Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jaakko Itkonen"'
Autor:
Jaakko Itkonen, Leo Ghemtio, Daniela Pellegrino, Pia J. Jokela (née Heinonen), Henri Xhaard, Marco G. Casteleijn
Publikováno v:
Pharmaceutics, Vol 14, Iss 8, p 1639 (2022)
Pharmaceutical proteins, compared to small molecular weight drugs, are relatively fragile molecules, thus necessitating monitoring protein unfolding and aggregation during production and post-marketing. Currently, many analytical techniques take offl
Externí odkaz:
https://doaj.org/article/927cd2094a154036a17e0b177537a3c5
Autor:
Jaakko Itkonen, Ada Annala, Shirin Tavakoli, Blanca Arango-Gonzalez, Marius Ueffing, Elisa Toropainen, Marika Ruponen, Marco G. Casteleijn, Arto Urtti
Publikováno v:
Pharmaceutics, Vol 12, Iss 7, p 611 (2020)
Ciliary neurotrophic factor (CNTF) is one of the most studied neuroprotective agents with acknowledged potential in treating diseases of the posterior eye segment. Although its efficacy and mechanisms of action in the retina have been studied extensi
Externí odkaz:
https://doaj.org/article/99494c923b1149c0bd613a2461e20a9c
Autor:
Mariaenrica Frigione, Arto Urtti, Marika Ruponen, Jaakko Itkonen, Marco Biondi, Carla Serri, Laura Mayol, Assunta Borzacchiello
The purpose of this study was to produce poly(DL-lactic-co-glycolic acid) (PLGA) – based microparticles (MPs), externally decorated with hyaluronic acid (HA). The MPs are intended for intravitreal injections in the treatment of posterior eye segmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2bc7517b12e0c9f2550f88acb51ec34
http://hdl.handle.net/11588/768930
http://hdl.handle.net/11588/768930
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Richardson, D, Itkonen, J, Nievas, J, Urtti, A & Casteleijn, M G 2018, ' Accelerated pharmaceutical protein development with integrated cell free expression, purification, and bioconjugation ', Scientific Reports, vol. 8, no. 1, 11967, pp. 2045-2322 . https://doi.org/10.1038/s41598-018-30435-4
Scientific Reports
Richardson, D, Itkonen, J, Nievas, J, Urtti, A & Casteleijn, M G 2018, ' Accelerated pharmaceutical protein development with integrated cell free expression, purification, and bioconjugation ', Scientific Reports, vol. 8, no. 1, 11967, pp. 2045-2322 . https://doi.org/10.1038/s41598-018-30435-4
Scientific Reports
The use of living cells for the synthesis of pharmaceutical proteins, though state-of-the-art, is hindered by its lengthy process comprising of many steps that may affect the protein’s stability and activity. We aimed to integrate protein expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad1433638bd3889e8f1b1aca4fc3b0b3
http://hdl.handle.net/10138/239090
http://hdl.handle.net/10138/239090
Autor:
Emma M. Heikkinen, Maxim Antopolsky, Arto Urtti, Tatu Lajunen, Eva M. del Amo, Elisa Toropainen, Madhushree Bhattacharya, Tiina Turunen, Mechthild Schmitt, Laura Pelkonen, Marika Ruponen, Anna-Kaisa Rimpelä, Dominique Richardson, Kati-Sisko Vellonen, Mika Reinisalo, Jaakko Itkonen, Astrid Subrizi, Otto K. Kari, Heidi Kidron, Eva Ramsay, Marco G. Casteleijn
Publikováno v:
