Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Jaap D van Buul"'
Publikováno v:
Vascular Biology, Vol 5, Iss 1, Pp 1-13 (2023)
Intercellular adhesion molecules (ICAMs) are cell surface proteins that play a crucial role in the body’s immune response and inflammatory processes. ICAM1 and ICAM2 are two ICAM family members expressed on the surface of various cell types, includ
Externí odkaz:
https://doaj.org/article/4f15ddf2758745e1b658499b089f0162
Autor:
Eike K Mahlandt, Sebastián Palacios Martínez, Janine JG Arts, Simon Tol, Jaap D van Buul, Joachim Goedhart
Publikováno v:
eLife, Vol 12 (2023)
The inner layer of blood vessels consists of endothelial cells, which form the physical barrier between blood and tissue. This vascular barrier is tightly regulated and is defined by cell-cell contacts through adherens and tight junctions. To investi
Externí odkaz:
https://doaj.org/article/6f771142eee24d0bb49875f225b5d7e6
Autor:
Wessel S Rodenburg, Jaap D van Buul
Publikováno v:
Vascular Biology, Vol 3, Iss 1, Pp R77-R95 (2021)
Rho GTPases are small signalling G-proteins that are central regulators of cytoskeleton dynamics, and thereby regulate many cellular processes, including the shape, adhesion and migration of cells. As such, Rho GTPases are also essential for the inva
Externí odkaz:
https://doaj.org/article/d6dd3956e96e43f4a57b4f5382d27e3f
Autor:
Janine JG Arts, Eike K Mahlandt, Max LB Grönloh, Lilian Schimmel, Ivar Noordstra, Emma Gordon, Abraham CI van Steen, Simon Tol, Barbara Walzog, Jos van Rijssel, Martijn A Nolte, Marten Postma, Satya Khuon, John M Heddleston, Eric Wait, Teng Leong Chew, Mark Winter, Eloi Montanez, Joachim Goedhart, Jaap D van Buul
Publikováno v:
eLife, Vol 10 (2021)
Upon inflammation, leukocytes rapidly transmigrate across the endothelium to enter the inflamed tissue. Evidence accumulates that leukocytes use preferred exit sites, alhough it is not yet clear how these hotspots in the endothelium are defined and h
Externí odkaz:
https://doaj.org/article/e8c403c2145749c68b603d43a3547e87
Plasminogen Activator Inhibitor-1 Controls Vascular Integrity by Regulating VE-Cadherin Trafficking.
Autor:
Anna E Daniel, Ilse Timmerman, Igor Kovacevic, Peter L Hordijk, Luc Adriaanse, Ilkka Paatero, Heinz-Georg Belting, Jaap D van Buul
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145684 (2015)
BACKGROUND:Plasminogen activator inhibitor-1 (PAI-1), a serine protease inhibitor, is expressed and secreted by endothelial cells. Patients with PAI-1 deficiency show a mild to moderate bleeding diathesis, which has been exclusively ascribed to the f
Externí odkaz:
https://doaj.org/article/216959ef292b4c74a663ef51be4fc8ae
Autor:
Kathinka W E M van Hooren, Léon J A Spijkers, Dorothee van Breevoort, Mar Fernandez-Borja, Ruben Bierings, Jaap D van Buul, Astrid E Alewijnse, Stephan L M Peters, Jan Voorberg
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91346 (2014)
Sphingosine-1-phosphate (S1P) is an agonist for five distinct G-protein coupled receptors, that is released by platelets, mast cells, erythrocytes and endothelial cells. S1P promotes endothelial cell barrier function and induces release of endothelia
Externí odkaz:
https://doaj.org/article/ecb94040bd484e56aacf2e23ee062e9c
Autor:
Thomas Samson, Jaap D van Buul, Jeffrey Kroon, Christopher Welch, Erik N Bakker, Hanke L Matlung, Timo K van den Berg, Lisa Sharek, Claire Doerschuk, Klaus Hahn, Keith Burridge
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e55202 (2013)
The passage of leukocytes across the endothelium and into arterial walls is a critical step in the development of atherosclerosis. Previously, we showed in vitro that the RhoG guanine nucleotide exchange factor SGEF (Arhgef26) contributes to the form
Externí odkaz:
https://doaj.org/article/eb89857598e3497b92aa0d0e48b504bd
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29912 (2012)
The guanine-nucleotide exchange factor Trio encodes two DH-PH domains that catalyze nucleotide exchange on Rac1, RhoG and RhoA. The N-terminal DH-PH domain is known to activate Rac1 and RhoG, whereas the C-terminal DH-PH domain can activate RhoA. The
Externí odkaz:
https://doaj.org/article/3ae272e44afc4683861c4904208a2605
Autor:
Jaap D van Buul, Jos van Rijssel, Floris P J van Alphen, Mark Hoogenboezem, Simon Tol, Kees A Hoeben, Jan van Marle, Erik P J Mul, Peter L Hordijk
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e11336 (2010)
BackgroundDuring transendothelial migration, leukocytes use adhesion molecules, such as ICAM-1, to adhere to the endothelium. ICAM-1 is a dynamic molecule that is localized in the apical membrane of the endothelium and clusters upon binding to leukoc
Externí odkaz:
https://doaj.org/article/7193af2812dc4e36a4aa181fd4b28836
Autor:
Eike K. Mahlandt, Sebastián Palacios Martínez, Janine J. G. Arts, Simon Tol, Jaap D. van Buul, Joachim Goedhart
The inner layer of blood vessels consists of endothelial cells, which form the physical barrier between blood and tissue. This vascular barrier is tightly regulated to allow the passage of essential molecules like oxygen, carbon-dioxide, water, ions,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7daa703b53329f0defe16f2c5f4ff69f
https://doi.org/10.7554/elife.84364.1
https://doi.org/10.7554/elife.84364.1
