Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jaakko Hentilä"'
Autor:
Ronja Ojala, Nicko Widjaja, Jaakko Hentilä, Anna Jalo, Jatta S. Helin, Tuuli A. Nissinen, Niki Jalava, Olli Eskola, Johan Rajander, Eliisa Löyttyniemi, Kaisa K. Ivaska, Jarna C. Hannukainen
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
ObjectivesObesity impairs bone marrow (BM) glucose metabolism. Adult BM constitutes mostly of adipocytes that respond to changes in energy metabolism by modulating their morphology and number. Here we evaluated whether diet or exercise intervention c
Externí odkaz:
https://doaj.org/article/f1ad33b605eb478aaee7395664d0a3f7
Autor:
Anna Jalo, Jatta S. Helin, Jaakko Hentilä, Tuuli A. Nissinen, Sanna M. Honkala, Marja A. Heiskanen, Eliisa Löyttyniemi, Tarja Malm, Jarna C. Hannukainen
Publikováno v:
Journal of Functional Morphology and Kinesiology, Vol 9, Iss 2, p 58 (2024)
Recent studies have shown that obesity and insulin resistance are associated with increased insulin-stimulated glucose uptake (GU) in the brain. Thus, insulin sensitivity seems to work differently in the brain compared to the peripheral tissues like
Externí odkaz:
https://doaj.org/article/fda9e3b0223a426a8186f7ffcdbc894d
Autor:
Maria K. Jaakkola, Maria Rantala, Anna Jalo, Teemu Saari, Jaakko Hentilä, Jatta S. Helin, Tuuli A. Nissinen, Olli Eskola, Johan Rajander, Kirsi A. Virtanen, Jarna C. Hannukainen, Francisco López-Picón, Riku Klén
Publikováno v:
International Journal of Biomedical Imaging, Vol 2023 (2023)
Clustering time activity curves of PET images have been used to separate clinically relevant areas of the brain or tumours. However, PET image segmentation in multiorgan level is much less studied due to the available total-body data being limited to
Externí odkaz:
https://doaj.org/article/6aa8f6b2dabe4568b37638f9a31ae1fe
Autor:
Marja A. Heiskanen, Sanna M. Honkala, Jaakko Hentilä, Ronja Ojala, Riikka Lautamäki, Kalle Koskensalo, Martin S. Lietzén, Virva Saunavaara, Jani Saunavaara, Mika Helmiö, Eliisa Löyttyniemi, Lauri Nummenmaa, Maria C. Collado, Tarja Malm, Leo Lahti, Kirsi H. Pietiläinen, Jaakko Kaprio, Juha O. Rinne, Jarna C. Hannukainen
Publikováno v:
BMC Sports Science, Medicine and Rehabilitation, Vol 13, Iss 1, Pp 1-19 (2021)
Abstract Background Obesity and physical inactivity are major global public health concerns, both of which increase the risk of insulin resistance and type 2 diabetes. Regulation of glucose homeostasis involves cross-talk between the central nervous
Externí odkaz:
https://doaj.org/article/979ea431ecc44ff79335f46846843495
Autor:
Tuuli A. Nissinen, Jaakko Hentilä, Fabio Penna, Anita Lampinen, Juulia H. Lautaoja, Vasco Fachada, Tanja Holopainen, Olli Ritvos, Riikka Kivelä, Juha J. Hulmi
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 9, Iss 3, Pp 514-529 (2018)
Abstract Background Cancer cachexia increases morbidity and mortality, and blocking of activin receptor ligands has improved survival in experimental cancer. However, the underlying mechanisms have not yet been fully uncovered. Methods The effects of
Externí odkaz:
https://doaj.org/article/8b4386525c204ba9bbc5c04414cf63e4
Autor:
Jaakko Hentilä, Tuuli A. Nissinen, Ayhan Korkmaz, Sanna Lensu, Mika Silvennoinen, Arja Pasternack, Olli Ritvos, Mustafa Atalay, Juha J. Hulmi
Publikováno v:
Frontiers in Physiology, Vol 9 (2019)
Muscle wasting in cancer cachexia can be alleviated by blocking activin receptor type 2 (ACVR2) ligands through changes in protein synthesis/degradation. These changes in cellular and protein metabolism may alter protein homeostasis. First, we elucid
Externí odkaz:
https://doaj.org/article/fcc274b2723e468cb0c439b80c40a940
Autor:
Satu Pekkala, Anniina Keskitalo, Emilia Kettunen, Sanna Lensu, Noora Nykänen, Teijo Kuopio, Olli Ritvos, Jaakko Hentilä, Tuuli A. Nissinen, Juha J. Hulmi
Publikováno v:
Cancers, Vol 11, Iss 11, p 1799 (2019)
Colorectal cancer (CRC) and cachexia are associated with the gut microbiota and microbial surface molecules. We characterized the CRC-associated microbiota and investigated whether cachexia affects the microbiota composition. Further, we examined the
Externí odkaz:
https://doaj.org/article/305a86d8f5894985a273ab47d675bfbb
Autor:
Marko Korhonen, Eija K. Laakkonen, Jaakko Hentilä, Juha P. Ahtiainen, Harri Suominen, Juha J. Hulmi
Publikováno v:
Medicine & Science in Sports & Exercise. 52:1948-1959
Purpose Exercise and aging may modulate muscle protein homeostasis and autophagy, but few studies examine highly-trained middle-aged or older individuals. This study elucidated the effects of a new long-term training stimulus on markers of muscle aut
Autor:
Tuuli A. Nissinen, Arja Pasternack, Juulia H. Lautaoja, Juha J. Hulmi, Vasco Fachada, Olli Ritvos, Jaakko Hentilä, Riikka Kivelä
Blocking of myostatin and activins effectively counteracts muscle atrophy. However, the potential interaction with physical inactivity and fasting in the regulation of muscle protein synthesis is poorly understood. We used blockade of myostatin and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1929988bb0c9232bd1379331d6118fa5
http://urn.fi/URN:NBN:fi:jyu-202102121630
http://urn.fi/URN:NBN:fi:jyu-202102121630
Autor:
Jaakko, Hentilä, Juha J, Hulmi, Eija K, Laakkonen, Juha P, Ahtiainen, Harri, Suominen, Marko T, Korhonen
Publikováno v:
Medicine and science in sports and exercise. 52(9)
Exercise and aging may modulate muscle protein homeostasis and autophagy, but few studies examine highly trained middle-age or older individuals. This study elucidated the effects of a new long-term training stimulus on markers of muscle autophagy an