Zobrazeno 1 - 10
of 321
pro vyhledávání: '"Jaap, Keijer"'
Autor:
Taolin Yuan, Surinder Kumar, Mary E. Skinner, Ryan Victor-Joseph, Majd Abuaita, Jaap Keijer, Jessica Zhang, Thaddeus J. Kunkel, Yanghan Liu, Elyse M. Petrunak, Thomas L. Saunders, Andrew P. Lieberman, Jeanne A. Stuckey, Nouri Neamati, Fathiya Al-Murshedi, Majid Alfadhel, Johannes N. Spelbrink, Richard Rodenburg, Vincent C.J. de Boer, David B. Lombard
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109991- (2024)
Summary: SIRT5 is a sirtuin deacylase that removes negatively charged lysine modifications, in the mitochondrial matrix and elsewhere in the cell. In benign cells and mouse models, under basal conditions, the phenotypes of SIRT5 deficiency are quite
Externí odkaz:
https://doaj.org/article/1b3e08c25bb044469b8c3e5f02f889fd
Autor:
Bàrbara Reynés, Estefanía García-Ruiz, Evert M. van Schothorst, Jaap Keijer, Paula Oliver, Andreu Palou
Publikováno v:
Biomolecules, Vol 14, Iss 8, p 935 (2024)
(1) Background: Cold exposure induces metabolic adaptations that can promote health benefits, including increased energy disposal due to lipid mobilization in adipose tissue (AT). This study aims to identify easily measurable biomarkers mirroring the
Externí odkaz:
https://doaj.org/article/a8a94e01093e44779d4986a8d0b9e41d
Autor:
Jelle C. B. C. de Jong, Lars Verschuren, Martien P. M. Caspers, Marjanne D. van der Hoek, Feike R. van der Leij, Robert Kleemann, Anita M. van den Hoek, Arie G. Nieuwenhuizen, Jaap Keijer
Publikováno v:
Biology of Sex Differences, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Background Physical weakness is a key component of frailty, and is highly prevalent in older adults. While females have a higher prevalence and earlier onset, sex differences in the development of frailty-related physical weakness are hardly
Externí odkaz:
https://doaj.org/article/8da9ab685829430a8ea35e5ca7a93789
Autor:
Catalina Picó, Empar Lurbe, Jaap Keijer, Jan Kopecky, Jean-François Landrier, Julio Álvarez-Pitti, Jean Charles Martin, Paula Oliver, Andreu Palou, Mariona Palou, Petr Zouhar, Joan Ribot, Ana M. Rodríguez, Juana Sánchez, Francisca Serra, M. Luisa Bonet
Publikováno v:
Frontiers in Pediatrics, Vol 11 (2023)
BackgroundPhysical activity (PA) provides health benefits across the lifespan and improves many established cardiovascular risk factors that have a significant impact on overall mortality. However, discrepancies between self-reported and device-based
Externí odkaz:
https://doaj.org/article/8f388a91f0f24b9cb44d681c1fbe141c
Autor:
Eveline Gart, Wim van Duyvenvoorde, Jessica M. Snabel, Christa de Ruiter, Joline Attema, Martien P.M. Caspers, Serene Lek, Bertie Joan van Heuven, Arjen G.C.L. Speksnijder, Martin Giera, Aswin Menke, Kanita Salic, Kendra K. Bence, Gregory J. Tesz, Jaap Keijer, Robert Kleemann, Martine C. Morrison
Publikováno v:
Heliyon, Vol 9, Iss 3, Pp e13985- (2023)
Background: NAFLD progression, from steatosis to inflammation and fibrosis, results from an interplay of intra- and extrahepatic mechanisms. Disease drivers likely include signals from white adipose tissue (WAT) and gut. However, the temporal dynamic
Externí odkaz:
https://doaj.org/article/80936c4a408e43e2adff608faadaaab7
Publikováno v:
Obesities, Vol 2, Iss 2, Pp 205-214 (2022)
A single-center randomized, controlled cross-over exercise intervention in 20 women willing to reduce weight (20–40 y, BMI: 27.4 ± 2.1), with the aim to examine potential benefits for weight loss under normal (N-Ox: 20.9%) and mildly reduced (R-Ox
Externí odkaz:
https://doaj.org/article/049beb869ced4c98aa59ee8aee883fa1
Autor:
Neeraj Sinha, Evert M. van Schothorst, Guido J. E. J. Hooiveld, Jaap Keijer, Vitor A. P. Martins dos Santos, Maria Suarez-Diez
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-15 (2021)
Abstract Background Several computational methods have been developed that integrate transcriptomics data with genome-scale metabolic reconstructions to increase accuracy of inferences of intracellular metabolic flux distributions. Even though existi
Externí odkaz:
https://doaj.org/article/6f4431891a6e4a50b5861b087c64c3c3
Autor:
Bart Lagerwaard, Arie G. Nieuwenhuizen, Annelies Bunschoten, Vincent C.J. deBoer, Jaap Keijer
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 12, Iss 5, Pp 1214-1231 (2021)
Abstract Background Due to the interaction between skeletal muscle ageing and lifestyle factors, it is often challenging to attribute the decline in muscle mass and quality to either changes in lifestyle or to advancing age itself. Because many of th
Externí odkaz:
https://doaj.org/article/564d6e3f4ca24203a41444efaff044a8
Autor:
Jin Li, Xi Qi, Kennedy S. Ramos, Eva Lanters, Jaap Keijer, Natasja de Groot, Bianca Brundel, Deli Zhang
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 19 (2022)
Background Atrial fibrillation (AF) is the most common and progressive tachyarrhythmia. Diabetes is a common risk factor for AF. Recent research findings revealed that microtubule network disruption underlies AF. The microtubule network mediates the
Externí odkaz:
https://doaj.org/article/cb4959ea7d86455c970c4b1e54c50114
Autor:
Christian J. M. I. Klein, Thomas Budiman, Judith R. Homberg, Dilip Verma, Jaap Keijer, Evert M. van Schothorst
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 16 (2022)
Externí odkaz:
https://doaj.org/article/b7d84311cfd04bd7b9396d100eb467e8