Genome-wide association study of varicose veins identifies a protective missense variant in GJD3 enriched in the Finnish population

Autor: Pyry Helkkula, Shabbeer Hassan, Elmo Saarentaus, Emilia Vartiainen, Sanni Ruotsalainen, Jaakko T. Leinonen, FinnGen, Aarno Palotie, Juha Karjalainen, Mitja Kurki, Samuli Ripatti, Taru Tukiainen

Publikováno v: Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)

A genome-wide association study in a Finnish cohort identifies several new loci associated with varicose veins, including the connexin gene family member, GJD3, as a future druggable target.

Externí odkaz: https://doaj.org/article/842ca7f2401044ee88166fb20aceda48

Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits.

Autor: Suzanne Vogelezang, Jonathan P Bradfield, Tarunveer S Ahluwalia, John A Curtin, Timo A Lakka, Niels Grarup, Markus Scholz, Peter J van der Most, Claire Monnereau, Evie Stergiakouli, Anni Heiskala, Momoko Horikoshi, Iryna O Fedko, Natalia Vilor-Tejedor, Diana L Cousminer, Marie Standl, Carol A Wang, Jorma Viikari, Frank Geller, Carmen Íñiguez, Niina Pitkänen, Alessandra Chesi, Jonas Bacelis, Loic Yengo, Maties Torrent, Ioanna Ntalla, Øyvind Helgeland, Saskia Selzam, Judith M Vonk, Mohammed H Zafarmand, Barbara Heude, Ismaa Sadaf Farooqi, Akram Alyass, Robin N Beaumont, Christian T Have, Peter Rzehak, Jose Ramon Bilbao, Theresia M Schnurr, Inês Barroso, Klaus Bønnelykke, Lawrence J Beilin, Lisbeth Carstensen, Marie-Aline Charles, Bo Chawes, Karine Clément, Ricardo Closa-Monasterolo, Adnan Custovic, Johan G Eriksson, Joaquin Escribano, Maria Groen-Blokhuis, Veit Grote, Dariusz Gruszfeld, Hakon Hakonarson, Torben Hansen, Andrew T Hattersley, Mette Hollensted, Jouke-Jan Hottenga, Elina Hyppönen, Stefan Johansson, Raimo Joro, Mika Kähönen, Ville Karhunen, Wieland Kiess, Bridget A Knight, Berthold Koletzko, Andreas Kühnapfel, Kathrin Landgraf, Jean-Paul Langhendries, Terho Lehtimäki, Jaakko T Leinonen, Aihuali Li, Virpi Lindi, Estelle Lowry, Mariona Bustamante, Carolina Medina-Gomez, Mads Melbye, Kim F Michaelsen, Camilla S Morgen, Trevor A Mori, Tenna R H Nielsen, Harri Niinikoski, Albertine J Oldehinkel, Katja Pahkala, Kalliope Panoutsopoulou, Oluf Pedersen, Craig E Pennell, Christine Power, Sijmen A Reijneveld, Fernando Rivadeneira, Angela Simpson, Peter D Sly, Jakob Stokholm, Kook K Teo, Elisabeth Thiering, Nicholas J Timpson, André G Uitterlinden, Catharina E M van Beijsterveldt, Barbera D C van Schaik, Marc Vaudel, Elvira Verduci, Rebecca K Vinding, Mandy Vogel, Eleftheria Zeggini, Sylvain Sebert, Mads V Lind, Christopher D Brown, Loreto Santa-Marina, Eva Reischl, Christine Frithioff-Bøjsøe, David Meyre, Eleanor Wheeler, Ken Ong, Ellen A Nohr, Tanja G M Vrijkotte, Gerard H Koppelman, Robert Plomin, Pål R Njølstad, George D Dedoussis, Philippe Froguel, Thorkild I A Sørensen, Bo Jacobsson, Rachel M Freathy, Babette S Zemel, Olli Raitakari, Martine Vrijheid, Bjarke Feenstra, Leo-Pekka Lyytikäinen, Harold Snieder, Holger Kirsten, Patrick G Holt, Joachim Heinrich, Elisabeth Widén, Jordi Sunyer, Dorret I Boomsma, Marjo-Riitta Järvelin, Antje Körner, George Davey Smith, Jens-Christian Holm, Mustafa Atalay, Clare Murray, Hans Bisgaard, Mark I McCarthy, Early Growth Genetics Consortium, Vincent W V Jaddoe, Struan F A Grant, Janine F Felix

Publikováno v: PLoS Genetics, Vol 16, Iss 10, p e1008718 (2020)

The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association s

Externí odkaz: https://doaj.org/article/4ad2f9c3808446e988079e02971d10ee

Targeted resequencing of the pericentromere of chromosome 2 linked to constitutional delay of growth and puberty.

Autor: Diana L Cousminer, Jaakko T Leinonen, Antti-Pekka Sarin, Himanshu Chheda, Ida Surakka, Karoliina Wehkalampi, Pekka Ellonen, Samuli Ripatti, Leo Dunkel, Aarno Palotie, Elisabeth Widén

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0128524 (2015)

Constitutional delay of growth and puberty (CDGP) is the most common cause of pubertal delay. CDGP is defined as the proportion of the normal population who experience pubertal onset at least 2 SD later than the population mean, representing 2.3% of

Externí odkaz: https://doaj.org/article/0cffc784171b416aa1a3547e03b86e13

Association of LIN28B with adult adiposity-related traits in females.

Autor: Jaakko T Leinonen, Ida Surakka, Aki S Havulinna, Johannes Kettunen, Riitta Luoto, Veikko Salomaa, Elisabeth Widén

Publikováno v: PLoS ONE, Vol 7, Iss 11, p e48785 (2012)

CONTEXT: Pubertal timing is under strong genetic control and its early onset associates with several adverse health outcomes in adulthood, including obesity, type 2 diabetes and cardiovascular disease. Recent data indicate strong association between

Externí odkaz: https://doaj.org/article/b9c8905d3bce40789303098ba9dff306

Disentangling the link between maternal influences on birth weight and disease risk in 36,211 genotyped mother–child pairs.

Autor: Leinonen, Jaakko T.¹ (AUTHOR), FinnGen (AUTHOR), Pirinen, Matti^1,2,3 (AUTHOR), Tukiainen, Taru¹ (AUTHOR) taru.tukiainen@helsinki.fi

Publikováno v: Communications Biology. 2/12/2024, Vol. 7 Issue 1, p1-9. 9p.