Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jaap J.M. Smit"'
Autor:
Ben Roelofsen, Johanna L.P.M. Timmermans-Hereijgers, Piet Borst, Wim J. van Blitterswijk, Alexander J. Smith, Alfred H. Schinkel, Karel W. A. Wirtz, Jaap J.M. Smit
Publikováno v:
FEBS Letters. 354:263-266
The mouse mdr2 P-glycoprotein (P-gp) and its human MDR3 homologue are present in high concentrations in the canalicular membrane of hepatocytes. Mice lacking this protein are unable to secrete phosphatidylcholine (PC) into bile, suggesting that this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::980df31e3dc4f88c108e38e8ad15df99
https://doi.org/10.1016/0014-5793(94)01135-4
https://doi.org/10.1016/0014-5793(94)01135-4
Publikováno v:
Journal of Biological Chemistry. 266:5303-5310
Two genes, MDR1 and MDR3, constitute the human P-glycoprotein gene family. To examine the evolutionary relationship between the three known classes of mammalian P-glycoprotein genes, we have cloned the MDR3 gene and compared its structure with that o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edb75fb2177d7ffc0daaeb1d977da1c5
https://doi.org/10.1016/s0021-9258(19)67788-4
https://doi.org/10.1016/s0021-9258(19)67788-4
Regulation of protein secretion into bile: studies in mice with a disrupted mdr2 p-glycoprotein gene
Autor:
Jaap J.M. Smit, Michel J.A. van Wijland, Wilma M. Frederiks, Ronald P.J. Oude Elferink, Albert K. Groen, Alfred H. Schinkel
Publikováno v:
Gastroenterology, 109(6), 1997-2006. W.B. Saunders Ltd
Background & Aims: Protein is secreted into bile via several independent pathways. The aim of this study was to investigate whether these pathways are influenced by secretion of biliary lipid. Methods: Protein secretion and biliary lipid output were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::185c5023c15e7b77f836f3d8487a3a0f
https://pure.amc.nl/en/publications/regulation-of-protein-secretion-into-bile-studies-in-mice-with-a-disrupted-mdr2-pglycoprotein-gene(5b8c7a31-3807-4832-a6de-833c2061eac0).html
https://pure.amc.nl/en/publications/regulation-of-protein-secretion-into-bile-studies-in-mice-with-a-disrupted-mdr2-pglycoprotein-gene(5b8c7a31-3807-4832-a6de-833c2061eac0).html
Publikováno v:
Adenine Nucleotides in Cellular Energy Transfer and Signal Transduction ISBN: 9783034873178
Overexpression of P-glycoprotein genes is one established cause of multidrug resistance in mammalian cells. We are studying P-glycoproteins and their genes in man, in the mouse and in the nematode worm Caenorhabditis elegans in order to understand th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e8fcd85c87423f21ec8211fa1526ff7
https://doi.org/10.1007/978-3-0348-7315-4_35
https://doi.org/10.1007/978-3-0348-7315-4_35
Autor:
Schinkel, Alfred H., Borst, Piet, Smit, Jaap J. M., Wagenaar, Els, Dollé, Martijn, Arceci, Robert J., Baas, Frank, Tsuruo, Takashi, Mechetner, Eugene B., Roninson, Igor B.
Publikováno v:
International Journal of Cancer; Sep1993, Vol. 55 Issue 3, p478-484, 7p
Publikováno v:
Journal of Cellular Biochemistry; Feb1994 Supplement 18D, Vol. 56, p97-116, 20p
Publikováno v:
Gut; May1994 Supp, Vol. 35 Issue 5, pS1-S28, 1p, 34 Charts, 1 Graph