Data from Vaccination against Oncoproteins of HPV16 for Noninvasive Vulvar/Vaginal Lesions: Lesion Clearance Is Related to the Strength of the T-Cell Response

Autor: Sjoerd H. van der Burg, Cornelis J.M. Melief, Hans W. Nijman, Theo Stijnen, Gemma G. Kenter, Tjalling Bosse, Gertjan J. Fleuren, J. Hanneke N.G. Oude Elberink, Jaap Oostendorp, A. Rob P.M. Valentijn, Harry Hollema, Toos Daemen, Lorraine M. Fathers, J. Baptist M.Z. Trimbos, Marjolein J. Kagie, Henk W. Schreuder, Marc van Beurden, Bart W.J. Hellebrekers, Edith M.G. van Esch, Ineke L.E. Hamming, Margriet J.G. Löwik, Dorien M.A. Berends-van der Meer, Nikki M. Loof, Linda F.M. Stynenbosch, Renee Vermeij, Marij J.P. Welters, Mariëtte I.E. van Poelgeest

Purpose: Therapeutic vaccination with human papillomavirus type 16 (HPV16) E6 and E7 synthetic long peptides (SLP) is effective against HPV16-induced high-grade vulvar and vaginal intraepithelial neoplasia (VIN/VaIN). However, clinical nonresponders

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90fd8ad0b57ff48e3408370a9dbd37d4
https://doi.org/10.1158/1078-0432.c.6524177.v1

Vaccination against Oncoproteins of HPV16 for Noninvasive Vulvar/Vaginal Lesions: Lesion Clearance Is Related to the Strength of the T-Cell Response

Autor: J Hanneke N G Oude Elberink, Marij J. P. Welters, Marjolein J. Kagie, Nikki M. Loof, Theo Stijnen, Linda F. M. Stynenbosch, Bart W. J. Hellebrekers, Marc van Beurden, Margriet J. G. Löwik, A. Rob P. M. Valentijn, Ineke E. Hamming, Sjoerd H. van der Burg, Tjalling Bosse, Henk W.R. Schreuder, Dorien M A Berends-van der Meer, Hans W. Nijman, Mariëtte I.E. van Poelgeest, Edith M G van Esch, Renee Vermeij, Gert Jan Fleuren, Toos Daemen, J. Baptist Trimbos, Cornelis J. M. Melief, Harry Hollema, Lorraine M. Fathers, Gemma G. Kenter, Jaap Oostendorp

Publikováno v: Clinical cancer research, 22(10), 2342-2350. American Association for Cancer Research Inc.
Clinical Cancer Research, 22(10), 2342-2350. AMER ASSOC CANCER RESEARCH
van Poelgeest, M I E, Welters, M J P, Vermeij, R, Stynenbosch, L F M, Loof, N M, Berends-van der Meer, D M A, Lowik, M J G, Hamming, I L E, van Esch, E M G, Hellebrekers, B W J, van Beurden, M, Schreuder, H W, Kagie, M J, Trimbos, J B M Z, Fathers, L M, Daemen, T, Hollema, H, Valentijn, A R P M, Oostendorp, J, Oude Elberink, H N G, Fleuren, G J, Bosse, T, Kenter, G G, Stijnen, T, Nijman, H W, Melief, C J M & van der Burg, S H 2016, ' Vaccination against Oncoproteins of HPV16 for Noninvasive Vulvar/Vaginal Lesions: Lesion Clearance Is Related to the Strength of the T-Cell Response ', Clinical Cancer Research, vol. 22, no. 10, pp. 2342-2350 . https://doi.org/10.1158/1078-0432.CCR-15-2594
Clinical Cancer Research, 22(10), 2342. American Association for Cancer Research Inc.
Clinical Cancer Research, 22(10), 2342-2350. American Association for Cancer Research Inc.

Purpose: Therapeutic vaccination with human papillomavirus type 16 (HPV16) E6 and E7 synthetic long peptides (SLP) is effective against HPV16-induced high-grade vulvar and vaginal intraepithelial neoplasia (VIN/VaIN). However, clinical nonresponders

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0019df04b3e776a79539df40f209528
https://doi.org/10.1158/1078-0432.ccr-15-2594

The long-term immune response after HPV16 peptide vaccination in women with low-grade pre-malignant disorders of the uterine cervix: a placebo-controlled phase II study

Autor: Linda F. M. Stynenbosch, Marjolein J. Kagie, Bart W. J. Hellebrekers, Tamara H. Ramwadhdoebe, Peggy J. de Vos van Steenwijk, Margriet J. G. Löwik, Mariette I.E. van Poelgeest, Elisabeth M. Osse, Gert Jan Fleuren, Nikki M. Loof, A. Rob P. M. Valentijn, Linda S. Nooij, Jaap Oostendorp, Marij J. P. Welters, Caroline E. van der Minne, Gemma G. Kenter, Sjoerd H. van der Burg, Dorien M A Berends-van der Meer, Lorraine M. Fathers, Cornelis J. M. Melief

Publikováno v: Cancer Immunology, Immunotherapy, 63(2), 147-160

The capacity of a low-dose HPV16 synthetic long-peptide vaccine (HPV16-SLP) to induce an HPV16-specific T-cell response as well as to establish long-term immunologic memory in patients with low-grade abnormalities of the cervix was determined in a pl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1be1718c8e7e848db6c4c06f450f2ce
https://doi.org/10.1007/s00262-013-1499-2

Dendritic cells process synthetic long peptides better than whole protein, improving antigen presentation and T-cell activation

Autor: Jaap Oostendorp, Wim Jiskoot, Anke Redeker, Ferry Ossendorp, Selina Khan, Angelino T. Tromp, Peter A. van Veelen, Kees L. M. C. Franken, Marcel Camps, Sjoerd H. van der Burg, Jan W. Drijfhout, Thorbald van Hall, Rodney A. Rosalia, George M.C. Janssen, Cornelis J. M. Melief, Esther D. Quakkelaar, Luis J. Cruz, Ana Luisa Silva

Publikováno v: European Journal of Immunology. 43:2554-2565

The efficiency of antigen (Ag) processing by dendritic cells (DCs) is vital for the strength of the ensuing T-cell responses. Previously, we and others have shown that in comparison to protein vaccines, vaccination with synthetic long peptides (SLPs)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::13a2bba9f448441e4d572330338c4b6d
https://doi.org/10.1002/eji.201343324

A phase I study for intravenous autologous mesenchymal stromal cell administration to patients with severe emphysema

Autor: W. E. Fibbe, Winifred Broekman, Jan Stolk, Helene Roelofs, Ingeborg M. Bajema, Christian Taube, Thais Mauad, Jaap Jan Zwaginga, Michel I.M. Versteegh, Pieter S. Hiemstra, Jaap Oostendorp

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
QJM: An International Journal of Medicine, 109(5), 331-336
QJM: An International Journal of Medicine

Background : Mesenchymal stromal cells (MSCs) may reduce inflammation and promote tissue repair in pulmonary emphysema. Aim : To study the safety and feasibility of bone marrow-derived autologous (BM-) MSC intravenous administration to patients with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d35b0546d019b7b8265161954f8a1509