Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Jacek Polosak"'
Autor:
Magdalena Owczarz, Jacek Połosak, Anna Domaszewska-Szostek, Paulina Kołodziej, Alina Kuryłowicz, Monika Puzianowska-Kuźnicka
Publikováno v:
Epigenetics, Vol 15, Iss 12, Pp 1336-1347 (2020)
Sirtuin 6 (SIRT6) exerts a protective effect on health and extends the lives of model organisms. We, therefore, aimed to clarify whether age-related epigenetic drift is responsible for differences in SIRT6 expression in peripheral blood mononuclear c
Externí odkaz:
https://doaj.org/article/d89f278e290845789405789c57d2aacf
Autor:
Krzysztof Laudanski, Mateusz Zawadka, Jacek Polosak, Jaymin Modi, Matthew DiMeglio, Jacob Gutsche, Wilson Y. Szeto, Monika Puzianowska-Kuznicka
Publikováno v:
Journal of Translational Medicine, Vol 16, Iss 1, Pp 1-13 (2018)
Abstract Background It has been shown that severe insult to the immune system may trigger prolonged macrophage characteristics associated with excessive release of monocyte colony stimulating factor (M-CSF). However, it is unclear how persistent is t
Externí odkaz:
https://doaj.org/article/3b96f1a0692348e0b95fe37cf009a03b
Autor:
Krzysztof Laudanski, Natalia Lapko, Mateusz Zawadka, Jacek Polosak, George S. Worthen, Gwenn Danet-Desnoyers, Monika Puzianowska-Kuźnicka
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
The duration of post-sepsis long-term immune suppression is poorly understood. Here, we focused on the role of monocytes (MO) as the pivotal cells for long-term regulation of post-sepsis milieu. Lost ability of MO to adapt is seen in several acute co
Externí odkaz:
https://doaj.org/article/fa12137d080145ccbe3fcb261facd607
Autor:
Monika Puzianowska-Kuznicka, Eliza Pawlik-Pachucka, Magdalena Owczarz, Monika Budzińska, Jacek Polosak
Publikováno v:
International Journal of Endocrinology, Vol 2013 (2013)
Small-molecule hormones play crucial roles in the development and in the maintenance of an adult mammalian organism. On the molecular level, they regulate a plethora of biological pathways. Part of their actions depends on their transcription-regulat
Externí odkaz:
https://doaj.org/article/a5a8b36c6c434ac58a516c1b4be01561
Autor:
Anna Domaszewska-Szostek, Paulina Kolodziej-Wojnar, Marta Cąkała-Jakimowicz, Olga Bujanowska, Jacek Polosak, Monika Puzianowska-Kuznicka, Zofia Wicik, Joanna Borkowska
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 78, p 78 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 1
International Journal of Molecular Sciences
Volume 22
Issue 1
5-Hydroxymethylcytosine (5hmC) is a functionally active epigenetic modification. We analyzed whether changes in DNA 5-hydroxymethylation are an element of age-related epigenetic drift. We tested primary fibroblast cultures originating from individual
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3703addc3c728c8b0a7fbe131f81c8a1
https://www.mdpi.com/1422-0067/22/1/78
https://www.mdpi.com/1422-0067/22/1/78
Autor:
Joanna Borkowska, Monika Puzianowska-Kuznicka, Marek Stańczyk, Olga Buyanovskaya, Anna Domaszewska-Szostek, Paulina Kołodziej, Bartłomiej Noszczyk, Zofia Wicik, Lukasz Charzewski, Jacek Polosak
Publikováno v:
Epigenomics. 12(5)
Aim: To clarify mechanisms affecting the level and distribution of 5-hydroxymethylcytosine (5hmC) during aging. Materials & methods: We examined levels and genomic distribution of 5hmC along with the expression of ten–eleven translocation methylcyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9babcabf39234672e0fbfcb61fa2a5f
https://pubmed.ncbi.nlm.nih.gov/32031421
https://pubmed.ncbi.nlm.nih.gov/32031421
Autor:
Paulina Kołodziej, Alina Kurylowicz, Anna Domaszewska-Szostek, Monika Puzianowska-Kuźnicka, Jacek Polosak, Magdalena Owczarz
Publikováno v:
Epigenetics
Sirtuin 6 (SIRT6) exerts a protective effect on health and extends the lives of model organisms. We, therefore, aimed to clarify whether age-related epigenetic drift is responsible for differences in SIRT6 expression in peripheral blood mononuclear c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a005e3d3e464b920c5ad2010ce2e436c
Autor:
Matthew DiMeglio, Jacek Polosak, Mateusz Zawadka, Wilson Y. Szeto, Jaymin Modi, Jacob T. Gutsche, Monika Puzianowska-Kuznicka, Krzysztof Laudanski
Publikováno v:
Journal of Translational Medicine, Vol 16, Iss 1, Pp 1-13 (2018)
Journal of Translational Medicine
Journal of Translational Medicine
Background It has been shown that severe insult to the immune system may trigger prolonged macrophage characteristics associated with excessive release of monocyte colony stimulating factor (M-CSF). However, it is unclear how persistent is the macrop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::772922d023b7d79e3739d377fc9b2943
https://doi.org/10.1186/s12967-018-1518-3
https://doi.org/10.1186/s12967-018-1518-3
Autor:
Magdalena Owczarz, Monika Puzianowska-Kuznicka, Magdalena Gewartowska, Joanna Borkowska, Przemyslaw Slusarczyk, Jacek Polosak, Monika Budzinska, Anna Domaszewska-Szostek
Increased expression of sirtuins lowers the risk of age-related diseases, while their role in the regulation of longevity is not firmly established. Since aging is associated with immunosenescence, we tested whether sirtuin expression was modified in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9dbe615cb864bf3e8dd592d8dcc93ec
https://europepmc.org/articles/PMC5544174/
https://europepmc.org/articles/PMC5544174/
Autor:
Magdalena Owczarz, Alina Kurylowicz, Malgorzata Roszkowska-Gancarz, Marta Jonas, Małgorzata Mossakowska, Monika Puzianowska-Kuznicka, Edward Franek, Przemyslaw Slusarczyk, Jacek Polosak
Publikováno v:
Geriatrics & Gerontology International. 15:365-371
Aim Aging is usually associated with hyperleptinemia and leptin resistance, both increasing the risk of age-related diseases. It was relevant to establish if healthily aging, non-obese individuals develop changes in leptin, the soluble leptin recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09c7b3952cde16259def0061bc51c312
https://doi.org/10.1111/ggi.12267
https://doi.org/10.1111/ggi.12267