del Amo, E M, Rimpelä, A K, Heikkinen, E, Kari, O K, Ramsay, E, Lajunen, T, Schmitt, M, Pelkonen, L, Bhattacharya, M, Richardson, D, Subrizi, A, Turunen, T, Reinisalo, M, Itkonen, J, Toropainen, E, Casteleijn, M, Kidron, H, Antopolsky, M, Vellonen, K S, Ruponen, M & Urtti, A 2017, ' Pharmacokinetic aspects of retinal drug delivery ', Progress in Retinal and Eye Research, vol. 57, pp. 134-185 . https://doi.org/10.1016/j.preteyeres.2016.12.001
del Amo, E M, Rimpelä, A K, Heikkinen, E, Kari, O K, Ramsay, E, Lajunen, T, Schmitt, M, Pelkonen, L, Bhattacharya, M, Richardson, D, Subrizi, A, Turunen, T, Reinisalo, M, Itkonen, J, Toropainen, E, Casteleijn, M, Kidron, H, Antopolsky, M, Vellonen, K S, Ruponen, M & Urtti, A 2017, ' Pharmacokinetic aspects of retinal drug delivery ', Progress in Retinal and Eye Research, pp. 134-185 . https://doi.org/10.1016/j.preteyeres.2016.12.001
del Amo, E M, Rimpelä, A K, Heikkinen, E, Kari, O K, Ramsay, E, Lajunen, T, Schmitt, M, Pelkonen, L, Bhattacharya, M, Richardson, D, Subrizi, A, Turunen, T, Reinisalo, M, Itkonen, J, Toropainen, E, Casteleijn, M, Kidron, H, Antopolsky, M, Vellonen, K S, Ruponen, M & Urtti, A 2017, ' Pharmacokinetic aspects of retinal drug delivery ', Progress in Retinal and Eye Research, pp. 134-185 . https://doi.org/10.1016/j.preteyeres.2016.12.001
Drug delivery to the posterior eye segment is an important challenge in ophthalmology, because many diseases affect the retina and choroid leading to impaired vision or blindness. Currently, intravitreal injections are the method of choice to adminis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18cf181b5e37561d2b4aa164d45dd287
https://cris.vtt.fi/en/publications/9b1795c0-b5ea-4de1-b3e7-20e7bb65261b
https://cris.vtt.fi/en/publications/9b1795c0-b5ea-4de1-b3e7-20e7bb65261b
Publikováno v:
BMC Biotechnology
Background Neurotrophic factors influence survival, differentiation, proliferation and death of neuronal cells within the central nervous system. Human ciliary neurotrophic factor (hCNTF) has neuroprotective properties and is also known to influence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6feed709bc3d044852955ea00e8d927e
Autor:
Itkonen, Jaakko1 (AUTHOR), Ghemtio, Leo1 (AUTHOR), Pellegrino, Daniela1 (AUTHOR), Jokela, Pia J.1,2 (AUTHOR), Xhaard, Henri3 (AUTHOR), Casteleijn, Marco G.4 (AUTHOR) marco.casteleijn@vtt.fi
Publikováno v:
Pharmaceutics. Aug2022, Vol. 14 Issue 8, p1639-1639. 18p.
Autor:
Kögler, Martin1, Itkonen, Jaakko2, Viitala, Tapani2, Casteleijn, Marco G.2,3 marco.casteleijn@vtt.fi
Publikováno v:
Scientific Reports. 2/12/2020, Vol. 10 Issue 1, p1-11. 11p.
Autor:
Richardson, Dominique1 (AUTHOR), Itkonen, Jaakko1 (AUTHOR), Nievas, Julia1,2 (AUTHOR), Urtti, Arto1,3,4 (AUTHOR), Casteleijn, Marco G.1 (AUTHOR) marco.casteleijn@vtt.fi
Publikováno v:
Scientific Reports. 8/10/2018, Vol. 8 Issue 1, p1-10. 10p.
Autor:
Itkonen, Jaakko1 (AUTHOR) jaakko.itkonen@helsinki.fi, Annala, Ada2,3 (AUTHOR) a.k.a.annala@uu.nl, Tavakoli, Shirin1 (AUTHOR) marco.casteleijn@vtt.fi, Arango-Gonzalez, Blanca4 (AUTHOR) blanca.arango-gonzalez@klinikum.uni-tuebingen.de, Ueffing, Marius4 (AUTHOR) marius.ueffing@uni-tuebingen.de, Toropainen, Elisa2 (AUTHOR) elisa.toropainen@uef.fi, Ruponen, Marika2 (AUTHOR) marika.ruponen@uef.fi, Casteleijn, Marco G.1,5 (AUTHOR), Urtti, Arto1,2,6 (AUTHOR) jaakko.itkonen@helsinki.fi
Publikováno v:
Pharmaceutics. Jul2020, Vol. 12 Issue 7, p611. 1p.