Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Jacek Krzeminski"'
Autor:
Dhwani Patel, Iain A. Murray, Fangcong Dong, Andrew J. Annalora, Krishne Gowda, Denise M. Coslo, Jacek Krzeminski, Imhoi Koo, Fuhua Hao, Shantu G. Amin, Craig B. Marcus, Andrew D. Patterson, Gary H. Perdew
Publikováno v:
Metabolites, Vol 13, Iss 9, p 985 (2023)
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that plays an important role in gastrointestinal barrier function, tumorigenesis, and is an emerging drug target. The resident microbiota is capable of metabolizing trypto
Externí odkaz:
https://doaj.org/article/eb93d6bc3a4946b3bf3803357f3aeec6
Publikováno v:
Chemical Research in Toxicology. 35:2296-2309
1-Nitropyrene (1-NP) and 1,8-dinitropyrene (1,8-DNP) are diesel exhaust constituents and are classified by the International Agency for Research on Cancer as probable (Group 2A) or possible (Group 2B) human carcinogens. These nitroarenes undergo meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31dd1ea34b95c201ca977f437eb8309b
https://doi.org/10.1021/acs.chemrestox.2c00271
https://doi.org/10.1021/acs.chemrestox.2c00271
Autor:
Kun-Ming Chen, Yuan-Wan Sun, Nicolle M Krebs, Dongxiao Sun, Jacek Krzeminski, Lisa Reinhart, Krishne Gowda, Shantu Amin, Susan Mallery, John P Richie, Karam El-Bayoumy
Publikováno v:
Carcinogenesis
Polycyclic aromatic hydrocarbons (PAHs) are recognized as potential etiological agents in the development of oral cancer in smokers. In particular, benzo[a]pyrene (B[a]P) and dibenzo[def,p]chrysene (DB[a,l]P) are detected in cigarette smoke and the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b237e67bd0d62d4aff65e2998cce3010
https://doi.org/10.1093/carcin/bgac058
https://doi.org/10.1093/carcin/bgac058
Publikováno v:
Cancer Research. 83:1650-1650
Kevetrin is an investigational new drug in phase I clinical trial on solid tumors (NCT01664000). It has shown its efficacy in various tumors, including lung, breast, colon, and ovarian cancer cell and xenograft models, both in a p53-dependent and -in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2475f60196602c8b13c9ecc6ff043a4
https://doi.org/10.1158/1538-7445.am2023-1650
https://doi.org/10.1158/1538-7445.am2023-1650
Publikováno v:
Cancer Research. 82:5452-5452
Leonurine is an active alkaloid that is extracted from Traditional Chinese Medicine Herba leonuri. It has been reported to be beneficial for cardiovascular diseases, including atherosclerosis, acute and chronic myocardial infarction (MI), and ischemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efa340f6a3d95b22de57c4a39c2e169b
https://doi.org/10.1158/1538-7445.am2022-5452
https://doi.org/10.1158/1538-7445.am2022-5452
Autor:
Karen Creswell, Marcin Dyba, Shantu Amin, Heidi Coia, Sumire Noguchi, David C.H. Yang, Jishen Pan, Jacek Krzeminski, Brandon Da Silva, Deborah L. Berry, Dhimant Desai, Fung Lung Chung, Yanqi Hou
Publikováno v:
Chemical Research in Toxicology. 31:772-783
Lipid peroxidation of polyunsaturated fatty acids (PUFAs) is an endogenous source of α,β-unsaturated aldehydes that react with DNA producing a variety of cyclic adducts. The mutagenic cyclic adducts, specifically those derived from oxidation of ω-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d06c9368bacc8dbe7a84badc72169cdd
https://doi.org/10.1021/acs.chemrestox.8b00111
https://doi.org/10.1021/acs.chemrestox.8b00111
Publikováno v:
Chemical Research in Toxicology. 30:1168-1176
Benzo[a]pyrene, a potent human carcinogen, is metabolized in vivo to a diol epoxide that reacts with the N2-position of guanine to produce N2-BP-dG adducts. These adducts are mutagenic causing G to T transversions. These adducts block replicative pol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25ab7f58db738ad0e82e10b9ca39b7f6
https://doi.org/10.1021/acs.chemrestox.6b00466
https://doi.org/10.1021/acs.chemrestox.6b00466
Autor:
Raghavendra Gowda, Saketh S. Dinavahi, Shantu Amin, Jacek Krzeminski, Sreedhara R. Voleti, Madhu Babu Battu, Gajanan S. Inamdar, Gavin P. Robertson, Omer F. Kuzu
Publikováno v:
Oncotarget
// Raghavendra Gowda 1, 5, 6, 7 , Gajanan S. Inamdar 1 , Omer Kuzu 1 , Saketh S. Dinavahi 1 , Jacek Krzeminski 1 , Madhu Babu Battu 8 , Sreedhara R. Voleti 8 , Shantu Amin 1 , Gavin P. Robertson 1, 2, 3, 4, 5, 6, 7 1 Department of Pharmacology, The P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f8daeaece70e3ad1f0ec828b8f6618e
https://doi.org/10.18632/oncotarget.16002
https://doi.org/10.18632/oncotarget.16002
Autor:
Arun Sharma, David B. Stewart, Jacek Krzeminski, John P. Hegarty, Diana Guzman-Villanueva, Volkmar Weissig
Publikováno v:
International Journal of Nanomedicine. 11:3607-3619
Despite being a conceptually appealing alternative to conventional antibiotics, a major challenge toward the successful implementation of antisense treatments for bacterial infections is the development of efficient oligonucleotide delivery systems.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc3293b28909fb84a15e1a83940d069e
https://doi.org/10.2147/ijn.s109600
https://doi.org/10.2147/ijn.s109600
Publikováno v:
The Journal of antibiotics
Conventional antibiotics for C. difficile infection (CDI) have mechanisms of action without organismal specificity, potentially perpetuating the dysbiosis contributing to CDI, making antisense approaches an attractive alternative. Here, three (APDE-8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::968e15c5803cceea2c4703b0cf3d67d7
https://pubmed.ncbi.nlm.nih.gov/29674636
https://pubmed.ncbi.nlm.nih.gov/29674636