loredana Spoerri, Jacinta L. Simmons, Raquelle Ludwig, Elise Bonvin, Colin R. Goding, Richard A. Sturm, Glen M. Boyle, Nikolas K. Haass, Michael Piper, Aaron G. Smith
Phenotypic plasticity drives cancer progression, impacts treatment response, and is a major driver of therapeutic resistance. In melanoma, a regulatory axis between the MITF and BRN2 transcription factors has been reported to promote tumor heterogene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3042e17f105711e34d1fd1a7ecb80880
https://doi.org/10.1016/j.jid.2020.12.039
https://doi.org/10.1016/j.jid.2020.12.039
Publikováno v:
Anoikis ISBN: 9783030738549
Anoikis is the cell death induced by inappropriate, or lack of, cell adhesion. Many of the previous investigations have focused on the mechanisms leading to anoikis resistance of epithelial-derived tumor cells, and on determining pathways leading to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8f70cd35530aa7a117b283f771964d4
https://doi.org/10.1007/978-3-030-73856-3_7
https://doi.org/10.1007/978-3-030-73856-3_7