Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Jacek Lubkowski"'
Autor:
Betsegaw Lemma, Di Zhang, Ganga B. Vamisetti, Bryan G. Wentz, Hiroaki Suga, Ashraf Brik, Jacek Lubkowski, David Fushman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Post-translational modification of proteins with polyubiquitin chains is a critical cellular signaling mechanism in eukaryotes with implications in various cellular states and processes. Unregulated ubiquitin-mediated protein degradation can
Externí odkaz:
https://doaj.org/article/9058e9e4ef084ba383c97031acda0042
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Abstract The mechanism of catalysis by the l-glutaminase-asparaginase from Pseudomonas 7A (PGA) was investigated using structural, mass spectrometry, and kinetic data. We had previously proposed mechanism of hydrolysis of l-Asn by the type II l-aspar
Externí odkaz:
https://doaj.org/article/f83228abc94f412f8961e8c39ea4a376
Autor:
Oleg Chertov, Ning Zhang, Xin Chen, Joost J Oppenheim, Jacek Lubkowski, Connor McGrath, Raymond C Sowder, Bruce J Crise, Anatoli Malyguine, Michele A Kutzler, Amber D Steele, Earl E Henderson, Thomas J Rogers
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e14474 (2011)
The sequential interaction of the envelope glycoprotein of the human immunodeficiency virus type 1 (HIV-1) with CD4 and certain chemokine coreceptors initiates host cell entry of the virus. The appropriate chemokines have been shown to inhibit viral
Externí odkaz:
https://doaj.org/article/c33e88f88d76462f85eb5258f040392a
Publikováno v:
FEBS lettersReferences. 596(23)
Bacterial L-asparaginases have been used for over 40 years as anticancer drugs. Ardalan et al. (Medical Hypotheses 112, 7-17, 2018) proposed that the V27T mutant of Escherichia coli type II L-asparaginase, EcAII(V27T), should display altered biophysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c501abe4c05fb4bc02721a3b82970e6
https://pubmed.ncbi.nlm.nih.gov/36310372
https://pubmed.ncbi.nlm.nih.gov/36310372
Autor:
Alexander Wlodawer, Jacek Lubkowski
Publikováno v:
The FEBS Journal. 288:4183-4209
L-asparaginase (a hydrolase converting L-asparagine to L-aspartic acid) was the first enzyme to be used in clinical practice as an anticancer agent after its approval in 1978 as a component of a treatment protocol for childhood acute lymphoblastic le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a427b04f080e3c6e4b12e4b969f535f
https://doi.org/10.1111/febs.16042
https://doi.org/10.1111/febs.16042
Autor:
Jacek Lubkowski, Juan M. Vanegas, Andriy Anishkin, Sergei Sukharev, John N. Weinstein, David Fushman, Alexander Wlodawer, Wai Kin Chan, Susan B. Rempe, Philip L. Lorenzi
Publikováno v:
Biochemistry. 59:1927-1945
Two bacterial type II l-asparaginases, from Escherichia coli and Dickeya chrysanthemi, have played a critical role for more than 40 years as therapeutic agents against juvenile leukemias and lympho...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec41c86adf575e999a0b77442b75c61c
https://doi.org/10.1021/acs.biochem.0c00116
https://doi.org/10.1021/acs.biochem.0c00116
Autor:
Alexander Wlodawer, Jacek Lubkowski
Publikováno v:
Protein Sci
Twenty crystal structures of the complexes of l-asparaginase with l-Asn, l-Asp, and succinic acid that are currently available in the Protein Data Bank, as well as 11 additional structures determined in the course of this project, were analyzed in or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::818d11d030469b118c45b5f51a84d0f9
https://doi.org/10.1002/pro.3709
https://doi.org/10.1002/pro.3709
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 78:a293-a293
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a29730c3da715621bd1190cbf0e9fb4
https://doi.org/10.1107/s2053273322097066
https://doi.org/10.1107/s2053273322097066
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
The mechanism of catalysis by the l-glutaminase-asparaginase from Pseudomonas 7A (PGA) was investigated using structural, mass spectrometry, and kinetic data. We had previously proposed mechanism of hydrolysis of l-Asn by the type II l-asparaginase f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9c4c03b45732021f27a68be2f98c3a9
https://doi.org/10.1038/s41598-020-74480-4
https://doi.org/10.1038/s41598-020-74480-4
Autor:
Jacek Lubkowski, Andriy Anishkin, Alexander Wlodawer, Cem Sonmez, Sergei V. Kotenko, Sergey V. Smirnov
Publikováno v:
The Journal of Immunology. 201:2082-2093
Crystal structure of the ternary complex of human IL-24 with two receptors, IL-22R1 and IL-20R2, has been determined at 2.15 Å resolution. A crystallizable complex was created by a novel approach involving fusing the ligand with a flexible linker to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8fa097b0d4504e21e04988fe7b10b39
https://doi.org/10.4049/jimmunol.1800726
https://doi.org/10.4049/jimmunol.1800726