Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jaana Tolvanen"'
Autor:
Hanna-Riikka Heinonen, Annukka Pasanen, Oskari Heikinheimo, Tomas Tanskanen, Kimmo Palin, Jaana Tolvanen, Pia Vahteristo, Jari Sjöberg, Esa Pitkänen, Ralf Bützow, Netta Mäkinen, Lauri A. Aaltonen
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
Abstract Up to 86% of uterine leiomyomas harbour somatic mutations in mediator complex subunit 12 (MED12). These mutations have been associated with conventional histology, smaller tumour size, and larger number of tumours within the uterus. Prior st
Externí odkaz:
https://doaj.org/article/15a7fd008b7b42a49d3e827b391c4772
Autor:
Niko Välimäki, Heli Kuisma, Annukka Pasanen, Oskari Heikinheimo, Jari Sjöberg, Ralf Bützow, Nanna Sarvilinna, Hanna-Riikka Heinonen, Jaana Tolvanen, Simona Bramante, Tomas Tanskanen, Juha Auvinen, Outi Uimari, Amjad Alkodsi, Rainer Lehtonen, Eevi Kaasinen, Kimmo Palin, Lauri A Aaltonen
Publikováno v:
eLife, Vol 7 (2018)
Uterine leiomyomas (ULs) are benign tumors that are a major burden to women’s health. A genome-wide association study on 15,453 UL cases and 392,628 controls was performed, followed by replication of the genomic risk in six cohorts. Effects of the
Externí odkaz:
https://doaj.org/article/94e199383a454da09e3a65af3810b73f
Autor:
Nanna Sarvilinna, Lauri A. Aaltonen, Jaana Tolvanen, Hanna-Riikka Heinonen, Norma Frizzell, Anne Ahtikoski, Pia Vahteristo, Ralf Bützow, Miika Mehine, Outi Uimari, Esa Pitkänen, Netta Mäkinen, Salla Välipakka, Tuomas Heikkinen, Jari Sjöberg, Kati Kämpjärvi
Publikováno v:
British Journal of Cancer
Background: Uterine leiomyomas from hereditary leiomyomatosis and renal cell cancer (HLRCC) patients are driven by fumarate hydratase (FH) inactivation or occasionally by mediator complex subunit 12 (MED12) mutations. The aim of this study was to ana
Autor:
Kimmo Palin, Amjad Alkodsi, Rainer Lehtonen, Tomas Tanskanen, Nanna Sarvilinna, Niko Välimäki, Annukka Pasanen, Jaana Tolvanen, Hanna-Riikka Heinonen, Eevi Kaasinen, Juha Auvinen, Heli Kuisma, Jari Sjöberg, Lauri A. Aaltonen, Ralf Bützow, Outi Uimari, Simona Bramante, Oskari Heikinheimo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a821bde24d3a0979c9db9f29fa89b0f
https://doi.org/10.7554/elife.37110.047
https://doi.org/10.7554/elife.37110.047
Autor:
Oskari Heikinheimo, Kimmo Palin, Jaana Tolvanen, Rainer Lehtonen, Amjad Alkodsi, Simona Bramante, Jari Sjöberg, Annukka Pasanen, Tomas Tanskanen, Niko Välimäki, Eevi Kaasinen, Heli Kuisma, Terhi Piltonen, Lauri A. Aaltonen, Nanna Sarvilinna, Hanna-Riikka Heinonen, Ralf Bützow, Juha Auvinen
Uterine leiomyomas (ULs) are benign tumors that are a major burden to women’s health. A genome-wide association study on 5,417 UL cases and 331,791 controls was performed, followed by replication of the genomic risk in two cohorts. Effects of the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d5526d50fe01566a13fca9dbc6fc6e1
Autor:
Sunil K. Halder, Jason M. Spaeth, Serdar E. Bulun, Ayman Al-Hendy, Min Ju Park, Courtney Failor, Thomas G. Boyer, Jaana Tolvanen, Lauri A. Aaltonen, Jessica E. McLaughlin, Jennifer F. Knudtson, Hailian Shen, Robert S. Schenken, Qiwei Yang
Somatic mutations in exon 2 of the RNA polymerase II transcriptional Mediator subunit MED12 occur at high frequency in uterine fibroids (UFs) and breast fibroepithelial tumors as well as recurrently, albeit less frequently, in malignant uterine leimy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c11516b903287c0c247240351503580
https://europepmc.org/articles/PMC5880139/
https://europepmc.org/articles/PMC5880139/
Autor:
Hanna-Riikka Heinonen, Heli Kuisma, Ralf Bützow, Oskari Heikinheimo, Jari Sjöberg, Simona Bramante, Outi Uimari, Juha Auvinen, Niko Välimäki, Annukka Pasanen, Nanna Sarvilinna, Jaana Tolvanen, Lauri A. Aaltonen, Rainer Lehtonen, Tomas Tanskanen, Kimmo Palin, Amjad Alkodsi, Eevi Kaasinen
Publikováno v:
eLife
eLife, Vol 7 (2018)
eLife, Vol 7 (2018)
Uterine leiomyomas (ULs) are benign tumors that are a major burden to women’s health. A genome-wide association study on 15,453 UL cases and 392,628 controls was performed, followed by replication of the genomic risk in six cohorts. Effects of the
Autor:
Jaana Tolvanen, Lauri A. Aaltonen, Ralf Bützow, Jari Sjöberg, Hanna-Riikka Heinonen, Pia Vahteristo, Annukka Pasanen, Netta Mäkinen, Esa Pitkänen, Kimmo Palin, Oskari Heikinheimo, Tomas Tanskanen
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
Up to 86% of uterine leiomyomas harbour somatic mutations in mediator complex subunit 12 (MED12). These mutations have been associated with conventional histology, smaller tumour size, and larger number of tumours within the uterus. Prior studies, wi
Publikováno v:
Human Reproduction. 27:1865-1869
Hereditary leiomyomatosis and renal cell cancer (HLRCC) is a tumor predisposition syndrome characterized by cutaneous and uterine leiomyomas and renal cell cancer. HLRCC is caused by heterozygous germline mutations in the fumarate hydratase (FH) gene
Autor:
Riku Katainen, Jussi Taipale, Virpi Launonen, Minna Taipale, Taru A. Koski, Jian Yan, Jari Sjöberg, Heli J. Lehtonen, Massimiliano Gentile, Miika Mehine, Pia Vahteristo, Yang Li, Mervi Aavikko, Netta Mäkinen, Elina Virolainen, Eevi Kaasinen, Martin Enge, Tom Böhling, Lauri A. Aaltonen, Jaana Tolvanen
Publikováno v:
Science; Vol 334
Uterine leiomyomas, or fibroids, are benign tumors that affect millions of women worldwide and that can cause considerable morbidity. To study the genetic basis of this tumor type, we examined 18 uterine leiomyomas derived from 17 different patients