Zobrazeno 1 - 10
of 320
pro vyhledávání: '"Jacco van Rheenen"'
Autor:
E.G. Engelhardt, R.S.J.M. Schmitz, M.A. Gerritsma, C.M.T. Sondermeijer, E. Verschuur, J.H.E. Houtzager, R. Griffioen, N. Bijker, R.M. Mann, V. Retèl, F.H. van Duijnhoven, J. Wesseling, E.M.A. Bleiker, Alastair Thompson, Serena Nik-Zainal, Elinor J. Sawyer, Helen Davies, Andrew Futreal, Nicholas Navin, E. Shelley Hwang, Jos Jonkers, Jacco van Rheenen, Fariba Behbod, Esther H. Lips, Marjanka Schmidt, Lodewyk F.A. Wessels, Daniel Rea, Proteeti Bhattacharjee, Hilary Stobart, Deborah Collyar, Donna Pinto, Marja van Oirsouw, S. Alaeikhanehshir, L. Elshof
Publikováno v:
Breast, Vol 77, Iss , Pp 103764- (2024)
Background: Ductal carcinoma in situ (DCIS) can progress to invasive breast cancer (IBC), but often never will. As we cannot predict accurately which DCIS-lesions will or will not progress to IBC, almost all women with DCIS undergo breast-conserving
Externí odkaz:
https://doaj.org/article/bc84270199394f7bb7028854a77ee924
Predictive gene expression profile for adjuvant taxane benefit in breast cancer in the MATADOR trial
Autor:
Mark Opdam, Annelot G.J. van Rossum, Marlous Hoogstraat, Gergana Bounova, Hugo M. Horlings, Erik van Werkhoven, Ingrid A.M. Mandjes, A. Elise van Leeuwen – Stok, Sander Canisius, Harm van Tinteren, Alex L.T. Imholz, Johanneke E.A. Portielje, Monique E.M.M. Bos, Sandra Bakker, Jelle Wesseling, Lennart Kester, Jacco van Rheenen, Emiel J. Rutgers, Renee X. de Menezes, Lodewyk F.A. Wessels, Marleen Kok, Hendrika M. Oosterkamp, Sabine C. Linn, Marcel Soesan, Rianne M. Oosterkamp, Frank Jeurissen, Nir Weijl, Karin J. Beelen, Aart van Bochove, Gerty de Klerk, Suzan Vrijaldenhoven, Annette van der Velden, Hiltje de Graaf, Marielle Smeets, Jetske Meerum Terwogt, Jolanda Schrama, Philomeen Kuijer, Hanneke Wilmink, Ronald Hoekstra, Judith Kroep, Hans F.M. Pruijt, Leander van Gerven, Allert H. Vos, Frans Erdkamp, Willemien G. van Leeuwen-Breuk, Alexander de Graeff
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110425- (2024)
Summary: The primary objective of the prospective, randomized, multicenter, phase 3 biomarker Microarray Analysis in breast cancer to Taylor Adjuvant Drugs Or Regimens trial (MATADOR: ISRCTN61893718) is to generate a gene expression profile that can
Externí odkaz:
https://doaj.org/article/3dae747c44804a5fafa1281b33a3c21c
Autor:
Joyce Y. Buikhuisen, Patricia M. Gomez Barila, Kate Cameron, Saskia J. E. Suijkerbuijk, Cor Lieftink, Simone di Franco, Ana Krotenberg Garcia, Rebeca Uceda Castro, Kristiaan J. Lenos, Lisanne E. Nijman, Arezo Torang, Ciro Longobardi, Joan H. de Jong, Daniëlle Dekker, Giorgio Stassi, Louis Vermeulen, Roderick L. Beijersbergen, Jacco van Rheenen, Stephan Huveneers, Jan Paul Medema
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-18 (2023)
Abstract Background Colorectal cancer (CRC) can be divided into four consensus molecular subtypes (CMS), each with distinct biological features. CMS4 is associated with epithelial-mesenchymal transition and stromal infiltration (Guinney et al., Nat M
Externí odkaz:
https://doaj.org/article/f5507e6ca1b2488d88586c36a3b6eee2
Autor:
Dustin J. Flanagan, Raheleh Amirkhah, David F. Vincent, Nuray Gundaz, Pauline Gentaz, Patrizia Cammareri, Aoife J. McCooey, Amy M. B. McCorry, Natalie C. Fisher, Hayley L. Davis, Rachel A. Ridgway, Jeroen Lohuis, Joshua D. G. Leach, Rene Jackstadt, Kathryn Gilroy, Elisa Mariella, Colin Nixon, William Clark, Ann Hedley, Elke K. Markert, Douglas Strathdee, Laurent Bartholin, Keara L. Redmond, Emma M. Kerr, Daniel B. Longley, Fiona Ginty, Sanghee Cho, Helen G. Coleman, Maurice B. Loughrey, Alberto Bardelli, Timothy S. Maughan, Andrew D. Campbell, Mark Lawler, Simon J. Leedham, Simon T. Barry, Gareth J. Inman, Jacco van Rheenen, Philip D. Dunne, Owen J. Sansom
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
