Radiolabelling of Polyclonally Expanded Human Regulatory T Cells (Treg) with 89Zr-oxine for Medium-Term In Vivo Cell Tracking

Autor: Jacinta Jacob, Alessia Volpe, Qi Peng, Robert I. Lechler, Lesley A. Smyth, Giovanna Lombardi, Gilbert O. Fruhwirth

Publikováno v: Molecules, Vol 28, Iss 3, p 1482 (2023)

Regulatory T cells (Tregs) are a promising candidate cell therapy to treat autoimmune diseases and aid the longevity of transplanted solid organs. Despite increasing numbers of clinical trials using human Treg therapy, important questions pertaining

Externí odkaz: https://doaj.org/article/c2ce8a9f7b0347a791e20018dcb780c4

Spatiotemporal in vivo tracking of polyclonal human regulatory T cells (Tregs) reveals a role for innate immune cells in Treg transplant recruitment

Autor: Cristiano Scottà, Federica M. Marelli-Berg, Jacinta Jacob, Alessia Volpe, Suchita Nadkarni, Giovanna Lombardi, Sim L. Tung, Gilbert O. Fruhwirth, Yasmin R. Mohseni, Rosalind F. Hannen, Qi Peng, Lesley A. Smyth, Robert I. Lechler

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 20, Iss, Pp 324-336 (2021)

Regulatory T cells (Tregs) are emerging as a new cell-based therapy in solid organ transplantation. Adoptive transfer of Tregs has been shown preclinically to protect from graft rejection, and the safety of Treg therapy has been demonstrated in clini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59e750952728c7b60c6ba45a1d33637a
https://doi.org/10.1016/j.omtm.2020.12.003

Protease Activated Receptor 4 as a Novel Modulator of Regulatory T Cell Function

Autor: Jacinta Jacob, Kulachelvy Ratnasothy, Dominic A. Boardman, Robert I. Lechler, Qi Peng, Anthony Dorling, Sim L. Tung, Giovanna Lombardi, Daniel McCluskey, Lesley A. Smyth

Publikováno v: Frontiers in Immunology, Vol 10 (2019)
Peng, Q, Ratnasothy, K, Boardman, D A, Jacob, J, Tung, S L, Mccluskey, D, Smyth, L A, Lechler, R I, Dorling, A & Lombardi, G 2019, ' Protease Activated Receptor 4 as a Novel Modulator of Regulatory T Cell Function ', Frontiers in Immunology, vol. 10, no. JUN, 1311, pp. 1-14 . https://doi.org/10.3389/fimmu.2019.01311
Frontiers in Immunology

Regulatory T cells (Tregs) are a subpopulation of T cells that maintain immunological tolerance. In inflammatory responses the function of Tregs is tightly controlled by several factors including signaling through innate receptors such as Toll like r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b0c93e777fb3c90accd7841d9a3cc3b