In vivo targeting of surface-modified liposomes to metastatically growing colon carcinoma cells and sinusoidal endothelial cells in the rat liver

Autor: Gerrit L. Scherphof, Gerben A. Koning, Jaam Kamps

Publikováno v: Journal of Liposome Research, 7(4), 419-432

We prepared immunoliposomes by covalent coupling of a randomly thiolated monoclonal antibody against the rat colon adenocarcinoma cell line CC531 to MPB-PE on the outer surface of conventional as well as PEGylated liposomes of about 100-nm diameter.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad099f9d2b197d0d44a35f9304008ca6
https://doi.org/10.3109/08982109709035510

Antiproliferative effect of immunoliposomes containing 5-fluorodeoxyuridine-dipalmitate on colon cancer cells

Autor: Gerrit L. Scherphof, Gerben A. Koning, Jaam Kamps, Arko Gorter

Publikováno v: British Jounal of Cancer, 80(11), 1718-1725. Nature Publishing Group
British Journal of Cancer

We have investigated the antiproliferative action towards CC531 colon adenocarcinoma cells of target cell-specific immunoliposomes containing the amphiphilic dipalmitoyl derivative of 5-fluorodeoxyuridine (FUdR-dP). FUdR-dP incorporated in immunolipo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a78a134537eb6763beee33abccc0b6f3
https://research.rug.nl/en/publications/fca69226-415e-4b62-818c-7b9fe248358d

Preparation and characterization of conjugates of (modified) human serum albumin and liposomes: drug carriers with an intrinsic anti-HIV activity

Autor: Hwm Morselt, M P deBéthune, R Pauwels, Dkf Meijer, Piet Swart, E Declercq, Gerrit L. Scherphof, Jaam Kamps

Publikováno v: Biochimica et Biophysica Acta-Biomembranes, 1278(2), 183-190. Elsevier

Human serum albumin (HSA) derivatized with cis-aconitic anhydride (Aco-HSA) that was earlier shown to inhibit replication of human immunodeficiency virus type 1 (HIV-1), was covalently coupled to conventional liposomes, consisting of phosphatidylchol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4f41ed1d602cb50da1296ff505e7709

Recruitment of neutrophils in glomeruli in early mouse sepsis is associated with E-selectin expression and activation of endothelial NF-κB and MAPK pathways.

Autor: Wang Z; Department of Pathology and Medical Biology, Medical Biology Section, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Dayang EZ; Department of Pathology and Medical Biology, Medical Biology Section, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Zwiers PJ; Department of Pathology and Medical Biology, Medical Biology Section, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Hernandez Garcia ML; Department of Pathology and Medical Biology, Medical Biology Section, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Luxen M; Department of Pathology and Medical Biology, Medical Biology Section, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.; Department of Critical Care, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., van Meurs M; Department of Pathology and Medical Biology, Medical Biology Section, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.; Department of Critical Care, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Kamps JAAM; Department of Pathology and Medical Biology, Medical Biology Section, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Moser J; Department of Pathology and Medical Biology, Medical Biology Section, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.; Department of Critical Care, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Molema G; Department of Pathology and Medical Biology, Medical Biology Section, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

Publikováno v: Journal of leukocyte biology [J Leukoc Biol] 2024 Jul 02. Date of Electronic Publication: 2024 Jul 02.

Peroxisome proliferator-activated receptor ɣ agonist mediated inhibition of heparanase expression reduces proteinuria.

Autor: Garsen M; Department of Nephrology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands., Buijsers B; Department of Nephrology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands., Sol M; Division of Medical Biology, Department of Pathology and Medical Biology, University Medical Center Groningen, Groningen, the Netherlands., Gockeln L; Department of Nephrology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands., Sonneveld R; Department of Nephrology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands., van Kuppevelt TH; Department of Biochemistry, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands., de Graaf M; Department of Nephrology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands., van den Born J; Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, Groningen, the Netherlands., Kamps JAAM; Division of Medical Biology, Department of Pathology and Medical Biology, University Medical Center Groningen, Groningen, the Netherlands., van Raalte DH; Diabetes Center, VU University Medical Center, Amsterdam, the Netherlands., van der Meer RW; Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands., Lamb HJ; Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands., Hillebrands JL; Division of Pathology, University Medical Center Groningen, Groningen, the Netherlands., Rabelink TJ; Department of Nephrology and Einthoven Laboratory for Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands., Maciej-Hulme ML; Department of Nephrology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands., Krenning G; Division of Medical Biology, Department of Pathology and Medical Biology, University Medical Center Groningen, Groningen, the Netherlands., Nijenhuis T; Department of Nephrology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands., van der Vlag J; Department of Nephrology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address: Johan.vanderVlag@radboudumc.nl.

Publikováno v: EBioMedicine [EBioMedicine] 2023 Apr; Vol. 90, pp. 104506. Date of Electronic Publication: 2023 Mar 06.