Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Jacinta I. Kalisch-Smith"'
Autor:
Jacinta I. Kalisch-Smith, Nikita Ved, Dorota Szumska, Jacob Munro, Michael Troup, Shelley E. Harris, Helena Rodriguez-Caro, Aimée Jacquemot, Jack J. Miller, Eleanor M. Stuart, Magda Wolna, Emily Hardman, Fabrice Prin, Eva Lana-Elola, Rifdat Aoidi, Elizabeth M. C. Fisher, Victor L. J. Tybulewicz, Timothy J. Mohun, Samira Lakhal-Littleton, Sarah De Val, Eleni Giannoulatou, Duncan B. Sparrow
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
From mouse experiments, the authors link iron deficiency in mothers with cardiovascular defects and increased retinoic acid signalling in their offspring, and giving iron early in pregnancy can prevent most defects.
Externí odkaz:
https://doaj.org/article/151683b89d484445a2fc425e4f26bd68
Autor:
Jacinta I. Kalisch-Smith, Emily C. Morris, Mary A. A. Strevens, Andia N. Redpath, Kostantinos Klaourakis, Dorota Szumska, Jennifer E. Outhwaite, Xin Sun, Joaquim Miguel Vieira, Nicola Smart, Sarah De Val, Paul R. Riley, Duncan B. Sparrow
Publikováno v:
Frontiers in Genetics, Vol 12 (2022)
The placental vasculature provides the developing embryo with a circulation to deliver nutrients and dispose of waste products. However, in the mouse, the vascular components of the chorio-allantoic placenta have been largely unexplored due to a lack
Externí odkaz:
https://doaj.org/article/65a5a2d0d0f643d38839c84a26d650f5
Autor:
Sophie Broadway-Stringer, He Jiang, Kirsty Wadmore, Charlotte Hooper, Gillian Douglas, Violetta Steeples, Amar J. Azad, Evie Singer, Jasmeet S. Reyat, Frantisek Galatik, Elisabeth Ehler, Pauline Bennett, Jacinta I. Kalisch-Smith, Duncan B. Sparrow, Benjamin Davies, Kristina Djinovic-Carugo, Mathias Gautel, Hugh Watkins, Katja Gehmlich
Publikováno v:
Cells, Vol 12, Iss 5, p 721 (2023)
Pathogenic variants in ACTN2, coding for alpha-actinin 2, are known to be rare causes of Hypertrophic Cardiomyopathy. However, little is known about the underlying disease mechanisms. Adult heterozygous mice carrying the Actn2 p.Met228Thr variant wer
Externí odkaz:
https://doaj.org/article/0ba42ffd89aa445d9501041c0b0f406d
Autor:
Emily S. Dorey, Sarah L. Walton, Jacinta I. Kalisch‐Smith, Tamara M. Paravicini, Emelie M. Gardebjer, Kristy A. Weir, Reetu R. Singh, Helle Bielefeldt‐Ohmann, Stephen T. Anderson, Mary E. Wlodek, Karen M. Moritz
Publikováno v:
Physiological Reports, Vol 7, Iss 21, Pp n/a-n/a (2019)
Abstract Maternal alcohol consumption can impair renal development and program kidney dysfunction in offspring. Given that most women who drink alcohol cease consumption upon pregnancy recognition, we aimed to investigate the effect of alcohol around
Externí odkaz:
https://doaj.org/article/298effb342bb44d39fefa50abeadfcca
Autor:
Emelie M. Gardebjer, Arree M Fielding, Jacinta I. Kalisch-Smith, Isabella Andersen, Mitchell A. Sullivan, Karen M. Moritz, Daniel J Browne, Nykola L. Kent, Ellen N Tejo, Sarah E. Steane, Lisa K. Akison
Publikováno v:
Alcoholism, clinical and experimental researchREFERENCES. 45(10)
Maternal choline supplementation in rats can ameliorate specific neurological and behavioral abnormalities caused by alcohol exposure during pregnancy. We aimed to test whether choline supplementation could ameliorate fetal growth restriction and mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12e1fa4a0f207d5d2466d3ce6a1c4ec4
https://pubmed.ncbi.nlm.nih.gov/34342027
https://pubmed.ncbi.nlm.nih.gov/34342027
Autor:
Dorota Szumska, Jack J. Miller, Magda Wolna, Aimée Jacquemot, Victor L. J. Tybulewicz, Michael Troup, Fabrice Prin, Eleni Giannoulatou, Helena Rodriguez-Caro, Eleanor M. Stuart, Emily Hardman, Jacob E Munro, Elizabeth M. C. Fisher, Samira Lakhal-Littleton, Nikita Ved, Sarah De Val, Eva Lana-Elola, Rifdat Aoidi, Jacinta I. Kalisch-Smith, Shelley Harris, Duncan B. Sparrow, Timothy J. Mohun
