Non-viral reprogramming of human nucleus pulposus cells with FOXF1 via extracellular vesicle delivery: an in vitro and in vivo study

Autor: S Tang, A Salazar-Puerta, J Richards, S Khan, JA Hoyland, D Gallego-Perez, B Walter, N Higuita-Castro, D Purmessur

Publikováno v: European Cells & Materials, Vol 41, Pp 90-107 (2021)

Intervertebral disc (IVD) degeneration is characterized by decreased cellularity and proteoglycan synthesis and increased inflammation, catabolism, and neural/vascular ingrowth. Regenerative methods for IVD degeneration are largely cell-therapy-based

Externí odkaz: https://doaj.org/article/cb211c1e7d374691b4058d8ad627cead

Use of genetically modified muscle and fat grafts to repair defects in bone and cartilage

Autor: CH Evans, F-J Liu, V Glatt, JA Hoyland, C Kirker-Head, A Walsh, O Betz, JW Wells, V Betz, RM Porter, FA Saad, LC Gerstenfeld, TA Einhorn, MB Harris, MS Vrahas

Publikováno v: European Cells & Materials, Vol 18, Pp 96-111 (2009)

We report a novel technology for the rapid healing of large osseous and chondral defects, based upon the genetic modification of autologous skeletal muscle and fat grafts. These tissues were selected because they not only possess mesenchymal progenit

Externí odkaz: https://doaj.org/article/275062650e1e418cb487d4ca3896b564

P40. PDGF expression in normally healing human fractures

Autor: JG Andrew, JA Hoyland, AJ Freemont, DR Marsh

Publikováno v: Bone. 15:239-240

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fd2fc477bcd9a4349417dfb569713ff2
https://doi.org/10.1016/8756-3282(94)90773-0

O7. Sequential expression of cartilage and bone phenotypes by cells in normally healing human fractures

Autor: JG Andrew, JA Hoyland, AJ Freemont, DR Marsh

Publikováno v: Bone. 15:230

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ff8717827acdb75ce8c2e6820eb4f261
https://doi.org/10.1016/8756-3282(94)90733-1

Engineered extracellular vesicle-based gene therapy for the treatment of discogenic back pain.

Autor: Tang SN; Department of Biomedical Engineering, College of Engineering, The Ohio State University, USA., Salazar-Puerta AI; Department of Biomedical Engineering, College of Engineering, The Ohio State University, USA., Heimann MK; Department of Biomedical Engineering, College of Engineering, The Ohio State University, USA., Kuchynsky K; Department of Biomedical Engineering, College of Engineering, The Ohio State University, USA., Rincon-Benavides MA; Biophysics Graduate Program, The Ohio State University, USA., Kordowski M; Biophysics Graduate Program, The Ohio State University, USA., Gunsch G; Department of Biomedical Engineering, College of Engineering, The Ohio State University, USA., Bodine L; Department of Mechanical Engineering, College of Engineering, The Ohio State University, USA., Diop K; Department of Biology, College of Arts and Sciences, The Ohio State University, USA., Gantt C; Department of Biomedical Engineering, College of Engineering, The Ohio State University, USA., Khan S; Department of Orthopedics, The Ohio State University Wexner Medical Center, USA., Bratasz A; Small Animal Imaging Center Shared Resources, Wexner Medical Center, USA., Kokiko-Cochran O; Department of Neuroscience, The Ohio State University, USA; Institute for Behavioral Medicine Research, Neurological Institute, The Ohio State University, USA., Fitzgerald J; Department of Neuroscience, The Ohio State University, USA; Institute for Behavioral Medicine Research, Neurological Institute, The Ohio State University, USA., Laudier DM; Leni and Peter W. May Department of Orthopaedics, Icahn School of Medicine at Mount Sinai, USA., Hoyland JA; Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, The University of Manchester, Manchester, UK; NIHR Manchester Musculoskeletal Biomedical Research Centre, Manchester University, NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK., Walter BA; Department of Biomedical Engineering, College of Engineering, The Ohio State University, USA; Department of Orthopedics, The Ohio State University Wexner Medical Center, USA., Higuita-Castro N; Department of Biomedical Engineering, College of Engineering, The Ohio State University, USA; Biophysics Graduate Program, The Ohio State University, USA; Department of Neurosurgery, The Ohio State University, USA; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, USA. Electronic address: Higuitacastro.1@osu.edu., Purmessur D; Department of Biomedical Engineering, College of Engineering, The Ohio State University, USA; Department of Orthopedics, The Ohio State University Wexner Medical Center, USA. Electronic address: Purmessurwalter.1@osu.edu.

Publikováno v: Biomaterials [Biomaterials] 2024 Jul; Vol. 308, pp. 122562. Date of Electronic Publication: 2024 Apr 01.