Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Jaap Lemmers"'
Discovery of Targets for Immune–Metabolic Antitumor Drugs Identifies Estrogen-Related Receptor Alpha
Autor:
Avinash Sahu, Xiaoman Wang, Phillip Munson, Jan P.G. Klomp, Xiaoqing Wang, Shengqing Stan Gu, Ya Han, Gege Qian, Phillip Nicol, Zexian Zeng, Chenfei Wang, Collin Tokheim, Wubing Zhang, Jingxin Fu, Jin Wang, Nishanth Ulhas Nair, Joost A.P. Rens, Meriem Bourajjaj, Bas Jansen, Inge Leenders, Jaap Lemmers, Mark Musters, Sanne van Zanten, Laura van Zelst, Jenny Worthington, Jun S. Liu, Dejan Juric, Clifford A. Meyer, Arthur Oubrie, X. Shirley Liu, David E. Fisher, Keith T. Flaherty
Publikováno v:
Cancer Discovery. 13:672-701
Drugs that kill tumors through multiple mechanisms have the potential for broad clinical benefits. Here, we first developed an in silico multiomics approach (BipotentR) to find cancer cell–specific regulators that simultaneously modulate tumor immu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b05f0a1073019f8585bd588983e60c2c
https://doi.org/10.1158/2159-8290.cd-22-0244
https://doi.org/10.1158/2159-8290.cd-22-0244
Autor:
Keith T. Flaherty, David E. Fisher, X. Shirley Liu, Arthur Oubrie, Clifford A. Meyer, Dejan Juric, Jun S. Liu, Jenny Worthington, Laura van Zelst, Sanne van Zanten, Mark Musters, Jaap Lemmers, Inge Leenders, Bas Jansen, Meriem Bourajjaj, Joost A.P. Rens, Nishanth Ulhas Nair, Jin Wang, Jingxin Fu, Wubing Zhang, Collin Tokheim, Chenfei Wang, Zexian Zeng, Phillip Nicol, Gege Qian, Ya Han, Shengqing Stan Gu, Xiaoqing Wang, Jan P.G. Klomp, Phillip Munson, Xiaoman Wang, Avinash Sahu
Machine learning evaluation of immune-metabolic targets in predicting patient response to anti-PD1 and anti-CTLA4 combination therapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f8bd2ff895e83091c44926de41c53a8
https://doi.org/10.1158/2159-8290.22543017
https://doi.org/10.1158/2159-8290.22543017
Autor:
Keith T. Flaherty, David E. Fisher, X. Shirley Liu, Arthur Oubrie, Clifford A. Meyer, Dejan Juric, Jun S. Liu, Jenny Worthington, Laura van Zelst, Sanne van Zanten, Mark Musters, Jaap Lemmers, Inge Leenders, Bas Jansen, Meriem Bourajjaj, Joost A.P. Rens, Nishanth Ulhas Nair, Jin Wang, Jingxin Fu, Wubing Zhang, Collin Tokheim, Chenfei Wang, Zexian Zeng, Phillip Nicol, Gege Qian, Ya Han, Shengqing Stan Gu, Xiaoqing Wang, Jan P.G. Klomp, Phillip Munson, Xiaoman Wang, Avinash Sahu
Validation of bipotent regulators of angiogenesis or growth-suppressor.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b7d32c02bc8a4f361cca2ae148f410
https://doi.org/10.1158/2159-8290.22543002
https://doi.org/10.1158/2159-8290.22543002
Autor:
Keith T. Flaherty, David E. Fisher, X. Shirley Liu, Arthur Oubrie, Clifford A. Meyer, Dejan Juric, Jun S. Liu, Jenny Worthington, Laura van Zelst, Sanne van Zanten, Mark Musters, Jaap Lemmers, Inge Leenders, Bas Jansen, Meriem Bourajjaj, Joost A.P. Rens, Nishanth Ulhas Nair, Jin Wang, Jingxin Fu, Wubing Zhang, Collin Tokheim, Chenfei Wang, Zexian Zeng, Phillip Nicol, Gege Qian, Ya Han, Shengqing Stan Gu, Xiaoqing Wang, Jan P.G. Klomp, Phillip Munson, Xiaoman Wang, Avinash Sahu
Evaluation of bulk-BipotentR (BipotentR without single-cell sub-module).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43feedacd6b18e42f20eb83f3da7e0da
https://doi.org/10.1158/2159-8290.22543008
https://doi.org/10.1158/2159-8290.22543008
Autor:
Keith T. Flaherty, David E. Fisher, X. Shirley Liu, Arthur Oubrie, Clifford A. Meyer, Dejan Juric, Jun S. Liu, Jenny Worthington, Laura van Zelst, Sanne van Zanten, Mark Musters, Jaap Lemmers, Inge Leenders, Bas Jansen, Meriem Bourajjaj, Joost A.P. Rens, Nishanth Ulhas Nair, Jin Wang, Jingxin Fu, Wubing Zhang, Collin Tokheim, Chenfei Wang, Zexian Zeng, Phillip Nicol, Gege Qian, Ya Han, Shengqing Stan Gu, Xiaoqing Wang, Jan P.G. Klomp, Phillip Munson, Xiaoman Wang, Avinash Sahu
Energy metabolism and immune signaling by targeting ESRRA in vitro.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39b182d5b747b353147cb36f31e0f627
