Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Jaap Wilting"'
Autor:
Jaap Wilting, Frans P. Nijkamp, José Leysen, Paul W.J Van Den Wijngaard, Janneke F. Westra-De Vlieger, Andries S. Koster, Dicky van Heuven-Nolsen
Publikováno v:
European Journal of Pharmacology. 342:359-366
The bradykinin-induced rise in intracellular Ca 2+ concentration ([Ca 2+ ] i ) and the bradykinin receptor involved in this response were characterized in bovine pulmonary artery endothelial cells. It was found that bradykinin induces an intracellula
Autor:
James N. Herron, Jean M. H. van den Elsen, Louis van Bloois, Wim Jiskoot, Peter Hoogerhout, M. Antonia Busquets, Leontine M. A. van Unen, Jaap Wilting, Daan J.A. Crommelin
Publikováno v:
Biochemistry. 36:12583-12591
An antibody-peptide model system was used to study the binding characteristics between a bactericidal antibody (MN12H2) and the P1. 16 epitope of class 1 outer membrane protein PorA of Neisseria meningitidis by means of a thermodynamic approach. A se
Autor:
Jean M. H. van den Elsen, Daan J.A. Crommelin, E Boel, James N. Herron, Piet Gros, Jan Kroon, Ton Logtenberg, Jaap Wilting, Jan Poolman, Peter Hoogerhout
Publikováno v:
Proteins: Structure, Function, and Genetics. 29:113-125
Class 1 outer membrane protein PorA of Neisseria meningitidis is a vaccine candidate against bacterial meningitis. Antibodies against PorA are able to induce complement-mediated bacterial killing and thereby play an important role in protection again
Autor:
J. M. H. Van Den Elsen, Jan Poolman, James N. Herron, Jaap Wilting, Daan J.A. Crommelin, E. Van Pomeren
Publikováno v:
Analytical Biochemistry. 247:382-388
This paper describes a method for determining the affinity constant (Ka) of the binding between an antibody Fab fragment and a membrane-embedded protein epitope under equilibrium conditions. Monoclonal antibody MN12H2, directed against outer membrane
Autor:
J. M. J. Lamers, M. Krikke, E. M. Hessel, M. B. Vroom, H. J. M. G. Nelissen-Vrancken, J. H. P. Wilson, B. C. P. Hüsken, A. D. Kraneveld, A. J. Hoogstraate, B. J. A. Janssen, J. P. C. de Bruin, X. Y. Du, R.J. van der Geest, R. G. Schoemaker, M. P. J. Polak, A. E. Bottone, M.C. van den Tweel, M. J. Smit, A. Sj. Koster, A. J. M. Van Oosterhout, J. C. Visser, A. F. M. Janssen, Frans G. M. Russel, P. J. Gaillard, F. H. M. Derkx, H. Meurs, Henk Van Loveren, S. Y. Duval, Y. Muizert, T. H. Hijzen, H. E. Junginger, A. Frankhuyzen-Sierevogel, A. Nelemans, Rob Leurs, V. M. Wiegant, M. Pfaffendorf, A. M. B. Bouhuizen, E. J. J. v. Tintelen, E. H. Cox, J. F. de Vlieger, Hendrik Timmerman, Gert Folkerts, M. R. Dzoljic, Meindert Danhof, G. S. Madretsma, T. Muis, R. E. J. ten Berge, J. Stolte, A. H. Mulder, A. Yamatodani, G. Ph. Biewenga, C. G. Olymulder, H. E. Molewijk, E. de Jong, K. van der Molen, W. Vleeming, L. Groenink, H. A. A. Van Heugten, P. M. H. Schiffers, Carolina R.S. Elzinga, B. C. H. Teisman, T. Hijzen, T. A. Bruning, R. J. Vermeulen, O. H. M. Beenen, Frans P. Nijkamp, A. G. N. van Hemert, Heleen Scheerens, F. N. G. Doornekamp, H. A. J. Struyker Boudier, R. Gerth van Wijk, M. A. D. H. Schalekamp, Raymund A.C. Roos, Jaap Wilting, B. H. R. Wolffenbuttel, J. Smit, A. den Hertog, J. Oosting, N. L. U. van Meeteren, F. J. Blomjous, Edwin E. Zvartau, H. B. van Wezel, Jan M. van Ree, F. Hogenboom, J.H.J. Copius Peereboom-Stegeman, J. J. de Bie, Gudarz Sadeghi Hashjin, F. J. Zijlstra, A. C. Wouterse, P. D. Verdouw, M. Schuiling, C. J. J. Avezaat, F. R. L. Crijns, J. A. Bouwknecht, Mahnaz Shirmohammadi, D. van Heuven-Nolsen, L. M. Broersen, J. H. Brakkee, E. Bos, A. Bast, F. Nijkamp, P. G. M. Bloemen, A. J. Nicastia, Pramod R. Saxena, G. Hofman, C. Borst, S. L. T. Cappendijk, J. L. Slangen, P. M. Verdouw, E. A. Dubois, J. M. Van Oosterhout, A. N. M. Schoffelmeer, J. P. Van Kats, C. M. Kasbergen, R. Masereeuw, P. A. Van