Zobrazeno 1 - 10
of 219
pro vyhledávání: '"Jaap D, van Buul"'
Apelin modulates inflammation and leukocyte recruitment in experimental autoimmune encephalomyelitis
Autor:
Hongryeol Park, Jian Song, Hyun-Woo Jeong, Max L. B. Grönloh, Bong Ihn Koh, Esther Bovay, Kee-Pyo Kim, Luisa Klotz, Patricia A. Thistlethwaite, Jaap D. van Buul, Lydia Sorokin, Ralf H. Adams
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Demyelination due to autoreactive T cells and inflammation in the central nervous system are principal features of multiple sclerosis (MS), a chronic and highly disabling human disease affecting brain and spinal cord. Here, we show that trea
Externí odkaz:
https://doaj.org/article/73b6422aec3343758220e17b6a05df69
Autor:
Daan P. van den Brink, Derek J. B. Kleinveld, Annabel Bongers, Jaël Vos, Joris J. T. H. Roelofs, Nina C. Weber, Jaap D. van Buul, Nicole P. Juffermans
Publikováno v:
Intensive Care Medicine Experimental, Vol 11, Iss 1, Pp 1-9 (2023)
Abstract Background Endothelial injury and permeability are a hallmark of sepsis. Initial resuscitation of septic patients with crystalloids is associated with aggravation of endothelial permeability, which may be related either to low protein conten
Externí odkaz:
https://doaj.org/article/2e71c8bb73db4b7498d7cd7a174e6bfb
Publikováno v:
Vascular Biology, Vol 5, Iss 1, Pp 1-13 (2023)
Intercellular adhesion molecules (ICAMs) are cell surface proteins that play a crucial role in the body’s immune response and inflammatory processes. ICAM1 and ICAM2 are two ICAM family members expressed on the surface of various cell types, includ
Externí odkaz:
https://doaj.org/article/4f15ddf2758745e1b658499b089f0162
Autor:
Eike K Mahlandt, Sebastián Palacios Martínez, Janine JG Arts, Simon Tol, Jaap D van Buul, Joachim Goedhart
Publikováno v:
eLife, Vol 12 (2023)
The inner layer of blood vessels consists of endothelial cells, which form the physical barrier between blood and tissue. This vascular barrier is tightly regulated and is defined by cell-cell contacts through adherens and tight junctions. To investi
Externí odkaz:
https://doaj.org/article/6f771142eee24d0bb49875f225b5d7e6
Autor:
Robert B. Klanderman, Joachim J. Bosboom, Denise P. Veelo, Joris J. T. H. Roelofs, Dirk de Korte, Robin van Bruggen, Liffert Vogt, Jaap D. van Buul, Markus W. Hollmann, Margreeth B. Vroom, Nicole P. Juffermans, Bart F. Geerts, Alexander P. J. Vlaar
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Transfusion-associated circulatory overload (TACO) is the leading cause of transfusion related morbidity and mortality. The only treatment is empirical use of furosemide. Our aim was to investigate if furosemide can prevent TACO. A randomize
Externí odkaz:
https://doaj.org/article/476d1c299fa947349cdd2af40e6cbc90
Autor:
Franka H. van der Linden, Eike K. Mahlandt, Janine J. G. Arts, Joep Beumer, Jens Puschhof, Saskia M. A. de Man, Anna O. Chertkova, Bas Ponsioen, Hans Clevers, Jaap D. van Buul, Marten Postma, Theodorus W. J. Gadella, Joachim Goedhart
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Currently, genetically encoded calcium indicators are not suitable for direct quantification. Here the authors engineer a fluorescence lifetime imaging calcium biosensor, Turquoise Calcium Fluorescence LIfeTime Sensor (Tq-Ca-FLITS), and measure intra
Externí odkaz:
https://doaj.org/article/28e02e090b82435fa3bc07ed281bc827
Autor:
Rouven Schoppmeyer, Jaap D. van Buul
Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101509- (2022)
Summary: This protocol presents an assay for transmigration analysis of human cytotoxic T cells (CTL) under physiological flow in vitro. We describe detailed analysis steps of human CTL behavior, from adhesion to diapedesis, using live cell imaging w
Externí odkaz:
https://doaj.org/article/a5b8bc0a0b5a402fb4b636812b3a3ec3
Autor:
Kim C. M. Jeucken, Charlotte C. N. van Rooijen, Yik Y. Kan, Lotte A. Kocken, Aldo Jongejan, Abraham C. I. van Steen, Jaap D. van Buul, Henric K. Olsson, Jan Piet van Hamburg, Sander W. Tas
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Endothelial cells (ECs) are important contributors to inflammation in immune-mediated inflammatory diseases (IMIDs). In this study, we examined whether CD4+ memory T (Tm) cells can drive EC inflammatory responses. Human Tm cells produced ligands that
Externí odkaz:
https://doaj.org/article/611aa83d146b4cf1828eb31ebc7b2cf4
Autor:
Alina Klems, Jos van Rijssel, Anne S. Ramms, Raphael Wild, Julia Hammer, Melanie Merkel, Laura Derenbach, Laetitia Préau, Rabea Hinkel, Irina Suarez-Martinez, Stefan Schulte-Merker, Ramon Vidal, Sascha Sauer, Riikka Kivelä, Kari Alitalo, Christian Kupatt, Jaap D. van Buul, Ferdinand le Noble
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Arterial flow regulates artery diameter but other mechanisms may also affect this. Here, the authors show that the guanine nucleotide exchange factor Trio and GTPases Rac1 and RhoG, triggers F-actin remodeling in arterial endothelial cells, independe
Externí odkaz:
https://doaj.org/article/766d4ed327d94a5ba84fee477abb7f31
Autor:
Wessel S Rodenburg, Jaap D van Buul
Publikováno v:
Vascular Biology, Vol 3, Iss 1, Pp R77-R95 (2021)
Rho GTPases are small signalling G-proteins that are central regulators of cytoskeleton dynamics, and thereby regulate many cellular processes, including the shape, adhesion and migration of cells. As such, Rho GTPases are also essential for the inva
Externí odkaz:
https://doaj.org/article/d6dd3956e96e43f4a57b4f5382d27e3f