https://doi.org/10.1158/2159-8290.22542975
https://doi.org/10.1158/2159-8290.22542975
Autor:
Keith T. Flaherty, David E. Fisher, X. Shirley Liu, Arthur Oubrie, Clifford A. Meyer, Dejan Juric, Jun S. Liu, Jenny Worthington, Laura van Zelst, Sanne van Zanten, Mark Musters, Jaap Lemmers, Inge Leenders, Bas Jansen, Meriem Bourajjaj, Joost A.P. Rens, Nishanth Ulhas Nair, Jin Wang, Jingxin Fu, Wubing Zhang, Collin Tokheim, Chenfei Wang, Zexian Zeng, Phillip Nicol, Gege Qian, Ya Han, Shengqing Stan Gu, Xiaoqing Wang, Jan P.G. Klomp, Phillip Munson, Xiaoman Wang, Avinash Sahu
ESRRA inhibition is associated with immune infiltrations and proinflammatory signaling in patient tumors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14b140d40f3b28687b611d593f97aa22
https://doi.org/10.1158/2159-8290.22542987
https://doi.org/10.1158/2159-8290.22542987
Autor:
Keith T. Flaherty, David E. Fisher, X. Shirley Liu, Arthur Oubrie, Clifford A. Meyer, Dejan Juric, Jun S. Liu, Jenny Worthington, Laura van Zelst, Sanne van Zanten, Mark Musters, Jaap Lemmers, Inge Leenders, Bas Jansen, Meriem Bourajjaj, Joost A.P. Rens, Nishanth Ulhas Nair, Jin Wang, Jingxin Fu, Wubing Zhang, Collin Tokheim, Chenfei Wang, Zexian Zeng, Phillip Nicol, Gege Qian, Ya Han, Shengqing Stan Gu, Xiaoqing Wang, Jan P.G. Klomp, Phillip Munson, Xiaoman Wang, Avinash Sahu
ESRRA inhibition induces antitumor immunity in vivo.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f6732f8454ea4493faf3849158646cc
https://doi.org/10.1158/2159-8290.22542990.v1
https://doi.org/10.1158/2159-8290.22542990.v1
Autor:
Keith T. Flaherty, David E. Fisher, X. Shirley Liu, Arthur Oubrie, Clifford A. Meyer, Dejan Juric, Jun S. Liu, Jenny Worthington, Laura van Zelst, Sanne van Zanten, Mark Musters, Jaap Lemmers, Inge Leenders, Bas Jansen, Meriem Bourajjaj, Joost A.P. Rens, Nishanth Ulhas Nair, Jin Wang, Jingxin Fu, Wubing Zhang, Collin Tokheim, Chenfei Wang, Zexian Zeng, Phillip Nicol, Gege Qian, Ya Han, Shengqing Stan Gu, Xiaoqing Wang, Jan P.G. Klomp, Phillip Munson, Xiaoman Wang, Avinash Sahu
Drugs that kill tumors through multiple mechanisms have the potential for broad clinical benefits. Here, we first developed an in silico multiomics approach (BipotentR) to find cancer cell–specific regulators that simultaneously modulate tumor immu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84488520c99a3a21d3b5183ab7ba888e
https://doi.org/10.1158/2159-8290.c.6550104.v1
https://doi.org/10.1158/2159-8290.c.6550104.v1
Autor:
Keith T. Flaherty, David E. Fisher, X. Shirley Liu, Arthur Oubrie, Clifford A. Meyer, Dejan Juric, Jun S. Liu, Jenny Worthington, Laura van Zelst, Sanne van Zanten, Mark Musters, Jaap Lemmers, Inge Leenders, Bas Jansen, Meriem Bourajjaj, Joost A.P. Rens, Nishanth Ulhas Nair, Jin Wang, Jingxin Fu, Wubing Zhang, Collin Tokheim, Chenfei Wang, Zexian Zeng, Phillip Nicol, Gege Qian, Ya Han, Shengqing Stan Gu, Xiaoqing Wang, Jan P.G. Klomp, Phillip Munson, Xiaoman Wang, Avinash Sahu
Overall design.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8a20eea33c39b0402584a83f5507291
https://doi.org/10.1158/2159-8290.22542999
https://doi.org/10.1158/2159-8290.22542999
Autor:
Keith T. Flaherty, David E. Fisher, X. Shirley Liu, Arthur Oubrie, Clifford A. Meyer, Dejan Juric, Jun S. Liu, Jenny Worthington, Laura van Zelst, Sanne van Zanten, Mark Musters, Jaap Lemmers, Inge Leenders, Bas Jansen, Meriem Bourajjaj, Joost A.P. Rens, Nishanth Ulhas Nair, Jin Wang, Jingxin Fu, Wubing Zhang, Collin Tokheim, Chenfei Wang, Zexian Zeng, Phillip Nicol, Gege Qian, Ya Han, Shengqing Stan Gu, Xiaoqing Wang, Jan P.G. Klomp, Phillip Munson, Xiaoman Wang, Avinash Sahu
Kaplan–Meier plots showing progression-free survival and overall survival differences for patients receiving anti-PD1 between the low-risk and high-risk groups defined by the median value of deepBTAS.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41c036ca17a02f0a9ee87942ca3c2afd
https://doi.org/10.1158/2159-8290.22543011.v1
https://doi.org/10.1158/2159-8290.22543011.v1