Zwieten, Robert P. Coppes, H. A. J. Struijker Boudier, A. Maas, P. Voorn, Douwe D. Breimer, M. J. A. P. Daemen, Willem A. Bax, Ferdi Engels, K. L. Kam, F. P. Jansen, T. L. Buckley, W. B. Stam, A. G. De Boer, R. de Vries, Willem Hendrik Gispen, R. J. E. Joordens, G. H. K. Tjon, H. Van Loveren, E. Velema, D. L. Brouwers, G. R. M. M. Haenen, A. M. van der Poel, D.J. de Wildt, A. Pijpers, P. R. Saxena, L. M. A. Sassen, J. Gommans, J. Peter, T. Mochizuki, J. Zhang, J. L. de Boer, Mirjam A.F.M. Gerrits, H. van de Meent, Frans P. Niikamp, L. M. de Lannoy, Alexander H. J. Danser, C. van den Berg, F. P. Nijkamp, W. H. Gispen, Jos F.M. Smits, J. P. M. Dam, T. van Laar, H. Burbach, E. A. J. Kalkman, Johan Zaagsma, A. H. J. Herremans, J. Mos, Af Roffel, W. M. Moons, Theresa L. Buckley, H. E. Boddé, P. Nestby, G. Wardeh, E. A. Winkler Prins, P.F. van Bergen, J. Wemer, P. C. J. J. Passier, C. M. A. M. van der Horst, C. M. Mohede, M. J. Post, E. A. Van Royen, J. C. Compaan, P.W.J. van den Wijngaard, P. C. Chang, J. Zwavelina, A. R. Cools, R. E. Santing, M. A. Gingras, F. P. Niikamp, M. J. B. Kemme, H. van Essen, M. J. A. Verluyten, M. J. Van De Velde, R. A. Maes, B. Olivier, M. Y. Bilgin, Paul A.J. Henricks, I. M. Garrelds, A. P. M. van Dijk, D. Visser, M. Koopal, H. Drexler, J. H. M. Verheijden, J. Zwaveling, H. Sipma, B. H. Hoiting, C. A. M. Van Kesteren, J. van der Gugten, R. P. W. Heinsbroek, B. C. G. Gho, C. de Graaf-in't Veld, P. A. J. Henricks, E. J. F. Timmenga, Nadezda Patkina, J. Verhoef, A. H. G. J. Schrijvers, D. H. G. Versteeg, L.A.M.G. van Leengoed, N. Michiels, E.M. van der Aa, Roger A.H. Adan
Publikováno v:
Pharmacy World & Science. 16:J3-J19
Autor:
Marcel J.E. Fischer, Jaap Wilting, Fred R. Opperdoes, Isabelle Coppens, Eugene L.M. Vansterkenburg, Lambert H.M. Janssen, Octaaf J.M. Bos
Publikováno v:
Acta Tropica. 54:237-250
In plasma, a significant part of suramin circulates in tight association with low-density lipoproteins (LDL). At therapeutically obtainable concentrations (100 microM) of suramin, about 85% of the total amount of the drug was bound to proteins, appro
Autor:
Jaap Wilting, RenéF. van der Linden, Lambert H.M. Janssen, Octaaf J.M. Bos, Marcel J.E. Fischer
Publikováno v:
Biochemical Pharmacology. 45:2411-2416
The binding properties of the steroids testosterone and pregnenolone to human serum albumin (HSA) and derived fragments of albumin have been investigated by means of equilibrium dialysis and circular dichroism. The 46 kDa peptic fragment (P46) of HSA
Autor:
Marcel J.E. Fischer, Rene F. van der Linden, Lambert H.M. Janssen, Roel Melsert, Octaaf J.M. Bos, Jos W. Hoogerbrugge, Jaap Wilting, Focko F. G. Rommerts
Publikováno v:
Molecular and Cellular Endocrinology. 82:23-32
__Abstract__ The effects of purified albumin species and albumin fragments (0.2–1% w/v) on short-term (4 h) steroid secretion by immature rat Leydig cells, in the presence of a maximally stimulating dose of luteinizing hormone (LH), were investigat
Autor:
Marcel R. Linschoten, Lambert H.M. Janssen, Joop H. van Lenthe, Jaap Wilting, Sjef J. De Kimpe, Gert W. Klein Kranenbarg
Publikováno v:
Journal of Molecular Structure. 237:339-354
Recent experimental evidence indicates that the side chain carboxylate group of an aspartic acid residue located at position 113 (Asp i13) in the pharmacologically important /I-adrenergic receptor protein is directly involved in the binding of P-adre
Autor:
Jan Paul C.I. Boon, Jaap Wilting, Octaaf J.M. Bos, Lambert H.M. Janssen, Marcel J.E. Fischer, Eugene L.M. Vansterkenburg
Publikováno v:
Biochemical pharmacology. 40(7)
The objective of the present study was to investigate the location of the high-affinity suramin binding sites on the human serum albumin molecule. For this purpose, circular dichroism and equilibrium dialysis experiments were performed on the interac