Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Jaanus Remme"'
Autor:
Letian Bao, Josefine Liljeruhm, Rubén Crespo Blanco, Gerrit Brandis, Jaanus Remme, Anthony C. Forster
Publikováno v:
RNA Biology, Vol 21, Iss 1, Pp 31-41 (2024)
Large ribosomal RNAs (rRNAs) are modified heavily post-transcriptionally in functionally important regions but, paradoxically, individual knockouts (KOs) of the modification enzymes have minimal impact on Escherichia coli growth. Furthermore, we rece
Externí odkaz:
https://doaj.org/article/15a54cc1a7e64745a4b170d78474d009
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 10, p 5194 (2024)
Ribosomal RNAs (rRNAs) are extensively modified during the transcription and subsequent maturation. Three types of modifications, 2′-O-methylation of ribose moiety, pseudouridylation, and base modifications, are introduced either by a snoRNA-driven
Externí odkaz:
https://doaj.org/article/eeef5ca0edc841d193b9880ec5b6621f
Publikováno v:
RNA Biology, Vol 19, Iss 1, Pp 1050-1058 (2022)
Delicate variances in the translational machinery affect how efficiently different organisms approach protein synthesis. Determining the scale of this effect, however, requires knowledge on the differences of mistranslation levels. Here, we used a du
Externí odkaz:
https://doaj.org/article/c343da07d34a414093a2d330f8f46710
Publikováno v:
mBio, Vol 13, Iss 5 (2022)
ABSTRACT Bacterial ribosomes are composed of three rRNA and over 50 ribosomal protein (r-protein) molecules. r-proteins are essential for ribosome assembly and structural stability and also participate in almost all ribosome functions. Ribosomal comp
Externí odkaz:
https://doaj.org/article/10f05cbf4c28428faa79a4cf2eccb356
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3128 (2023)
Bacterial ribosomes contain over 50 ribosome core proteins (r-proteins). Tens of non-ribosomal proteins bind to ribosomes to promote various steps of translation or suppress protein synthesis during ribosome hibernation. This study sets out to determ
Externí odkaz:
https://doaj.org/article/c22b10feb2054f4faeffe60e33aa1f2e
Autor:
Shijie Huang, Nikolay A. Aleksashin, Anna B. Loveland, Dorota Klepacki, Kaspar Reier, Amira Kefi, Teresa Szal, Jaanus Remme, Luc Jaeger, Nora Vázquez-Laslop, Andrei A. Korostelev, Alexander S. Mankin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Ribosomes of all organisms have retained 5S rRNA as an autonomous rRNA species. Here the authors engineer a bacterial strain with ribosomes that do not have free 5S rRNA, and carry structural analyses that suggest the evolutionary preservation of 5S
Externí odkaz:
https://doaj.org/article/97ce74dddff14abd9b4d20a9c96f526d
Autor:
Nikolay A. Aleksashin, Margus Leppik, Adam J. Hockenberry, Dorota Klepacki, Nora Vázquez-Laslop, Michael C. Jewett, Jaanus Remme, Alexander S. Mankin
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
The tethered ribosome system Ribo-T supports cell proliferation though at a reduced rate. Here the authors show this is due to slower ribosome assembly instead of reduced functionality.
Externí odkaz:
https://doaj.org/article/dd41dd2510804c7598e1969fe536f5bc
Publikováno v:
Microorganisms, Vol 9, Iss 1, p 25 (2020)
Pseudouridines are known to be important for optimal translation. In this study we demonstrate an unexpected link between pseudouridylation of tRNA and mutation frequency in Pseudomonas species. We observed that the lack of pseudouridylation activity
Externí odkaz:
https://doaj.org/article/70ee423af20a4d72b77a1b1b9fb0f21f
Autor:
Agata L. Starosta, Jürgen Lassak, Lauri Peil, Gemma C. Atkinson, Christopher J. Woolstenhulme, Kai Virumäe, Allen Buskirk, Tanel Tenson, Jaanus Remme, Kirsten Jung, Daniel N. Wilson
Publikováno v:
Cell Reports, Vol 9, Iss 2, Pp 476-483 (2014)
Bacterial ribosomes stall on polyproline stretches and require the elongation factor P (EF-P) to relieve the arrest. Yet it remains unclear why evolution has favored the development of EF-P rather than selecting against the occurrence of polyproline
Externí odkaz:
https://doaj.org/article/23c5b8d5e45d445fb225503be0fc7649
Publikováno v:
Toxins, Vol 11, Iss 2, p 103 (2019)
The potentially self-poisonous toxin-antitoxin modules are widespread in bacterial chromosomes, but despite extensive studies, their biological importance remains poorly understood. Here, we used whole-cell proteomics to study the cellular effects of
Externí odkaz:
https://doaj.org/article/85a7f801582b463dabd4ae5e7191090f