Zobrazeno 1 - 10
of 295
pro vyhledávání: '"Ja‐Lok Ku"'
Autor:
Soon-Chan Kim, Min Jung Kim, Ji Won Park, Young-Kyoung Shin, Seung-Yong Jeong, Sungwan Kim, Ja-Lok Ku
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Cellular and molecular dynamics of human cells are constantly affected by gravity. Alteration of the gravitational force disturbs the cellular equilibrium, which might modify physiological and molecular characteristics. Nevertheless, biologi
Externí odkaz:
https://doaj.org/article/f5869a34131e43979d8b24a4ba595a61
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Sarcomas, malignant tumors from mesenchymal tissues, exhibit poor prognosis despite advancements in treatment modalities such as surgery, radiotherapy, and chemotherapy, with doxorubicin being a cornerstone treatment. Resistance to doxorubic
Externí odkaz:
https://doaj.org/article/21f890e2a3414a9498dfc915e001c148
Autor:
Sangyeop Hyun, Youngmin Han, Jae Yun Moon, Young‐Ah Suh, Won‐Gun Yun, Wooil Kwon, Jong‐Eun Lee, Daeun Kim, Ja‐Lok Ku, Jin‐Young Jang, Daechan Park
Publikováno v:
Cancer Communications, Vol 44, Iss 8, Pp 921-925 (2024)
Externí odkaz:
https://doaj.org/article/f14a639effd84323992b0aa34fa099e6
Autor:
Yona Kim, Ji Hyeon You, Yeonjoo Ryu, Gyuri Park, Urim Lee, Hyo Eun Moon, Hye Ran Park, Chang W. Song, Ja-Lok Ku, Sung-Hye Park, Sun Ha Paek
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-16 (2024)
Abstract Glioblastoma (GBM), the most lethal primary brain cancer, exhibits intratumoral heterogeneity and molecular plasticity, posing challenges for effective treatment. Despite this, the regulatory mechanisms underlying such plasticity, particular
Externí odkaz:
https://doaj.org/article/2a87bad4a8154cc9969bb2a939983550
Autor:
Sarah S. Wang, Madison L. Hall, EunJung Lee, Soon-Chan Kim, Neha Ramesh, Sang Hyub Lee, Jin-Young Jang, Richard J. Bold, Ja-Lok Ku, Chang-Il Hwang
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109414- (2024)
Summary: In pancreatic ductal adenocarcinoma (PDAC), no recurrent metastasis-specific mutation has been found, suggesting that epigenetic mechanisms, such as DNA methylation, are the major contributors of late-stage disease progression. Here, we perf
Externí odkaz:
https://doaj.org/article/b585b1d868174aa89f6764d299282f5f
Autor:
Soon-Chan Kim, Young-Eun Cho, Young-Kyoung Shin, Hyeon Jong Yu, Tamrin Chowdhury, Sojin Kim, Kyung Sik Yi, Chi-Hoon Choi, Sang-Hoon Cha, Chul-Kee Park, Ja-Lok Ku
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-15 (2023)
Abstract Glioblastoma (GBM) is the most lethal intracranial tumor. Sequencing technologies have supported personalized therapy for precise diagnosis and optimal treatment of GBM by revealing clinically actionable molecular characteristics. Although a
Externí odkaz:
https://doaj.org/article/d8555ba98b0944cc98c9445c006e11d0
Autor:
Ji-Won Huh, Min Jung Kim, Jaesik Kim, Hyeon Gwon Lee, Seung-Bum Ryoo, Ja-Lok Ku, Seung-Yong Jeong, Kyu Joo Park, Dokyoon Kim, Jihyun F. Kim, Ji Won Park
Publikováno v:
Microbiome, Vol 10, Iss 1, Pp 1-14 (2022)
Abstract Background A significant proportion of colorectal cancer (CRC) patients suffer from early recurrence and progression after surgical treatment. Although the gut microbiota is considered as a key player in the initiation and progression of CRC
Externí odkaz:
https://doaj.org/article/dbdacbf2dec0480d93f758c6c8392a43
Autor:
Sojin Kim, Tamrin Chowdhury, Hyeon Jong Yu, Jee Ye Kahng, Chae Eun Lee, Seung Ah. Choi, Kyung-Min Kim, Ho Kang, Joo Ho Lee, Soon-Tae Lee, Jae-Kyung Won, Kyung Hyun Kim, Min-Sung Kim, Ji Yeoun Lee, Jin Wook Kim, Yong-Hwy Kim, Tae Min Kim, Seung Hong Choi, Ji Hoon Phi, Young-Kyoung Shin, Ja-Lok Ku, Sungyoung Lee, Hongseok Yun, Hwajin Lee, Dokyoung Kim, Kyoungmi Kim, Junho K. Hur, Sung-Hye Park, Seung-Ki Kim, Chul-Kee Park
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-16 (2022)
Abstract Background The activation of the telomere maintenance mechanism (TMM) is one of the critical drivers of cancer cell immortality. In gliomas, TERT expression and TERT promoter mutation are considered to reliably indicate telomerase activation
Externí odkaz:
https://doaj.org/article/f8118b5a57eb4e34a8c2820b80aa8ed9
Autor:
Jee Hyung Lee, Haeryoung Kim, Sang Hyub Lee, Ja-Lok Ku, Jung Won Chun, Ha Young Seo, Soon Chan Kim, Woo Hyun Paik, Ji Kon Ryu, Sang Kook Lee, Andrew M. Lowy, Yong-Tae Kim
Publikováno v:
Gut and Liver, Vol 16, Iss 4, Pp 625-636 (2022)
Background/Aims: Three-dimensional cultures of human pancreatic cancer tissue also known as “organoids” have largely been developed from surgical specimens. Given that most patients present with locally advanced and/or metastatic disease, such or
Externí odkaz:
https://doaj.org/article/10db783526254b6fa2e792747897acb9
Autor:
Nahyun Jeong, Soon-Chan Kim, Ji Won Park, Seul Gi Park, Ki-Hoan Nam, Ja Oh Lee, Young-Kyoung Shin, Jeong Mo Bae, Seung-Yong Jeong, Min Jung Kim, Ja-Lok Ku
Publikováno v:
npj Genomic Medicine, Vol 7, Iss 1, Pp 1-15 (2022)
Abstract Multifocal colorectal cancer (CRC) comprises both clonally independent primary tumors caused by inherited predisposition and clonally related tumors mainly due to intraluminal spreading along an intact basement membrane. The distinction betw
Externí odkaz:
https://doaj.org/article/82d38148d7234671be9ddd099e656ac2