Metabolomics Study of LY3020371, a potent and selective mGlu2/3 receptor antagonist, and Ketamine in Rats

Autor: M Kuo, V Tolstikov, A Nikolayev, H Wu, JM Witkin, JA Monn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a0bc5849f6659e489dc08dbbcf6d7921

Effect of the mGluR2/3 agonist, LY354740 on schedule-controlled behaviour in rats

Autor: NA Moore, G Rees, B Tree, JA Monn

Publikováno v: Behavioural Pharmacology. 8:659

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dbe9887c52dbe78df5003c64fc8be144
https://doi.org/10.1097/00008877-199711000-00061

mGlu3 Metabotropic Glutamate Receptors as a Target for the Treatment of Absence Epilepsy: Preclinical and Human Genetics Data.

Autor: Celli R; I.R.C.C.S. Neuromed, Pozzilli, Italy., Striano P; Department Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genova, Italy.; I.R.C.C.S. 'G. Gaslini' Institute, Genova, Italy., Citraro R; University of Catanzaro, School of Medicine, Science of Health Department, FAS@UMG Research Center, Catanzaro, Italy., Di Menna L; I.R.C.C.S. Neuromed, Pozzilli, Italy., Cannella M; I.R.C.C.S. Neuromed, Pozzilli, Italy., Imbriglio T; I.R.C.C.S. Neuromed, Pozzilli, Italy., Koko M; Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany., Euro Epinomics-Cogie Consortium; SEE Appendix 1 EuroEPINOMICS-CoGIE Consortium., De Sarro G; University of Catanzaro, School of Medicine, Science of Health Department, FAS@UMG Research Center, Catanzaro, Italy., Monn JA; I.R.C.C.S. Neuromed, Pozzilli, Italy., Battaglia G; I.R.C.C.S. Neuromed, Pozzilli, Italy.; Department of Physiology and Pharmacology, University Sapienza, Rome, Italy., Luijtelaar GV; Donders Center for Cognition, Radboud University, Nijmegen, the Netherlands., Nicoletti F; I.R.C.C.S. Neuromed, Pozzilli, Italy.; Department of Physiology and Pharmacology, University Sapienza, Rome, Italy., Russo E; University of Catanzaro, School of Medicine, Science of Health Department, FAS@UMG Research Center, Catanzaro, Italy., Leo A; University of Catanzaro, School of Medicine, Science of Health Department, FAS@UMG Research Center, Catanzaro, Italy.

Publikováno v: Current neuropharmacology [Curr Neuropharmacol] 2023; Vol. 21 (1), pp. 105-118.

The bacterial quorum sensing molecule, 2-heptyl-3-hydroxy-4-quinolone (PQS), inhibits signal transduction mechanisms in brain tissue and is behaviorally active in mice.

Autor: Di Menna L; IRCCS Neuromed, Pozzilli, Italy., Busceti CL; IRCCS Neuromed, Pozzilli, Italy., Ginerete RP; IRCCS Neuromed, Pozzilli, Italy., D'Errico G; IRCCS Neuromed, Pozzilli, Italy., Orlando R; IRCCS Neuromed, Pozzilli, Italy; Department of Physiology and Phamacology, Sapienza University, Roma, Italy., Alborghetti M; Department of Neuroscience, Mental Health, and Sensory Organs, Sapienza University, Italy., Bruno V; IRCCS Neuromed, Pozzilli, Italy; Department of Physiology and Phamacology, Sapienza University, Roma, Italy., Battaglia G; IRCCS Neuromed, Pozzilli, Italy; Department of Physiology and Phamacology, Sapienza University, Roma, Italy., Fornai F; IRCCS Neuromed, Pozzilli, Italy; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Italy., Leoni L; Department of Science, Roma Tre University, Roma, Italy., Rampioni G; Department of Science, Roma Tre University, Roma, Italy; Fondazione Santa Lucia IRCCS, Roma, Italy., Visca P; Department of Science, Roma Tre University, Roma, Italy; Fondazione Santa Lucia IRCCS, Roma, Italy., Monn JA; IRCCS Neuromed, Pozzilli, Italy., Nicoletti F; IRCCS Neuromed, Pozzilli, Italy; Department of Physiology and Phamacology, Sapienza University, Roma, Italy. Electronic address: nicoletti@neuromed.it.

Publikováno v: Pharmacological research [Pharmacol Res] 2021 Aug; Vol. 170, pp. 105691. Date of Electronic Publication: 2021 May 25.

Synthesis and Pharmacological Characterization of C4 β -Amide-Substituted 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1 S,2 S,4 S,5 R,6 S)-2-Amino-4-[(3-methoxybenzoyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2794193), a Highly Potent and Selective mGlu 3 Receptor Agonist.

Autor: Monn JA, Henry SS, Massey SM, Clawson DK, Chen Q, Diseroad BA, Bhardwaj RM, Atwell S, Lu F, Wang J, Russell M, Heinz BA, Wang XS, Carter JH, Getman BG, Adragni K, Broad LM, Sanger HE, Ursu D, Catlow JT, Swanson S, Johnson BG, Shaw DB, McKinzie DL, Hao J

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2018 Mar 22; Vol. 61 (6), pp. 2303-2328. Date of Electronic Publication: 2018 Feb 06.