Zobrazeno 1 - 10
of 198
pro vyhledávání: '"Jacek Zielonka"'
Publikováno v:
Redox Biology, Vol 70, Iss , Pp 103077- (2024)
Inflammatory diseases present a serious health challenge due to their widespread prevalence and the severe impact on patients' lives. In the quest to alleviate the burden of these diseases, nuclear factor erythroid 2-related factor 2 (Nrf2) has emerg
Externí odkaz:
https://doaj.org/article/702aed7988a64cfa8d40209b20ae9057
Autor:
Mette Sørensen, Göran Pershagen, Jesse Daniel Thacher, Timo Lanki, Benedikt Wicki, Martin Röösli, Danielle Vienneau, Manuella Lech Cantuaria, Jesper Hvass Schmidt, Gunn Marit Aasvang, Sadeer Al-Kindi, Michael T. Osborne, Philip Wenzel, Juan Sastre, Ingrid Fleming, Rainer Schulz, Omar Hahad, Marin Kuntic, Jacek Zielonka, Helmut Sies, Tilman Grune, Katie Frenis, Thomas Münzel, Andreas Daiber
Publikováno v:
Redox Biology, Vol 69, Iss , Pp 102995- (2024)
Transportation noise is a ubiquitous urban exposure. In 2018, the World Health Organization concluded that chronic exposure to road traffic noise is a risk factor for ischemic heart disease. In contrast, they concluded that the quality of evidence fo
Externí odkaz:
https://doaj.org/article/9422ae74b23f4599bfc0b65004a7dfa1
Autor:
Karolina Pierzchała, Marlena Pięta, Monika Rola, Małgorzata Świerczyńska, Angelika Artelska, Karolina Dębowska, Radosław Podsiadły, Jakub Pięta, Jacek Zielonka, Adam Sikora, Andrzej Marcinek, Radosław Michalski
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract MPO-derived oxidants including HOCl contribute to tissue damage and the initiation and propagation of inflammatory diseases. The search for small molecule inhibitors of myeloperoxidase, as molecular tools and potential drugs, requires the ap
Externí odkaz:
https://doaj.org/article/0d0c54d8360f4776869e515cc662ed47
Publikováno v:
Antioxidants, Vol 12, Iss 9, p 1660 (2023)
A family of seven NADPH oxidase enzymes (Nox1-5, Duox1-2) has been implicated in a variety of diseases, including inflammatory lung diseases, neurodegenerative diseases, cardiovascular diseases, and cancer. Here, we report the results of our studies
Externí odkaz:
https://doaj.org/article/68926ff5433147b8ac3898a3cdb9681b
Autor:
Nnamdi Uche, Qiang Dai, Shuping Lai, Kurt Kolander, Mai Thao, Elizabeth Schibly, Xavier Sendaydiego, Jacek Zielonka, Ivor J. Benjamin
Publikováno v:
Antioxidants, Vol 12, Iss 8, p 1585 (2023)
Doxorubicin (DOX), one of the most effective and widely used anticancer drugs, has the major limitation of cancer treatment-related cardiotoxicity (CTRTOX) in the clinic. Reactive oxygen species (ROS) generation and mitochondrial dysfunction are well
Externí odkaz:
https://doaj.org/article/71b6f0ff86774d1ea6015b264d5c301e
Autor:
Radosław Michalski, Renata Smulik-Izydorczyk, Jakub Pięta, Monika Rola, Angelika Artelska, Karolina Pierzchała, Jacek Zielonka, Balaraman Kalyanaraman, Adam Bartłomiej Sikora
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
Azanone (HNO, also known as nitroxyl) is the protonated form of the product of one-electron reduction of nitric oxide (•NO), and an elusive electrophilic reactive nitrogen species of increasing pharmacological significance. Over the past 20 years,
Externí odkaz:
https://doaj.org/article/1977414ea6e4468c93c4a0979a7609c0
Autor:
Qi Zhang, Gang Cheng, Jing Pan, Jacek Zielonka, Donghai Xiong, Charles R. Myers, Liang Feng, Song Seok Shin, Young Heui Kim, Dinh Bui, Ming Hu, Brian Bennett, Kathleen Schmainda, Yian Wang, Balaraman Kalyanaraman, Ming You
Publikováno v:
Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-14 (2020)
Abstract Background Magnolia extract (ME) is known to inhibit cancer growth and metastasis in several cell types in vitro and in animal models. However, there is no detailed study on the preventive efficacy of ME for oral cancer, and the key componen
Externí odkaz:
https://doaj.org/article/bb466bea91da46a79f89b7193724e2f4
Autor:
Mahmoud AbuEid, Donna M. McAllister, Laura McOlash, Megan Cleland Harwig, Gang Cheng, Donovan Drouillard, Kathleen A. Boyle, Micael Hardy, Jacek Zielonka, Bryon D. Johnson, R. Blake Hill, Balaraman Kalyanaraman, Michael B. Dwinell
Publikováno v:
iScience, Vol 24, Iss 6, Pp 102653- (2021)
Summary: Metabolic heterogeneity within the tumor microenvironment promotes cancer cell growth and immune suppression. We determined the impact of mitochondria-targeted complex I inhibitors (Mito-CI) in melanoma. Mito-CI decreased mitochondria comple
Externí odkaz:
https://doaj.org/article/3630e5359dc747fea35d724c0b59cc72
Autor:
Gang Cheng, Qi Zhang, Jing Pan, Yongik Lee, Olivier Ouari, Micael Hardy, Monika Zielonka, Charles R. Myers, Jacek Zielonka, Katherine Weh, Andrew C. Chang, Guoan Chen, Laura Kresty, Balaraman Kalyanaraman, Ming You
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Brain metastases are a major reason for lung cancer mortality. Here, the authors modify lonidamine to target mitochondria, and show its therapeutic efficacy in inhibiting lung cancer brain metastasis by inducing autophagic cell death in cancer cells.
Externí odkaz:
https://doaj.org/article/2a91f216e7964b0b95ec04c9938932cc
Autor:
Ksenija Vujacic-Mirski, Matthias Oelze, Ivana Kuntic, Marin Kuntic, Sanela Kalinovic, Huige Li, Jacek Zielonka, Thomas Münzel, Andreas Daiber
Publikováno v:
Antioxidants, Vol 11, Iss 6, p 1182 (2022)
Tetrahydrobiopterin (BH4) is an essential cofactor of all nitric oxide synthase isoforms, thus determination of BH4 levels can provide important mechanistic insight into diseases. We established a protocol for high-performance liquid chromatography/e
Externí odkaz:
https://doaj.org/article/ec3cfb4d93454ccd9f270cf071215463