Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jabari I. Elliott"'
Publikováno v:
Viruses, Vol 7, Iss 9, Pp 4873-4893 (2015)
Poxviruses encode a broad array of proteins that serve to undermine host immune defenses. Structural analysis of four of these seemingly unrelated proteins revealed the recurrent use of a conserved beta-sandwich fold that has not been observed in any
Externí odkaz:
https://doaj.org/article/f89eccd3812848068edec449d441c10c
Autor:
Maria D. Gainey, Wayne M. Yokoyama, Liping Yang, Sytse J. Piersma, Christopher A. Nelson, John M. Errico, Xiaoli Wang, Jabari I. Elliott, Daved H. Fremont
Publikováno v:
Proceedings of the National Academy of Sciences. 116:21113-21119
Costimulation is required for optimal T cell activation, yet it is unclear whether poxviruses dedicatedly subvert costimulation during infection. Here, we report that the secreted M2 protein encoded by cowpox virus (CPXV) specifically interacts with
Autor:
Elvin J. Lauron, Maria D. Gainey, Wayne M. Yokoyama, Liping Yang, Jabari I. Elliott, Daved H. Fremont
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 14, Iss 2, p e1006883 (2018)
PLoS Pathogens, Vol 14, Iss 2, p e1006883 (2018)
Viruses have evolved mechanisms of MHCI inhibition in order to evade recognition by cytotoxic CD8+ T cells (CTLs), which is well-illustrated by our prior studies on cowpox virus (CPXV) that encodes potent MHCI inhibitors. Deletion of CPXV viral MHCI
Publikováno v:
Viruses, Vol 7, Iss 9, Pp 4873-4893 (2015)
Viruses
Viruses
Poxviruses encode a broad array of proteins that serve to undermine host immune defenses. Structural analysis of four of these seemingly unrelated proteins revealed the recurrent use of a conserved beta-sandwich fold that has not been observed in any
Autor:
Jabari I. Elliott, Xiaoli Wang, Sytse J. Piersma, Christopher A. Nelson, Wayne M. Yokoyama, Daved H. Fremont
Publikováno v:
The Journal of Immunology. 200:126.18-126.18
Poxviruses encode a broad array of proteins that serve to undermine host immune defenses. Our group has been investigating a large sequence-diverse family of secreted poxvirus proteins that appear to share a conserved beta-sandwich fold, but differ i