Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jacek J. Kozioł"'
Publikováno v:
Micro & Nano Letters, Vol 16, Iss 10, Pp 515-523 (2021)
Chlorambucil is a nitrogen mustard alkylating agent used for the treatment of various malignant and non‐malignant cancers. The use of the chemotherapeutic is limited by its toxic side effects which precludes the use of optimal doses. It was decided
Publikováno v:
Pharmaceutical Chemistry Journal. 53:527-534
In this study, iron oxide (Fe3O4) nanoparticles were synthesized using the Massart co-precipitation method followed by surface coating with dextran. Next, coated magnetic nanoparticles (MNPs) were functionalized by diclofenac and dopamine attachment
Publikováno v:
Biological Letters, Vol 54, Iss 1, Pp 13-20 (2019)
Lactobacillus brevis PCM 2570 is a strain of lactic acid bacteria, i.e. probiotic bacteria whose major fermentation product is lactic acid. The efficiency of lactic acid production is limited by the value of ambient pH. This study aimed to increase t
Publikováno v:
Pharmaceutical Chemistry Journal. 52:257-265
In this study, magnetic nanoparticles were functionalized with dextran and immobilized ibuprofen, diclofenac, and dopamine in order to investigate the diffusion of drugs through a dialysis membrane under biological conditions such as a temperature of
Autor:
Julia Nowak-Jary, Jacek J. Kozioł
Publikováno v:
Micro & Nano Letters. 13:316-320
Drug distribution in an organism depends largely on the binding degree of drugs with blood serum proteins like albumin. Only free fraction of the drug can induce a therapeutic effect. A different affinity of particular drugs to proteins is also one o
Publikováno v:
Journal of Nano Research. 48:114-124
In this paper we report the biological synthesis of gold nanoparticles (GNPs) by the reduction of gold ions using a suspension and supernatant of P. aeruginosa. The biosynthesis method was straightforward and yielded good results without using toxic
Publikováno v:
Micro & Nano Letters. 12:170-174
A broad and significant group of drugs include peptide compounds. The peptides are also crucial in the delivery of amino acid analogues, which are important inhibitors of pathogenic cell enzymes. Unfortunately, peptide agents have a number of disadva
Autor:
J. Mleczko, T.T. Nguyen, Alicja Defort, Julia Nowak-Jary, Bartlomiej Zapotoczny, Maciej Marć, Agnieszka Mironczyk, Ewelina Gronczewska, Jacek J. Kozioł, Mirosław R. Dudek
Publikováno v:
Journal of Biochemistry. 159:421-427
Distribution of the isoelectric point (pI) was calculated for the hypervariable regions of Fab fragments of the antibody molecules, which structure is annotated in the structural antibody database SabDab. The distribution is consistent with the unive
Publikováno v:
Polish Journal of Microbiology. 64:307-310
This paper presents a description of an experiment in which the survival rate of the probiotic bacteria Lactobacillus acidophilus PCM2499 was increased only due to the presence of Fe3O4 magnetic nanoparticles. The survival rate increased from 1.3 to
Publikováno v:
Physica A: Statistical Mechanics and its Applications. 392:1493-1499
In the present study, the buffering effect of magnetite nanoparticles (Fe 3 O 4 ) dispersed in an aqueous solution on the local p H value is investigated. It manifests itself in the fact that when some amount of acid or base is added to the solution