Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Jacek Sapa"'
Autor:
Monika Kubacka, Barbara Nowak, Monika Zadrożna, Małgorzata Szafarz, Gniewomir Latacz, Henryk Marona, Jacek Sapa, Szczepan Mogilski, Marek Bednarski, Magdalena Kotańska
Publikováno v:
Metabolites, Vol 13, Iss 11, p 1130 (2023)
Excessive fructose consumption may lead to metabolic syndrome, metabolic dysfunction-associated fatty liver disease (MAFLD) and hypertension. α1-adrenoceptors antagonists are antihypertensive agents that exert mild beneficial effects on the metaboli
Externí odkaz:
https://doaj.org/article/d003b1d9fb2148d98d4eab2769f57ff8
Autor:
Szczepan Mogilski, Monika Kubacka, Artur Świerczek, Elżbieta Wyska, Katarzyna Szczepańska, Jacek Sapa, Katarzyna Kieć-Kononowicz, Dorota Łażewska
Publikováno v:
Pharmaceuticals, Vol 16, Iss 10, p 1481 (2023)
Itch and pain are closely related but distinct sensations that share largely overlapping mediators and receptors. We hypothesized that the novel, multi-target compound E153 has the potential to attenuate pain and pruritus of different origins. After
Externí odkaz:
https://doaj.org/article/6cd04dd7b53146d69e2538b00099cbd6
Autor:
Elżbieta Żmudzka, Klaudia Lustyk, Kinga Sałaciak, Agata Siwek, Jolanta Jaśkowska, Marcin Kołaczkowski, Jacek Sapa, Karolina Pytka
Publikováno v:
Pharmaceuticals, Vol 16, Iss 3, p 399 (2023)
Memory impairments constitute a significant problem worldwide, and the COVID-19 pandemic dramatically increased the prevalence of cognitive deficits. Patients with cognitive deficits, specifically memory disturbances, have underlying comorbid conditi
Externí odkaz:
https://doaj.org/article/14281d0bf07a4c3fa2b1e60717b985a3
Autor:
Elżbieta Żmudzka, Klaudia Lustyk, Monika Głuch-Lutwin, Małgorzata Wolak, Jolanta Jaśkowska, Marcin Kołaczkowski, Jacek Sapa, Karolina Pytka
Publikováno v:
Pharmaceuticals, Vol 16, Iss 2, p 175 (2023)
Depression, anxiety, and schizophrenia may coexist in psychiatric patients. Moreover, these disorders are very often associated with cognitive impairments. However, pharmacotherapy of these conditions remains challenging due to limited drug effective
Externí odkaz:
https://doaj.org/article/01f15a7cad704a1ca5769770a4dc6d63
Autor:
Kamil Mika, Małgorzata Szafarz, Marek Bednarski, Kamil Kuder, Katarzyna Szczepańska, Krzysztof Pociecha, Bartosz Pomierny, Katarzyna Kieć-Kononowicz, Jacek Sapa, Magdalena Kotańska
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 142, Iss , Pp 111952- (2021)
Aims: One of the therapeutic approaches in the treatment of obesity is the use of histamine H3 receptor ligands. Histamine plays a significant role in eating behavior because it causes a loss of appetite and is considered to be a satiety signal relea
Externí odkaz:
https://doaj.org/article/6a3c5ca87e4d48f58209fd85d18e7a2d
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 141, Iss , Pp 111892- (2021)
It is important to search for a promising therapeutic target or small molecules that can control excessive eating since limiting the intake of foods, especially tasty ones, could be effective in the treatment or prevention of obesity. Some studies in
Externí odkaz:
https://doaj.org/article/8cc6876e60c24acfb9d510e8af751feb
Autor:
Klaudia Lustyk, Kinga Sałaciak, Agata Siwek, Barbara Filipek, Jacek Sapa, Henryk Marona, Dorota Żelaszczyk, Karolina Pytka
Publikováno v:
Pharmaceuticals, Vol 15, Iss 10, p 1256 (2022)
Arrhythmia, an irregular heartbeat, might be a life-threatening condition but also a risk factor for stroke or worsen the prognosis after myocardial infarction. The limited efficacy and proarrhythmic potential of the available drugs require searching
Externí odkaz:
https://doaj.org/article/4e067cc7310447c48c9235658364a46b
Autor:
Magdalena Kotańska, Małgorzata Szafarz, Kamil Mika, Anna Dziubina, Marek Bednarski, Christa E. Müller, Jacek Sapa, Katarzyna Kieć-Kononowicz
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 135, Iss , Pp 111164- (2021)
A2B adenosine receptors are present in a wide spectrum of tissues, especially on cells of the immune system. Since these particular receptors have the lowest, of all adenosine receptor subtypes, affinity for adenosine they are believed to play a spec
Externí odkaz:
https://doaj.org/article/42bf36b944a54b8c90fcc8bf52c4c0e7
Autor:
Magdalena Kotańska, Anna Dziubina, Małgorzata Szafarz, Kamil Mika, Karolina Reguła, Marek Bednarski, Małgorzata Zygmunt, Anna Drabczyńska, Jacek Sapa, Katarzyna Kieć-Kononowicz
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0229806 (2020)
The A2 adenosine receptors play an important role, among others, in the regulation of inflammatory process and glucose homeostasis in diabetes and obesity. Thus, the presented project evaluated of influence of the selective antagonist of A2A adenosin
Externí odkaz:
https://doaj.org/article/2d0c6a2ccf8848c79ffcb34e1aaa30e1
Autor:
Monika Marcinkowska, Magdalena Kotańska, Agnieszka Zagórska, Joanna Śniecikowska, Monika Kubacka, Agata Siwek, Adam Bucki, Maciej Pawłowski, Marek Bednarski, Jacek Sapa, Małgorzata Starek, Monika Dąbrowska, Marcin Kołaczkowski
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 536-545 (2018)
Despite the substantial clinical success of aspirin and clopidogrel in secondary prevention of ischemic stroke, up to 40% of patients remain resistant to the available antiplatelet treatment. Therefore, there is an urgent clinical need to develop nov
Externí odkaz:
https://doaj.org/article/ca47822105e94d8aa84ccd74b1b779d4