Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jacek Stalewski"'
Autor:
Jacek Stalewski, Amy Y. Shih, Romeo Papazyan, Jocelyn Ramirez, Gerardo Ibanez, Peng Hsiao, Yong Yue, Jun Yin, Calen Badger, Shije Wu, Akemi Ueki, Bryan C. Fuchs, Marie-Laure Rives
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. :JPET-AR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c2bfe3253d27d6c53edcc766ab4550c
https://doi.org/10.1124/jpet.122.001554
https://doi.org/10.1124/jpet.122.001554
Autor:
Hiroe Tariga, Anastasia Velentza, Scott Rp McDonnell, Amy Klova, Suijin Yang, Adeela Kamal, Jacek Stalewski
Publikováno v:
Cancer Research. 80:588-588
Background: Bladder cancer is the sixth most common cancer in the United States, with over 80,000 new cases diagnosed each year. While patients often initially respond positively to treatment, it has been found that nearly 75% of patients diagnosed w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a3733e953054010509f0df4e55d8ebe
https://doi.org/10.1158/1538-7445.am2020-588
https://doi.org/10.1158/1538-7445.am2020-588
Publikováno v:
European journal of pharmacology. 824
Gonadotropin releasing hormone (GnRH) analogs have long been used in androgen deprivation therapy (ADT) in the treatment of prostate cancer. Chronic administration of either GnRH agonists or antagonists leads to suppression of testosterone production
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::029d89b767cfe28998583cee97c7ed0d
https://pubmed.ncbi.nlm.nih.gov/29378196
https://pubmed.ncbi.nlm.nih.gov/29378196
Autor:
László B. Tankó, Birgitte Buur Rasmussen, Wolfgang Koechling, Jacek Stalewski, Anders Sonesson
Publikováno v:
Drug Metabolism and Disposition. 39:1895-1903
Degarelix is a novel competitive gonadotropin-releasing hormone receptor blocker (antagonist). In this study, the nonclinical metabolism and excretion of degarelix was investigated in Sprague-Dawley rat, beagle dog, and cynomolgus monkey. Degarelix w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9029c71882e135318afd9cdeba9c805d
https://doi.org/10.1124/dmd.111.039883
https://doi.org/10.1124/dmd.111.039883
Autor:
Nadine Haase, Kristin Kräker, Ralf Dechend, Torsten Reinheimer, Jacek Stalewski, Ed Cable, Dominik N. Müller, Jennifer Liberal
Publikováno v:
Pregnancy Hypertension. 13:S64
Introduction Preeclampsia is a pregnancy-related disorder characterized by hypertension and excess protein excretion in the urine. It is the most common hypertensive disease of pregnancy and affects about 5–8% of pregnancies. The Renin-Angiotensin-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b07134ec69ad10553ba25947a61a1a5
https://doi.org/10.1016/j.preghy.2018.08.190
https://doi.org/10.1016/j.preghy.2018.08.190
Autor:
Jacek Stalewski
Publikováno v:
Tetrahedron Letters. 39:9523-9526
1-Cyano-2,2-diethoxycarbonyl cyclopropane was reacted with several nitroarenes under basic conditions. The reaction proceeded according to the vicarious nucleophilic substitution of hydrogen scheme; i.e. the initially formed σ-adducts underwent base
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11efbd3c3b04b55263a7c35c7d4cf3a9
https://doi.org/10.1016/s0040-4039(98)02114-5
https://doi.org/10.1016/s0040-4039(98)02114-5
Publikováno v:
Tetrahedron. 53:193-214
Two approaches to synthesis of 6-methoxy-1,3,4,5-tetrahydrobenz[cd]indol-4-amine 1 were developed Indolic precursor 21 of the tricyclic system was prepared via the VNS reaction, but attempts to execute the C ring closure failed. The other strategy, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e61259ebab568de8d37782da0bcd8a35
https://doi.org/10.1016/s0040-4020(96)00963-5
https://doi.org/10.1016/s0040-4020(96)00963-5
Autor:
Mieczyslaw Makosza, Jacek Stalewski
Publikováno v:
Tetrahedron. 51:7263-7276
The VNS reaction was used as key steps in synthesis of O-methylnordehydrobufotenine and its 8-methoxy isomer starting from simple benzene derivatives. Attempts to use nitrobenzoxazole derivatives as a starting material were made. Several approaches w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9bb604fc158cdb77f4799fd2f1b18167
https://doi.org/10.1016/0040-4020(95)00350-h
https://doi.org/10.1016/0040-4020(95)00350-h
Autor:
Mieczyslaw Makosza, Jacek Stalewski
Publikováno v:
Tetrahedron. 51:7277-7286
5- and 6-nitrobenzoxazoles 3 and 4 react with nucleophiles exclusively at C-2, giving ring opening products. If position 2- is blocked with phenyl substituent the reaction takes place in the carbocyclic ring affording the VNS products. 2-Methylthio-5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08401a29e4c8616258ae4800769a4fe9
https://doi.org/10.1016/0040-4020(95)00351-8
https://doi.org/10.1016/0040-4020(95)00351-8
Autor:
Jacek Stalewski, Mieczyslaw Makosza
Publikováno v:
ChemInform. 26
5- and 6-nitrobenzoxazoles 3 and 4 react with nucleophiles exclusively at C-2, giving ring opening products. If position 2- is blocked with phenyl substituent the reaction takes place in the carbocyclic ring affording the VNS products. 2-Methylthio-5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f6576fcf4a8e6dcfb421043f3767997
https://doi.org/10.1002/chin.199542137
https://doi.org/10.1002/chin.199542137