Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jac C. H. M. Wijkmans"'
Autor:
Herman D. Lim, Douglas S. Auld, Maria L. Webb, Jac C. H. M. Wijkmans, Jiuqiao Zhao, Luc Roumen, Rob Leurs, Chris de Graaf, Petra de Kruijf, Martine J. Smit, Véronique A. Renjaän, G.J.R. Zaman
Publikováno v:
Molecular Pharmacology, 80, 1108-1118. American Society for Pharmacology and Experimental Therapeutics
de Kruijf, P, Lim, H D, Roumen, L, Renjaan, V A, Zhao, J, Webb, M J, Auld, D A, Wijkmans, J C H M, Zaman, G J R, Smit, M J, de Graaf, C & Leurs, R 2011, ' Identification of a novel allosteric binding site in the CXCR2 chemokine receptor ', Molecular Pharmacology, vol. 80, pp. 1108-1118 . https://doi.org/10.1124/mol.111.073825
de Kruijf, P, Lim, H D, Roumen, L, Renjaan, V A, Zhao, J, Webb, M J, Auld, D A, Wijkmans, J C H M, Zaman, G J R, Smit, M J, de Graaf, C & Leurs, R 2011, ' Identification of a novel allosteric binding site in the CXCR2 chemokine receptor ', Molecular Pharmacology, vol. 80, pp. 1108-1118 . https://doi.org/10.1124/mol.111.073825
We have shown previously that different chemical classes of small-molecule antagonists of the human chemokine CXCR2 receptor interact with distinct binding sites of the receptor. Although an intracellular binding site for diarylurea CXCR2 antagonists
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::411a011ebb508fbe8e7aa0a7af6983a3
https://doi.org/10.1124/mol.111.073825
https://doi.org/10.1124/mol.111.073825
Autor:
Paolo Conti, Martin J. Smit, Rob Leurs, Douglas S. Auld, Petra de Kruijf, Martine J. Smit, Leontien Bosch, Miranda M. C. van der Lee, Jane van Heteren, Jac C. H. M. Wijkmans, G.J.R. Zaman, Herman D. Lim, Koc-Kan Ho, Michael Ohlmeyer
Publikováno v:
de Kruijf, P, van Heteren, J T, Lim, H D, Conti, P, van der Lee, M M, Bosch, L, Ho, K K, Auld, D S, Ohlmeyer, M, Smit, M J, Wijkmans, J C, Zaman, G J & Leurs, R 2009, ' Nonpeptidergic allosteric antagonists differentially bind to the CXCR2 chemokine receptor ', The Journal of Pharmacology and Experimental Therapeutics, vol. 329, no. 2, pp. 783-90 . https://doi.org/10.1124/jpet.108.148387
The Journal of Pharmacology and Experimental Therapeutics, 329(2), 783-90. American Society for Pharmacology and Experimental Therapeutics
The Journal of Pharmacology and Experimental Therapeutics, 329(2), 783-90. American Society for Pharmacology and Experimental Therapeutics
The chemokine receptor CXCR2 is involved in different inflammatory diseases, like chronic obstructive pulmonary disease, psoriasis, rheumatoid arthritis, and ulcerative colitis; therefore, it is considered an attractive drug target. Different classes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55b753326bf1762a0b27c10162e25857
https://doi.org/10.1124/jpet.108.148387
https://doi.org/10.1124/jpet.108.148387
Autor:
Martin-Jan Smit, Jac C. H. M. Wijkmans, Rong-Qiang Liu, Jaap van der Louw, Koc-Kan Ho, Jim Inglese, Shawn David Erickson, Ming You, Ellen Son, Andrew Laird Roughton, Douglas S. Auld, G.M.T. Vogel, Christopher M. Masterson, Paolo Conti, Daming Feng, Martijn Rooseboom, Adolph Bohnstedt, Celia Kingsbury, Maria L. Webb, Steven G. Kultgen, Yajing Rong, Michael Ohlmeyer, Philippe Samama, Wim Dokter
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:2724-2728
An imidazolylpyrimidine was identified in a CXCR2 chemokine receptor antagonist screen and was optimized for potency, in vitro metabolic stability, and oral bioavailability. It was found that subtle structural modification within the series affected
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30e77595dde5f19c6adc662437d25282
https://doi.org/10.1016/j.bmcl.2006.02.028
https://doi.org/10.1016/j.bmcl.2006.02.028
Publikováno v:
Chemokine Receptors as Drug Targets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0ec9e7a058a045709e8ac4d4da8591a
https://doi.org/10.1002/9783527631995.ch12
https://doi.org/10.1002/9783527631995.ch12
Autor:
T. M. Kruelle, Jac C. H. M. Wijkmans
Publikováno v:
ChemInform. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc76979a07b6c3ae0fd3dabd34570813
https://doi.org/10.1002/chin.200145183
https://doi.org/10.1002/chin.200145183
Autor:
Constant Adriaan Anton Van Boeckel, Michel H.M. Eppink, Martin de Kort, Stanislava Vonsovic, Maarten Honing, Wim H. A. Dokter, Martin-Jan Smit, Jac C. H. M. Wijkmans, Jeffry A. J. Wisse, Gerard M. T. Vogel, Ebo Bos, Bas Gianotten, Ellen Mattaar
Publikováno v:
ChemMedChem : chemistry enabling drug discovery 3 (2008) 8
ChemMedChem : chemistry enabling drug discovery, 3(8), 1189-1193
ChemMedChem : chemistry enabling drug discovery, 3(8), 1189-1193
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bbe01845b09e18d9b638c459ee7e2fb
https://research.wur.nl/en/publications/conjugation-of-atiii-binding-pentasaccharides-to-extend-the-half-
https://research.wur.nl/en/publications/conjugation-of-atiii-binding-pentasaccharides-to-extend-the-half-