Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jaap F. Rodrigues de Miranda"'
Autor:
Yvonne J.B. Van Megen, W. Matthijs Blankesteijn, Jaap F. Rodrigues de Miranda, Helene L.M. Siero, Frans G. M. Russel
Publikováno v:
European Journal of Pharmacology: Molecular Pharmacology. 244:21-27
Muscarinic receptors in mammalian kidney seem to be involved in diuresis. In this study we give a detailed characterization of receptors in rat kidney. Specific binding of [3H](-)-quinuclidinylbenzilate ([3H]QNB) to membranes of rat kidney cortex was
Autor:
Marc A. G. J. ten Dam, Joeke Reyenga, Lambertus J.H. van Tits, Herman T. Droste, S. J. Graafsma, Hub Wollersheim, Jaap F. Rodrigues de Miranda, Theo Thien
Publikováno v:
Clinical Science. 80:325-331
1. α2-Adrenoceptors on platelet membranes and β2-adrenoceptors on lymphocytes were studied in 24 patients with primary Raynaud's phenomenon and in 24 age- and sex-matched control subjects. In two subgroups, a standardized mental arithmetic test and
Autor:
Reinhold Tacke, Roland Feifel, Jaap F. Rodrigues de Miranda, Carsten Strohmann, Arne J. Aasen, Ernst Mutschler, Günter Lambrecht
Publikováno v:
European Journal of Pharmacology. 195:115-123
A method was developed to determine the affinities of antimuscarinic drugs at m 1 receptors. [ 3 H](±)-Telenzepine served as radioligand in crude preparations of calf superior cervical ganglia and showed high affinity for a single receptor populatio
Autor:
Bob Th.R. Wentges, A. B. M. Klaassen, Cees A.M. van Ginneken, Yvonne J.B. Van Megen, Jaap F. Rodrigues de Miranda
Publikováno v:
Journal of Allergy and Clinical Immunology. 87:530-540
Nasal hyperreactivity in nasal allergy may be due to changes of the characteristics in adrenergic receptors. Radioligand receptor-binding studies with the antagonists, 3H-prazosin (alpha 1-adrenoceptor), 3H-rauwolscine (alpha 2-adrenoceptor), and 125
Autor:
Cees A.M. van Ginneken, Yvonne J.B. Van Megen, Jaap F. Rodrigues de Miranda, Bob Th.R. Wentges, André B. M. Klaassen
Publikováno v:
European Journal of Pharmacology. 182:561-567
The specific binding of [3H]rauwolscine to rat nasal mucosa membranes was saturable, stereoselective and of high affinity. The Scatchard plot pointed to a homogeneous population of binding sites (Kd = 3.6 +/- 0.6 nM; Bmax = 5.1 +/- 0.7 pmol/g). The n
Autor:
Jaap F. Rodrigues de Miranda, Cees A.M. van Ginneken, Yvonne J.B. Van Megen, Bob Th.R. Wentges, Corke J.B.M. Van Ratingen, A. B. M. Klaassen
Publikováno v:
European Journal of Pharmacology. 182:515-525
The specific binding of 125I-(-)-cyanopindolol (125I-(-)-CYP) to homogenates and cryostat sections of rat nasal mucosa was saturable, stereoselective and of high affinity (Kd = 5.0 +/- 0.4 pM. Bmax = 204 +/- 12 fmol/mg protein and Kd = 7.2 +/- 0.7 pM
Prejunctional muscarinic receptors on cholinergic nerves in guinea pig airways are of the M2 subtype
Autor:
Jaap F. Rodrigues de Miranda, Cees J.A. Doelman, R. Corrine Sprong, Aalt Bast, J. Elsbeth Nagtegaal
Publikováno v:
European Journal of Pharmacology. 193:117-119
Prejunctional inhibitory muscarinic receptors in guinea pig tracheal strips were investigated by electrical field stimulation. Pilocarpine and methacholine caused, in a similar way, a dose-dependent increase in baseline with a concomittant decrease i
Autor:
Jan Pieter C. Zwart, Clementina M. van Rijn, R. Dirksen, Jaap F. Rodrigues de Miranda, Elly Willems-van Bree
Publikováno v:
European journal of pharmacology. 371(2-3)
Within the context of the discussion about rational polytherapy, we determined the effects of four anaesthetics on the binding of [3H]t-butylbicycloorthobenzoate ([3H]TBOB) to the GABA(A) receptor complex in the presence of several concentrations of
Publikováno v:
Epilepsy research. 12(2)
[ 3 H]-t- Butylbicycloorthobenzoate ([ 3 H]TBOB) , a convulsant, is known to label a binding site on the GABAA receptor complex. Bicuculline methochloride (bicuculline MCl), folic acid, pentazocine, naloxone, ethyl-β-carboline-3-carboxylate (βCCE)
Publikováno v:
Life Sciences. 41:2023-2032
The receptor occupancy-biological effect relationship for muscarinic receptors in guinea pig ileal smooth muscle has been studied by comparison of radioligand binding and contractile response. Muscarinic receptors in homogenates of ileal smooth muscl