Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Jacek Stępniewski"'
Autor:
Urszula Florczyk-Soluch, Katarzyna Polak, Sarka Jelinkova, Iwona Bronisz-Budzyńska, Reece Sabo, Subhashini Bolisetty, Anupam Agarwal, Ewa Werner, Alicja Józkowicz, Jacek Stępniewski, Krzysztof Szade, Józef Dulak
Publikováno v:
Skeletal Muscle, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Background Adult muscle-resident myogenic stem cells, satellite cells (SCs), that play non-redundant role in muscle regeneration, are intrinsically impaired in Duchenne muscular dystrophy (DMD). Previously we revealed that dystrophic SCs exp
Externí odkaz:
https://doaj.org/article/726a69ef7b32411b9f36f14dae252c48
Autor:
Marta Przymuszała, Alicja Martyniak, Joanna Kwiatkowska, Jarosław Meyer-Szary, Karolina Śledzińska, Jolanta Wierzba, Józef Dulak, Urszula Florczyk-Soluch, Jacek Stępniewski
Publikováno v:
Stem Cell Research, Vol 76, Iss , Pp 103327- (2024)
Becker muscular dystrophy (BMD) is an X-linked recessive disorder caused by in-frame deletions in the dystrophin gene (DMD), leading to progressive muscle degeneration and weakness. We generated a human induced pluripotent stem cell (hiPSC) line from
Externí odkaz:
https://doaj.org/article/5986f4f03cf44232b9a3e192e86d605e
Publikováno v:
Stem Cell Research, Vol 68, Iss , Pp 103046- (2023)
miR-15a/16-1 cluster, composed of MIR15A and MIR16-1 genes located in close proximity on chromosome 13 was described to regulate post-natal cell cycle withdrawal of cardiomyocytes in mice. In humans, on the other hand, the level of miR-15a-5p and miR
Externí odkaz:
https://doaj.org/article/b0ec8889b4194714b81ed9bc3c17ec32
Autor:
Katarzyna Polak, Jacek Stępniewski, Aneta Ścieżyńska, Anna Podgórska, Józef Dulak, Urszula Florczyk-Soluch
Publikováno v:
Stem Cell Research, Vol 66, Iss , Pp 103004- (2023)
Duchenne muscular dystrophy (DMD), originating from the lack of functional dystrophin, clinically manifests as devastating disease of skeletal muscles with progressive cardiac involvement. HMOX1 promoter polymorphism may reflect different activity of
Externí odkaz:
https://doaj.org/article/a96d005295f846b3bfec6cf49b465e85
Autor:
Paulina Podkalicka, Olga Mucha, Katarzyna Kaziród, Krzysztof Szade, Jacek Stępniewski, Liudmyla Ivanishchuk, Hirofumi Hirao, Ewelina Pośpiech, Alicja Józkowicz, Jerzy W. Kupiec-Weglinski, Józef Dulak, Agnieszka Łoboda
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-19 (2022)
Abstract Although Duchenne muscular dystrophy (DMD) primarily affects muscle tissues, the alterations to systemic metabolism manifested in DMD patients contribute to the severe phenotype of this fatal disorder. We propose that microRNA-378a (miR-378)
Externí odkaz:
https://doaj.org/article/31f8767de0804f9ea3cdfb34755154d9
Autor:
Izabela Kraszewska, Mateusz Tomczyk, Kalina Andrysiak, Monika Biniecka, Anja Geisler, Henry Fechner, Michał Zembala, Jacek Stępniewski, Józef Dulak, Agnieszka Jaźwa-Kusior
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 1190-1201 (2020)
Systemically delivered adeno-associated viral vector serotype 9 (AAV9) effectively transduces murine heart, but provides transgene expression also in liver and skeletal muscles. Improvement of the selectivity of transgene expression can be achieved t
Externí odkaz:
https://doaj.org/article/e31943af4dc24b31b50d9af45a05ad0e
Autor:
Kalina Andrysiak, Alicja Martyniak, Anna Potulska-Chromik, Anna Kostera-Pruszczyk, Jacek Stępniewski, Józef Dulak
Publikováno v:
Stem Cell Research, Vol 57, Iss , Pp 102563- (2021)
Spinal Muscular Atrophy (SMA) is a genetic neuromuscular disease caused by mutations inSMN1 gene encoding survival motor neuron (SMN) protein. Lack of this protein leads to progressive loss of motor neurons and therefore to gradual loss of signal tra
Externí odkaz:
https://doaj.org/article/7bc2e014b8df4854b25bfcb570300c17
Publikováno v:
Stem Cell Research, Vol 56, Iss , Pp 102529- (2021)
LAMA2-related muscular dystrophy (LAMA2-MD) results from mutations in LAMA2 gene, encoding laminin α-2. It is a congenital disease characterized by muscle wasting, with the most severe version being diagnosed within first few months after birth. To
Externí odkaz:
https://doaj.org/article/602f48e0b6f449c78a24864f26c7613f
Autor:
Agata Barzowska, Barbara Pucelik, Katarzyna Pustelny, Alex Matsuda, Alicja Martyniak, Jacek Stępniewski, Anna Maksymiuk, Maciej Dawidowski, Ulli Rothweiler, Józef Dulak, Grzegorz Dubin, Anna Czarna
Publikováno v:
Cells, Vol 10, Iss 9, p 2263 (2021)
The rising prevalence of diabetes is threatening global health. It is known not only for the occurrence of severe complications but also for the SARS-Cov-2 pandemic, which shows that it exacerbates susceptibility to infections. Current therapies focu
Externí odkaz:
https://doaj.org/article/57e400e4727d4c7ea312dfee0248f600
Autor:
Paulina Koczurkiewicz-Adamczyk, Katarzyna Klaś, Agnieszka Gunia-Krzyżak, Kamil Piska, Kalina Andrysiak, Jacek Stępniewski, Sławomir Lasota, Katarzyna Wójcik-Pszczoła, Józef Dulak, Zbigniew Madeja, Elżbieta Pękala
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12, p 6217 (2021)
Doxorubicin (DOX) is a widely used anticancer drug. However, its clinical use is severely limited due to drug-induced cumulative cardiotoxicity, which leads to progressive cardiomyocyte dysfunction and heart failure. Enormous efforts have been made t
Externí odkaz:
https://doaj.org/article/925108ec0bb347078433456221f524be