It remains critical to identify colorectal cancers (CRC) that will disseminate as early as possible. Here, the authors identify CRC tumours that are aggressive and prone to early dissemination, characterised by epithelial TGFβ and growth-factor sign
Externí odkaz:
https://doaj.org/article/685f337608c24440b7e084866104173a
Autor:
Miguel Vizoso, Colin E. J. Pritchard, Lorenzo Bombardelli, Bram van den Broek, Paul Krimpenfort, Roderick L. Beijersbergen, Kees Jalink, Jacco van Rheenen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Achieving spatial control of gene expression is important. Here the authors report an optimised photoactivatable Cre recombinase system, doxycycline- and light-inducible Cre recombinase (DiLiCre), and generate a DiLiCre mouse line which they use for
Externí odkaz:
https://doaj.org/article/ca99867f51bf4b11a30935fbe673b977
Autor:
Rebeca Uceda-Castro, Jessy V. van Asperen, Claire Vennin, Jacqueline A. Sluijs, Emma J. van Bodegraven, Andreia S. Margarido, Pierre A. J. Robe, Jacco van Rheenen, Elly M. Hol
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Glioma is the most common form of malignant primary brain tumours in adults. Their highly invasive nature makes the disease incurable to date, emphasizing the importance of better understanding the mechanisms driving glioma invasion. Glial f
Externí odkaz:
https://doaj.org/article/b501743dc3ad44f6bf599962b165fe6f
Autor:
Guizela Huelsz-Prince, Rutger Nico Ulbe Kok, Yvonne Goos, Lotte Bruens, Xuan Zheng, Saskia Ellenbroek, Jacco Van Rheenen, Sander Tans, Jeroen S van Zon
Publikováno v:
eLife, Vol 11 (2022)
During renewal of the intestine, cells are continuously generated by proliferation. Proliferation and differentiation must be tightly balanced, as any bias toward proliferation results in uncontrolled exponential growth. Yet, the inherently stochasti
Externí odkaz:
https://doaj.org/article/585b9959996249058c8c4dae60548621
Autor:
Li Li, Alejandro P. Ugalde, Colinda L. G. J. Scheele, Sebastian M. Dieter, Remco Nagel, Jin Ma, Abhijeet Pataskar, Gozde Korkmaz, Ran Elkon, Miao-Ping Chien, Li You, Pin-Rui Su, Onno B. Bleijerveld, Maarten Altelaar, Lyubomir Momchev, Zohar Manber, Ruiqi Han, Pieter C. van Breugel, Rui Lopes, Peter ten Dijke, Jacco van Rheenen, Reuven Agami
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-28 (2021)
Abstract Background Frequent activation of the co-transcriptional factor YAP is observed in a large number of solid tumors. Activated YAP associates with enhancer loci via TEAD4-DNA-binding protein and stimulates cancer aggressiveness. Although thous
Externí odkaz:
https://doaj.org/article/c775eb768cb945179e71e99f571ae872
Autor:
Ana Rita Lourenço, M. Guy Roukens, Danielle Seinstra, Cynthia L. Frederiks, Cornelieke E. Pals, Stephin J. Vervoort, Andreia S. Margarido, Jacco van Rheenen, Paul J. Coffer
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
In breast cancer TGF-β regulates C/EBPα and can induce epithelial-to-mesenchymal transition (EMT). Here, the authors show that C/EBPα maintains epithelial homeostasis and prevents EMT-mediated tumorigenesis.
Externí odkaz:
https://doaj.org/article/beb8ddfc0b0b4b249f1fbb7841a7699b
Autor:
Olivier G. de Jong, Daniel E. Murphy, Imre Mäger, Eduard Willms, Antonio Garcia-Guerra, Jerney J. Gitz-Francois, Juliet Lefferts, Dhanu Gupta, Sander C. Steenbeek, Jacco van Rheenen, Samir El Andaloussi, Raymond M. Schiffelers, Matthew J. A. Wood, Pieter Vader
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Extracellular vesicles (EV) facilitate intercellular transfer of biological material including RNA, but the regulatory mechanisms for their formation and transfer are incompletely known. Here the authors develop a CRISPR-based reporting system to det
Externí odkaz:
https://doaj.org/article/1db2023ed1d94f558ace5b4d70bad252