Fluid restrictive resuscitation with high molecular weight hyaluronan infusion in early peritonitis sepsis

Autor: Annelie Barrueta Tenhunen, Jaap van der Heijden, Paul Skorup, Marco Maccarana, Anders Larsson, Gaetano Perchiazzi, Jyrki Tenhunen

Publikováno v: Intensive Care Medicine Experimental, Vol 11, Iss 1, Pp 1-11 (2023)

Abstract Sepsis is a condition with high morbidity and mortality. Prompt recognition and initiation of treatment is essential. Despite forming an integral part of sepsis management, fluid resuscitation may also lead to volume overload, which in turn

Externí odkaz: https://doaj.org/article/bc85c4ec204c439b8fa088a144ebeadf

The antisecretory peptide AF-16 may modulate tissue edema but not inflammation in experimental peritonitis induced sepsis.

Autor: Annelie Barrueta Tenhunen, Jaap van der Heijden, Ivan Blokhin, Fabrizia Massaro, Hans Arne Hansson, Ricardo Feinstein, Anders Larsson, Jyrki Tenhunen

Publikováno v: PLoS ONE, Vol 15, Iss 8, p e0232302 (2020)

Sepsis is a life-threatening condition due to a dysregulated immunological response to infection. Apart from source control and broad-spectrum antibiotics, management is based on fluid resuscitation and vasoactive drugs. Fluid resuscitation implicate

Externí odkaz: https://doaj.org/article/c8cf850013ff478282de7d1ec8562e28

Plasma hyaluronan, hyaluronidase activity and endogenous hyaluronidase inhibition in sepsis : an experimental and clinical cohort study

Autor: Marko Sallisalmi, Michael Hultström, Paraskevi Heldin, Jaap van der Heijden, Paul Skorup, Constantinos Kolliopoulos, Jyrki Tenhunen

Publikováno v: Intensive Care Medicine Experimental, Vol 9, Iss 1, Pp 1-11 (2021)
Intensive Care Medicine Experimental

Background Plasma hyaluronan concentrations are increased during sepsis but underlying mechanisms leading to high plasma hyaluronan concentration are poorly understood. In this study we evaluate the roles of plasma hyaluronan, effective plasma hyalur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfc1ee9ea742d55c9d24307f717ca7bc
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-457912

TSSV: a tool for characterization of complex allelic variants in pure and mixed genomes

Autor: Seyed Yahya Anvar, Kristiaan J. van der Gaag, Peter de Knijff, Rolf H. A. M. Vossen, Johan T. den Dunnen, Marcel Veltrop, Henk P. J. Buermans, Jaap van der Heijden, J. Sjef Verbeek, Jeroen F.J. Laros, Cor Breukel, Rick H. de Leeuw

Publikováno v: Bioinformatics, 30(12), 1651-1659

Motivation: Advances in sequencing technologies and computational algorithms have enabled the study of genomic variants to dissect their functional consequence. Despite this unprecedented progress, current tools fail to reliably detect and characteri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::252f362c67259a1ea5da9609b56bd22d
https://doi.org/10.1093/bioinformatics/btu068

Terminal osseous dysplasia is caused by a single recurrent mutation in the FLNA gene

Autor: Jacopo Celli, Hanka Venselaar, Anna Baroncini, Martijn H. Breuning, Emmelien Aten, Lina Basel-Vanagaite, Johan T. den Dunnen, Rowida Almomani, Jaap van der Heijden, Yavuz Ariyurek, Yu Sun, Emiko Horii, Ricardo Drut, Stephen P. Robertson, Brunella Franco

Publikováno v: American Journal of Human Genetics, 87(1), 146-153
American Journal of Human Genetics, 87, 1, pp. 146-53
American Journal of Human Genetics, 87, 146-53
The American Journal of Human Genetics; Vol 87

Item does not contain fulltext Terminal osseous dysplasia (TOD) is an X-linked dominant male-lethal disease characterized by skeletal dysplasia of the limbs, pigmentary defects of the skin, and recurrent digital fibroma with onset in female infancy.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87bbfdfbd6f2e6a2c73074d7a4647f63
http://hdl.handle.net/11588/370824