Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Jaakko, Lappalainen"'
Autor:
Katarina Varnäs, Christer Halldin, Lars Farde, Svante Nyberg, Per Stenkrona, Alan J. Cross, Aurelija Jucaite, Zsolt Cselényi, Jaakko Lappalainen, Chi-Ming Lee, Dennis J. McCarthy
Publikováno v:
Psychopharmacology
Rationale Sedation, dependence, and abuse liability limit the use of non-selective γ-aminobutyric acid (GABAA) receptor positive modulators for the treatment of anxiety. AZD7325 and AZD6280 are novel, subtype-selective GABAAα2,3 receptor positive m
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology
Naloxegol is a polyethylene glycol derivative of naloxone approved in the US as a once-daily oral treatment for opioid-induced constipation (OIC) in adults with chronic noncancer pain. Population exposure-response models were constructed based on dat
Autor:
Jaakko Lappalainen, Jari Siironen, Juha Hernesniemi, Riku Kivisaari, Rahul Raj, Markus B. Skrifvars
Publikováno v:
Journal of Neurotrauma. 32:95-100
The effect of blood alcohol concentration (BAC) on outcome after traumatic brain injury (TBI) is controversial. We sought to assess the independent effect of positive BAC on long-term outcome in patients with TBI treated in the intensive care unit (I
Autor:
Joop M. A. van Gerven, Jaakko Lappalainen, Mark A. Smith, Alan J. Cross, Gabriel E. Jacobs, Xia Chen, Marieke de Kam, Adam F. Cohen, Judith Jaeger, Paul Maruff
Publikováno v:
British Journal of Clinical Pharmacology. 78:1298-1314
Aims AZD7325 is a novel α2,3-subtype-selective partial GABA-A-receptor modulator. This study investigated the pharmacodynamics of single oral doses of AZD7325 2 mg and 10 mg on the central nervous system (CNS) compared with placebo and lorazepam 2 m
Publikováno v:
Journal of opioid management. 12(6)
Objective: To compare the long-term safety and tolerability of naloxegol with placebo in patients with opioid-induced constipation (OIC) and noncancer pain. Design: Twelve-week, multicenter, randomized, double-blind, parallel-group phase 3 extension
Autor:
Jaakko Lappalainen, Erik T. te Beek, Xia Chen, Joop M. A. van Gerven, Kimberly J. Nahon, Alan J. Cross, Justin L. Hay, Gabriel E. Jacobs, Marieke L. de Kam
Publikováno v:
Clinical Pharmacology in Drug Development. 4:149-154
Compounds with selectivity for GABAA receptor subtypes may differ significantly from nonselective benzodiazepines in their dopaminergic effects in vivo. To explore the exact role of the GABAA receptor subtypes in the regulation of prolactin secretion
Publikováno v:
Alimentary Pharmacology & Therapeutics. 40:771-779
SummaryBackground Opioid-induced constipation (OIC) is a common adverse effect of opioid therapy. Aim To evaluate the long-term safety and tolerability of naloxegol, an oral, peripherally acting μ-opioid receptor antagonist (PAMORA), in patients wit
Publikováno v:
ICCS
Procedia Computer Science
Procedia Computer Science
Current research on physical or natural phenomena produces large datasets used by scientists to prove or disprove hypotheses. The increasing detail of our science triggers the trend of Big Data, and introduces new challenges on managing and processin
Publikováno v:
ICCS
Current Research Information Systems (CRISs) enable the maintenance of information related to research activities of organizations and their members, including outputs or products from these activities. Such contextual information is of uttermost imp
Publikováno v:
Journal of Neurosurgery. 110:989-995
Object After aneurysmal subarachnoid hemorrhage (SAH), conflicting results concerning an association between the APOE genotype and impaired outcome have been reported. The authors tested prospectively whether APOE ε2 or ε4 allele–containing genot