Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Jacek Puchałka"'
Autor:
Marcin Łyszkiewicz, Natalia Ziętara, Laura Frey, Ulrich Pannicke, Marcel Stern, Yanshan Liu, Yanxin Fan, Jacek Puchałka, Sebastian Hollizeck, Ido Somekh, Meino Rohlfs, Tuğba Yilmaz, Ekrem Ünal, Musa Karakukcu, Türkan Patiroğlu, Christina Kellerer, Ebru Karasu, Karl-Walter Sykora, Atar Lev, Amos Simon, Raz Somech, Joachim Roesler, Manfred Hoenig, Oliver T. Keppler, Klaus Schwarz, Christoph Klein
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
FCH domain only 1 (FCHO1) is a key molecule involved in clathrin-mediated endocytosis (CME). Here, the authors report homozygous FCHO1 mutations in individuals with variable T and B cell lymphopenia, which are associated with loss-of-function of FCHO
Externí odkaz:
https://doaj.org/article/74724d48da6d4ad88e09abfe678d8216
Autor:
Marcin Łyszkiewicz, Samantha J Winter, Katrin Witzlau, Lisa Föhse, Rebecca Brownlie, Jacek Puchałka, Nikita A Verheyden, Heike Kunze-Schumacher, Esther Imelmann, Jonas Blume, Solaiman Raha, Takashi Sekiya, Akihiko Yoshimura, Jochen T Frueh, Evelyn Ullrich, Jochen Huehn, Siegfried Weiss, Maximiliano G Gutierrez, Immo Prinz, Rose Zamoyska, Natalia Ziętara, Andreas Krueger
Publikováno v:
PLoS Biology, Vol 17, Iss 3, p e2006716 (2019)
The interdependence of selective cues during development of regulatory T cells (Treg cells) in the thymus and their suppressive function remains incompletely understood. Here, we analyzed this interdependence by taking advantage of highly dynamic cha
Externí odkaz:
https://doaj.org/article/49acf38f9aa2422c892b9dbd30a0f152
Autor:
Marcin Łyszkiewicz, Natalia Ziętara, Laura Frey, Ulrich Pannicke, Marcel Stern, Yanshan Liu, Yanxin Fan, Jacek Puchałka, Sebastian Hollizeck, Ido Somekh, Meino Rohlfs, Tuğba Yilmaz, Ekrem Ünal, Musa Karakukcu, Türkan Patiroğlu, Christina Kellerer, Ebru Karasu, Karl-Walter Sykora, Atar Lev, Amos Simon, Raz Somech, Joachim Roesler, Manfred Hoenig, Oliver T. Keppler, Klaus Schwarz, Christoph Klein
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/6a981817becc4e8ca162ede7a2b51a17
Autor:
Mariette Barbier, F Heath Damron, Piotr Bielecki, María Suárez-Diez, Jacek Puchałka, Sebastian Albertí, Vitor Martins Dos Santos, Joanna B Goldberg
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89941 (2014)
Pseudomonas aeruginosa is a highly versatile opportunistic pathogen capable of colonizing multiple ecological niches. This bacterium is responsible for a wide range of both acute and chronic infections in a variety of hosts. The success of this micro
Externí odkaz:
https://doaj.org/article/2049a7568cc14ca88a50993dc5a3d56b
Autor:
Judith A H Wodke, Jacek Puchałka, Maria Lluch‐Senar, Josep Marcos, Eva Yus, Miguel Godinho, Ricardo Gutiérrez‐Gallego, Vitor A P Martins dos Santos, Luis Serrano, Edda Klipp, Tobias Maier
Publikováno v:
Molecular Systems Biology, Vol 9, Iss 1, Pp n/a-n/a (2013)
Mycoplasma pneumoniae, a threatening pathogen with a minimal genome, is a model organism for bacterial systems biology for which substantial experimental information is available. With the goal of understanding the complex interactions underlying its
Externí odkaz:
https://doaj.org/article/c236d8f2c5a84d8ca86c47a1a6df1de4
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74838 (2013)
Here we describe a novel, spontaneous, 4035 basepairs long deletion in the DNA cross-link repair 1C (Dclre1c)-locus in C57BL/6-mice, which leads to loss of exons 10 and 11 of the gene encoding for Artemis, a protein involved into V(D) J-recombination
Externí odkaz:
https://doaj.org/article/adf530ac668944b498fd006b1e8f627a
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 3, p e1001116 (2011)
In the past decade, over 50 genome-scale metabolic reconstructions have been built for a variety of single- and multi- cellular organisms. These reconstructions have enabled a host of computational methods to be leveraged for systems-analysis of meta
Externí odkaz:
https://doaj.org/article/8e39a64463804b77a917572da591ad7a
Autor:
Piotr Bielecki, Jacek Puchałka, Melissa L Wos-Oxley, Holger Loessner, Justyna Glik, Marek Kawecki, Mariusz Nowak, Burkhard Tümmler, Siegfried Weiss, Vítor A P Martins dos Santos
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24235 (2011)
Pseudomonas aeruginosa is a threatening, opportunistic pathogen causing disease in immunocompromised individuals. The hallmark of P. aeruginosa virulence is its multi-factorial and combinatorial nature. It renders such bacteria infectious for many or
Externí odkaz:
https://doaj.org/article/ca099fbe2614491292fb9c35704727da
Autor:
Jacek Puchałka, Matthew A Oberhardt, Miguel Godinho, Agata Bielecka, Daniela Regenhardt, Kenneth N Timmis, Jason A Papin, Vítor A P Martins dos Santos
Publikováno v:
PLoS Computational Biology, Vol 4, Iss 10, p e1000210 (2008)
A cornerstone of biotechnology is the use of microorganisms for the efficient production of chemicals and the elimination of harmful waste. Pseudomonas putida is an archetype of such microbes due to its metabolic versatility, stress resistance, amena
Externí odkaz:
https://doaj.org/article/5cea604e5daa481dae20a13023248a56
Autor:
Yanxin Fan, Ido Somekh, Laura M. Frey, Joachim Roesler, Ulrich Pannicke, Ekrem Unal, Marcel Stern, Sebastian Hollizeck, Meino Rohlfs, Raz Somech, Christina Kellerer, Oliver T. Keppler, Klaus Schwarz, Jacek Puchałka, Manfred Hoenig, Marcin Łyszkiewicz, Tuğba Yilmaz, Turkan Patiroglu, Musa Karakukcu, Amos J. Simon, Natalia Ziętara, Atar Lev, Karl-Walter Sykora, Christoph Klein, Ebru Karasu, Yanshan Liu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Clathrin-mediated endocytosis (CME) is critical for internalisation of molecules across cell membranes. The FCH domain only 1 (FCHO1) protein is key molecule involved in the early stages of CME formation. The consequences of mutations in FCHO1 in hum