GDF15 promotes weight loss by enhancing energy expenditure in muscle.

Autor: Wang D; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada., Townsend LK; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada., DesOrmeaux GJ; Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada., Frangos SM; Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada., Batchuluun B; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada., Dumont L; Department of Pharmacology-Physiology, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, Quebec, Canada., Kuhre RE; Global Obesity and Liver Disease Research, Global Drug Discovery, Novo Nordisk, Maaloev, Denmark.; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Ahmadi E; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada., Hu S; Key Laboratory of Geriatric Nutrition and Health, Ministry of Education, Beijing Technology and Business University, Beijing, China.; Shenzhen Key Laboratory of Metabolic Health, Center for Energy Metabolism and Reproduction, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China., Rebalka IA; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada., Gautam J; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada., Jabile MJT; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada., Pileggi CA; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada., Rehal S; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada., Desjardins EM; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada., Tsakiridis EE; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada., Lally JSV; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada., Juracic ES; Department of Kinesiology and Health Sciences, University of Waterloo, Waterloo, Ontario, Canada., Tupling AR; Department of Kinesiology and Health Sciences, University of Waterloo, Waterloo, Ontario, Canada., Gerstein HC; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada., Paré G; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada.; Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton Health Sciences, Hamilton, Ontario, Canada.; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada., Tsakiridis T; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.; Department of Oncology, McMaster University, Hamilton, Ontario, Canada., Harper ME; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada., Hawke TJ; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada., Speakman JR; Shenzhen Key Laboratory of Metabolic Health, Center for Energy Metabolism and Reproduction, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.; State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.; School of Biological Sciences, University of Aberdeen, Aberdeen, UK.; CAS Center for Excellence in Animal Evolution and Genetics (CCEAEG), Kunming, China., Blondin DP; Department of Pharmacology-Physiology, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, Quebec, Canada.; Division of Neurology, Department of Medicine, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, Quebec, Canada., Holloway GP; Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada., Jørgensen SB; Global Obesity and Liver Disease Research, Global Drug Discovery, Novo Nordisk, Maaloev, Denmark.; Bio Innovation Hub Transformational Research Unit, Novo Nordisk, Boston, MA, USA., Steinberg GR; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada. gsteinberg@mcmaster.ca.; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada. gsteinberg@mcmaster.ca.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada. gsteinberg@mcmaster.ca.

Publikováno v: Nature [Nature] 2023 Jul; Vol. 619 (7968), pp. 143-150. Date of Electronic Publication: 2023 Jun 28.