Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jaakko, Lehtimäki"'
Autor:
Qian Wu, Euclides Sacomboio, Lara Valente de Souza, Rui Martins, Jamil Kitoko, Sílvia Cardoso, Temitope W. Ademolue, Tiago Paixão, Jaakko Lehtimäki, Ana Figueiredo, Caren Norden, Pierre-Louis Tharaux, Guenter Weiss, Fudi Wang, Susana Ramos, Miguel P. Soares
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112057- (2023)
Summary: Iron recycling prevents the development of anemia under homeostatic conditions. Whether iron recycling was co-opted as a defense strategy to prevent the development of anemia in response to infection is unclear. We find that in severe Plasmo
Externí odkaz:
https://doaj.org/article/b51c6269e0044623b4090c20d9799e29
Autor:
Yaming Jiu, Jaakko Lehtimäki, Sari Tojkander, Fang Cheng, Harri Jäälinoja, Xiaonan Liu, Markku Varjosalo, John E. Eriksson, Pekka Lappalainen
Publikováno v:
Cell Reports, Vol 11, Iss 10, Pp 1511-1518 (2015)
The actin cytoskeleton and cytoplasmic intermediate filaments contribute to cell migration and morphogenesis, but the interplay between these two central cytoskeletal elements has remained elusive. Here, we find that specific actin stress fiber struc
Externí odkaz:
https://doaj.org/article/3275f3efdc2548269554e14708fbdefd
Autor:
Susana Lechuga, Alexander X. Cartagena‐Rivera, Afshin Khan, Bert I. Crawford, Vani Narayanan, Daniel E. Conway, Jaakko Lehtimäki, Pekka Lappalainen, Florian Rieder, Michelle S. Longworth, Andrei I. Ivanov
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a1f8b663a5515e6483f490f28f02e43
https://doi.org/10.1096/fasebj.2022.36.s1.r2970
https://doi.org/10.1096/fasebj.2022.36.s1.r2970
Autor:
Qian Wu, Euclides Sacomboio, Lara Valente de Souza, Rui Martins, Sílvia Cardoso, Temitope W. Ademolue, Tiago Paixão, Jaakko Lehtimäki, Caren Norden, Pierre-Louis Tharaux, Guenter Weiss, Fudi Wang, Susana Ramos, Miguel P. Soares
Publikováno v:
bioRxiv
Anemia is a clinical hallmark and independent risk factor of malaria mortality, the disease caused by Plasmodium spp. infection. While malarial anemia arises from parasite-induced hemolysis, whether and how host metabolic adaptation to malaria regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bb7e0398b3e32613611fe5f90395dc1
https://doi.org/10.1101/2022.01.12.475857
https://doi.org/10.1101/2022.01.12.475857
Autor:
Diti Desai, Jaakko Lehtimäki, Tove J. Grönroos, Jouko Sandholm, Johanna Tuomela, Jixi Zhang, Jessica M. Rosenholm
Publikováno v:
Molecular Pharmaceutics. 14:3218-3227
Zoledronic acid (ZOL) is a nitrogen-containing bisphosphonate used for the treatment of bone diseases and calcium metabolism. Anticancer activity of ZOL has been established, but its extraskeletal effects are limited due to its rapid uptake and accum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed72145ab1427b28b139eb2017ab4761
https://doi.org/10.1021/acs.molpharmaceut.7b00519
https://doi.org/10.1021/acs.molpharmaceut.7b00519
Autor:
Kevin W. Harris, Jeremy Clark, Jouko Sandholm, Aleksi Schrey, Arja Jukkola-Vuorinen, Jaakko Lehtimäki, Pirkko Härkönen, Katri S. Selander, Johanna Tuomela, Sadanandan E. Velu, Tamiko Ishizu
Publikováno v:
Oncotarget
// Jouko Sandholm 1 , Jaakko Lehtimaki 2 , Tamiko Ishizu 2, 3 , Sadanandan E. Velu 4 , Jeremy Clark 4 , Pirkko Harkonen 2 , Arja Jukkola-Vuorinen 5 , Aleksi Schrey 6 , Kevin W. Harris 7, 8, 9 , Johanna M. Tuomela 2 , Katri S. Selander 4, 10 1 Cell Im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27bb071587aaa492569f53f630360fd1
http://europepmc.org/articles/PMC5349995
http://europepmc.org/articles/PMC5349995
Autor:
Piotr Prus, S. Pauliina Turunen, Jaakko Lehtimäki, Chunguang Wang, Sohvi Hörkkö, Marja Veneskoski, Outi Kummu
Publikováno v:
Immunology. 141:416-430
Summary Oxidized low-density lipoprotein (OxLDL) plays a crucial role in the development of atherosclerosis. Carbamylated LDL has been suggested to promote atherogenesis in patients with chronic kidney disease. Here we observed that plasma IgG and Ig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::035c6a80eeabde681b8c334a8296591b
https://doi.org/10.1111/imm.12204
https://doi.org/10.1111/imm.12204
Autor:
Juha Risteli, Outi Kummu, Y. Antero Kesäniemi, Marja Veneskoski, Jaakko Lehtimäki, S. Pauliina Turunen, Sohvi Hörkkö, Helena Kastarinen, Chunguang Wang, Marja Kaisa Koivula
Publikováno v:
Antioxidants & Redox Signaling. 19:1047-1062
Post-translational modification of proteins via carbamylation predicts increased risk for coronary artery disease. Uremia and smoke exposure are known to increase carbamylation. The aim was to investigate the role of carbamylated low-density lipoprot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b96995656d42df85f24c5962e0a0872
https://doi.org/10.1089/ars.2012.4535
https://doi.org/10.1089/ars.2012.4535
Autor:
Outi Kummu, Sohvi Hörkkö, Jaakko Lehtimäki, Chunguang Wang, Antti E. Nissinen, S. Pauliina Turunen, Marja Veneskoski
Publikováno v:
International Immunology. 25:575-587
Malondialdehyde acetaldehyde (MAA) adducts are generated under oxidative stress and shown to be highly immunogenic. Our aim was to investigate the recognition of MAA adducts by human natural antibodies in newborns before or at the time of full-term p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a07a84e540a4e4390932e2fc56f97e9a
https://doi.org/10.1093/intimm/dxt022
https://doi.org/10.1093/intimm/dxt022
Publikováno v:
Handbook of experimental pharmacology. 235
Cell migration is necessary for several developmental processes in multicellular organisms. Furthermore, many physiological processes such as wound healing and immunological events in adult animals are dependent on cell migration. Consequently, defec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b666fda89f1207a5a864ff591e86755c
https://pubmed.ncbi.nlm.nih.gov/27469496
https://pubmed.ncbi.nlm.nih.gov/27469496