Master donor viruses A/Leningrad/134/17/57 (H2N2) and B/USSR/60/69 and derived reassortants used in live attenuated influenza vaccine (LAIV) do not display neurovirulent properties in a mouse model

Autor: Irina Kiseleva, Stephanie M. C. Basten, J. Theo M. Voeten, Sandra K. M. Drieszen-van der Cruijsen, Han van den Bosch, Larisa Rudenko, Jacco G. M. Heldens, Harrie L. Glansbeek

Publikováno v: Voeten, J T, Glansbeek, H L, Kiseleva, I V, Basten, S M, Drieszen-van der Cruijsen, S K, Rudenko, L G, van den Bosch, H & Heldens, J G 2010, ' Master donor viruses A/Leningrad/134/17/57 (H2N2) and B/USSR/60/69 and derived reassortants used in live attenuated influenza vaccine (LAIV) do not display neurovirulent properties in a mouse model ', Archives of Virology, vol. 155, no. 9, pp. 1391-1399 . https://doi.org/10.1007/s00705-010-0719-8
Archives of Virology, 155(9), 1391-1399. Springer Wien

Demonstration of the absence of neurovirulent properties of reassortant viruses contained in live attenuated influenza vaccine (LAIV) is a regulatory requirement. A mouse model was used to detect neurovirulent properties of the cold-adapted, temperat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6df3fd0405caaaf1bf1020c7de85757b
https://research.vu.nl/en/publications/d9cefe22-ca8d-470c-9955-93f8dff3bb73

Functional processing and secretion of Chikungunya virus E1 and E2 glycoproteins in insect cells

Autor: Gorben P. Pijlman, Stefan W. Metz, Paulina Andrade, Jacco G M Heldens, Just M. Vlak, Corinne Geertsema, Rob Goldbach, Monique M. van Oers, Byron E. E. Martina

Publikováno v: Virology Journal, Vol 8, Iss 1, p 353 (2011)
Virology journal, 8
Virology Journal, 8. BioMed Central Ltd.
Virology Journal
Virology journal 8 (2011)

Background Chikungunya virus (CHIKV) is a mosquito-borne, arthrogenic Alphavirus that causes large epidemics in Africa, South-East Asia and India. Recently, CHIKV has been transmitted to humans in Southern Europe by invading and now established Asian

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87169a2e8f8ac530d3254e414045ae8f
http://www.virologyj.com/content/8/1/353

Role of trimethylated chitosan (TMC) in nasal residence time, local distribution and toxicity of an intranasal influenza vaccine

Autor: Niels Hagenaars, Clemens W.G.M. Löwik, Jacco G. M. Heldens, Harrie L. Glansbeek, Han van den Bosch, Wim Jiskoot, Bram Slütter, Eric L. Kaijzel, Rob Nieuwland, Ivo Que, Enrico Mastrobattista, Pascal H.J.L.F. de Jong, Marta Mania

Publikováno v: Journal of Controlled Release, 144(1), 17-24
Journal of Controlled Release, 144(1), 17-24. Elsevier
Hagenaars, N, Mania, M, De Jong, P, Que, I, Nieuwland, R, Slütter, B, Glansbeek, H, Heldens, J, van den Bosch, H, Löwik, C, Kaijzel, E L, Mastrobattista, E & Jiskoot, W 2010, ' Role of trimethylated chitosan (TMC) in nasal residence time, local distribution and toxicity of an intranasal influenza vaccine ', Journal of Controlled Release, vol. 144, no. 1, pp. 17-24 . https://doi.org/10.1016/j.jconrel.2010.01.027

The nose is a promising immunization site and intranasal (in.) vaccination studies with whole inactivated influenza virus (WIV) adjuvanted with N,N,N-trimethylchitosan (TMC-WIV) have shown promising results. In this study, the influence of TMC on the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef7ec3d29fcc22c71e383d07c8b31d70
https://pubmed.ncbi.nlm.nih.gov/20100528