Publikováno v:
Kalisch-Smith, J I, Ved, N, Szumska, D, Munro, J, Troup, M, Harris, S E, Rodriguez-Caro, H, Jacquemot, A, Miller, J J, Stuart, E M, Wolna, M, Hardman, E, Prin, F, Lana-Elola, E, Aoidi, R, Fisher, E M C, Tybulewicz, V L J, Mohun, T J, Lakhal-Littleton, S, De Val, S, Giannoulatou, E & Sparrow, D B 2021, ' Maternal iron deficiency perturbs embryonic cardiovascular development in mice ', Nature Communications, vol. 12, no. 1, 3447 . https://doi.org/10.1038/s41467-021-23660-5
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Congenital heart disease (CHD) is the most common class of human birth defects, with a prevalence of 0.9% of births. However, two-thirds of cases have an unknown cause, and many of these are thought to be caused by in utero exposure to environmental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd67229f327bbe8fade19b292cc5b098
https://www.repository.cam.ac.uk/handle/1810/323588
https://www.repository.cam.ac.uk/handle/1810/323588
Autor:
Nicola Smart, Dorota Szumska, Jacinta I. Kalisch-Smith, Joaquim M. Vieira, Morris Ec, Andia N. Redpath, J.E. Outhwaite, De Val S, Konstantinos Klaourakis, Paul R. Riley, Strevens Ma, Duncan B. Sparrow
Placental vascular gene networks in mammals have been largely unexplored due to a lack of well validated molecular markers to identify them. This is required to study how they form in development, and how they are impacted by embryonic or maternal de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39c02258c8fd11696fc8608cc956df3d
https://doi.org/10.1101/2021.05.06.442902
https://doi.org/10.1101/2021.05.06.442902
Autor:
Julia Beglov, Henrik Isackson, Elisabeth Ehler, Jacinta I. Kalisch-Smith, Violetta Steeples, Duncan B. Sparrow, Katja Gehmlich, Pauline M. Bennett, Norbert Huebner, Charlotte Hooper, Raphael Heilig, Giannino Patone, Benjamin Davies, Hugh Watkins, Amar J. Azad, He Jiang, Mehroz Ehsan, Lisa Leinhos, Jillian N. Simon, Roman Fischer, Matthew Kelly
Publikováno v:
Basic Research in Cardiology
Titin truncating variants are a well-established cause of cardiomyopathy; however, the role of titin missense variants is less well understood. Here we describe the generation of a mouse model to investigate the underlying disease mechanism of a prev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd9bae3d34d47f484f0c6895019203df
https://doi.org/10.1007/s00395-021-00853-z
https://doi.org/10.1007/s00395-021-00853-z
Autor:
Samira Lakhal-Littleton, Timothy J. Mohun, Fabrice Prin, Jacinta I. Kalisch-Smith, Michael Troup, Eva Lana-Elola, Eleni Giannoulatou, Jacob E Munro, Jack J. Miller, Duncan B. Sparrow, Magda Wolna, Emily Hardman, Rifdat Aoidi, Nikita Ved, Dorota Szumska, Aimée Jacquemot, Fisher Emc., Tybulewicz Vlj, Stuart Em, Shelley Harris
Congenital heart disease (CHD) is the most common type of birth defect, with a global prevalence of 0.9% of live births1. Most research in the last 30 years has focused on finding genetic causes of CHD. However, despite the association of over 100 ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cc71588a3888aea2513dac14db3d54e
https://doi.org/10.1101/2020.08.03.230615
https://doi.org/10.1101/2020.08.03.230615
Publikováno v:
Biology of Sex Differences, Vol 8, Iss 1, Pp 1-13 (2017)
Biology of Sex Differences
Biology of Sex Differences
Background A male fetus is suggested to be more susceptible to in utero and birth complications. This may be due in part to altered morphology or function of the XY placenta. We hypothesised that sexual dimorphism begins at the blastocyst stage with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23f56c52c682379b55eabf3e58519a1e
http://link.springer.com/article/10.1186/s13293-017-0138-6
http://link.springer.com/article/10.1186/s13293-017-0138-6