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Akademický článek

Cell Death Triggered by the Autophagy Inhibitory Drug 3-Methyladenine in Growing Conditions Proceeds With DNA Damage

Autor: Javier Chicote, Víctor J. Yuste, Jacint Boix, Judit Ribas

Publikováno v: Frontiers in Pharmacology, Vol 11 (2020)

Macroautophagy (hereafter autophagy) is a multistep intracellular catabolic process with pleiotropic implications in cell fate. Attending to its activation, autophagy can be classified into inducible or constitutive. Constitutive, or basal autophagy,

Externí odkaz: https://doaj.org/article/75bbb9e4fa984eb8aed5114aad019985

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Cell death induced by 2-phenylethynesulfonamide uncovers a pro-survival function of BAX

Autor: Judit Ribas, Marta Ripamonti, Josep Amigó, Jacint Boix, Paolo Mattiolo, Ares Barbero-Farran

Publikováno v: Repositorio Abierto de la UdL
Universitad de Lleida
Recercat. Dipósit de la Recerca de Catalunya
instname

PES (2-phenylethynesulfonamide) was initially identified as an inhibitor of p53 translocation to mitochondria and named Pifithrin-µ. Further studies showed that PES selectively killed tumour cells and was thus a promising anticancer agent. PES-induc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6709b9b2911de3969a89f4e805dc695
https://doi.org/10.1016/j.canlet.2014.07.037

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2-Phenylethynesulfonamide (PES) uncovers a necrotic process regulated by oxidative stress and p53

Autor: Jacint Boix, Victor J. Yuste, Ares Barbero-Farran, Paolo Mattiolo, Judit Ribas

Publikováno v: Repositorio Abierto de la UdL
Universitad de Lleida
Recercat. Dipósit de la Recerca de Catalunya
instname

2-Phenylethynesulfonamide (PES) or pifithrin-μ is a promising anticancer agent with preferential toxicity for cancer cells. The type of cell death and the molecular cascades activated by this compound are controversial. Here, we demonstrate PES elic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::457df28750a029783bab55e9d0168eb3
https://doi.org/10.1016/j.bcp.2014.08.005

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Autophagy exacerbates caspase-dependent apoptotic cell death after short times of starvation

Autor: Jacint Boix, Judit Ribas, Paolo Mattiolo, Victor J. Yuste

Publikováno v: Repositorio Abierto de la UdL
Universitad de Lleida
Recercat. Dipósit de la Recerca de Catalunya
instname

Autophagy is generally regarded as a mechanism to promote cell survival. However, autophagy can occasionally be the mechanism responsible of cell demise. We have found that a concomitant depletion of glucose, nutrients and growth factors provoked cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0af54d2aaed7deb8edd6878a4c97c2fb
https://hdl.handle.net/10459.1/49017

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Pharmacological Modulation of Reactive Oxygen Species in Cancer Treatment

Autor: Judit Ribas, Jacint Boix, Paolo Mattiolo

Publikováno v: Repositorio Abierto de la UdL
Universitad de Lleida
ResearcherID
Recercat. Dipósit de la Recerca de Catalunya
instname

Aerobic metabolism of mammalian cells leads to the generation of reactive oxygen species (ROS). To cope with this toxicity, evolution provided cells with effective antioxidant systems like glutathione. Current anticancer therapies focus on the cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66779731d419d397a227810736cdde4f
http://hdl.handle.net/10459.1/48083

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7-Bromoindirubin-3′-oxime induces caspase-independent cell death

Autor: Jacint Boix, Karima Bettayeb, Frank Totzke, Alexios-Leandros Skaltsounis, Jan Mester, Xènia Garrofé-Ochoa, Laurent Meijer, Panos Polychronopoulos, Yoan Ferandin, Prokopios Magiatis, Judit Ribas, Marie Knockaert, Christoph Schächtele

Publikováno v: Repositorio Abierto de la UdL
Universitad de Lleida
Oncogene
Oncogene, Nature Publishing Group, 2006, 25 (47), pp.6304-18. ⟨10.1038/sj.onc.1209648⟩
Recercat. Dipósit de la Recerca de Catalunya
instname
Oncogene, 2006, 25 (47), pp.6304-18. ⟨10.1038/sj.onc.1209648⟩

Indirubin, an isomer of indigo, is a reported inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase-3 (GSK-3) as well as an agonist of the aryl hydrocarbon receptor (AhR). Indirubin is the active ingredient of a traditional Chines

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5905aba6a45aa9ccd7ee5d0dd9704b32
https://doi.org/10.1038/sj.onc.1209648

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The Absence of Oligonucleosomal DNA Fragmentation during Apoptosis of IMR-5 Neuroblastoma Cells

Autor: Jacint Boix, Isabel Sánchez-López, Jose R. Bayascas, Nuria Llecha, Victor J. Yuste, Joan X. Comella

Publikováno v: Journal of Biological Chemistry. 276:22323-22331

Caspase-activated DNase is responsible for the oligonucleosomal DNA degradation during apoptosis. DNA degradation is thought to be important for multicellular organisms to prevent oncogenic transformation or as a mechanism of viral defense. It has be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ca9bbfc9f63c875e79cd1de4923cddc8
https://doi.org/10.1074/jbc.m100072200

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Transcriptional modulation of apoptosis regulators by roscovitine and related compounds

Autor: Joan Gil, Jacint Boix, Xènia Garrofé-Ochoa, Ana M. Cosialls, Judit Ribas

Publikováno v: Recercat. Dipósit de la Recerca de Catalunya
instname
Repositorio Abierto de la UdL
Universitad de Lleida

Chemical inhibitors of cyclin-dependent kinase (CDK), like roscovitine, are promising drugs in thecontext of new cancer therapies. Roscovitine and related compounds, like seliciclib and olomoucine, are effective inducers of apoptosis in many prolifer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::768719206a8420f54b022f439eda8e2e
https://pubmed.ncbi.nlm.nih.gov/21505869

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Increased histone H1 ° expression in differentiating mouse erythroleukemia cells is related to decreased cell proliferation

Autor: Jacint Boix, Adolf Ruiz-Carrillo

Publikováno v: Experimental Cell Research. 201:531-534

The amount of histone H1 ° increases relative to other H1 subtypes in terminally differentiated cells, and its expression has been associated with the onset of differentiation. We have studied the kinetics of H1 ° accumulation in mouse erythroleuke

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b895eda4857bda4de8297d824a1269c5
https://doi.org/10.1016/0014-4827(92)90306-s

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7-Bromoindirubin-3'-oxime uncovers a serine protease-mediated paradigm of necrotic cell death

Autor: Josep E. Esquerda, Laurent Meijer, Victor J. Yuste, Jacint Boix, Judit Ribas, Xènia Garrofé-Ochoa

Publikováno v: Recercat. Dipósit de la Recerca de Catalunya
instname
Repositorio Abierto de la UdL
Universitad de Lleida

The new 7-bromoindirubin-3'-oxime (7BIO) compound induces caspase-independent cell death in all cell lines tested to date. Irrespective of the cell line, a 25 microM treatment for 24 h is lethal for the entire cell population. In SH-SY5Y and Jurkat c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cb7f779dfb18b4ef1ec93c51d3bb2b1
https://hdl.handle.net/10459.1/48092

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