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Sequence-Selective Recognition of Duplex DNA through Covalent Interstrand Cross-Linking: Kinetic and Molecular Modeling Studies with Pyrrolobenzodiazepine Dimers

Autor: D. S. Bose, Melissa Smellie, JA Hartley, David E. Thurston, Andrew S. Thompson, Terence C. Jenkins

Publikováno v: Biochemistry. 42:8232-8239

Members of a homologous series of pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers with C8-O-(CH(2))(n)-O-C8' diether linkages (n = 3-6 for 2a-d, respectively) have been studied for their ability to interact with oligonucleotide duplexes containing pot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b1674c1d625e0fe00ab349ea244b95
https://doi.org/10.1021/bi034313t

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DNA damage and sequence specificity of DNA binding of the new anti-cancer agent 1,4-bis(2'-chloroethyl)-1,4-diazabicyclo-[2.2.1] heptane dimaleate (Dabis maleate)

Autor: Kw Kohn, Massimo Broggini, W. B. Mattes, Maurizio D'Incalci, Mauro Ponti, Ja Hartley

Publikováno v: British Journal of Cancer

The DNA damage and the sequence specificity of guanine-N7 alkylation produced by the novel, positively charged, antineoplastic agent 1,4-bis(2'-chloroethyl)-1,4-diazabicyclo-[2.2.1] heptane dimaleate (Dabis maleate) and its uncharged tertiary amine a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51e72433bc8e34868912fab3ae8670ff
https://doi.org/10.1038/bjc.1990.53

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Design and synthesis of a nitrogen mustard derivative stabilized by apo-neocarzinostatin

Autor: Dek N Woolfson, Stephen Caddick, JA Hartley, Urbaniak, JP Bingham

Publikováno v: Journal of medicinal chemistry. 47(19)

Neocarzinostatin (NCS) is an antitumor antibiotic comprising a 1:1 protein-chromophore complex and exhibits cytotoxic action through DNA cleavage via H-abstraction. Cytotoxic activity resides with the chromophore 1 alone, while the protein (apoNCS) p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8893ad13a75e263c13e696e3ed8afa68
https://pubmed.ncbi.nlm.nih.gov/15341486

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Synthesis of new bifunctional compounds which selectively alkylate guanines in DNA

Autor: Nd, Henderson, Sm, Lacy, Hare Cc, O., Ja, Hartley, Siobhán McClean, Lp, Wakelin, Lr, Kelland, Dj, Robins

Publikováno v: Europe PubMed Central

The aim of this work was to develop new bifunctional alkylating agents which damage DNA in a selective manner. In order to extend our previously published work on conformationally restricted nitrogen mustards containing one piperidine ring, new bispi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::904ba457ec36ad6c6952407c84e018e9
https://pubmed.ncbi.nlm.nih.gov/9807160

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bcl-2 modulation of apoptosis induced by anticancer drugs: resistance to thymidylate stress is independent of classical resistance pathways

Autor: Tc, Fisher, Ae, Milner, Cd, Gregory, Al, Jackman, Gw, Aherne, Ja, Hartley, Caroline Dive, Ja, Hickman

Publikováno v: Europe PubMed Central

The hypothesis was tested that expression of bcl-2 could provide protection against apoptosis induced by cytotoxic drugs via a mechanism which was different from the classical determinants of drug resistance. Sensitivity and resistance to inhibitors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::daa014cdf0b2251aeff12d38212c2d57
https://pubmed.ncbi.nlm.nih.gov/8324744

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Targeting of tumor cells and DNA by a chlorambucil-spermidine conjugate

Autor: Jl, Holley, Mather A, Richard Wheelhouse, Pm, Cullis, Ja, Hartley, Jp, Bingham, Gm, Cohen

Publikováno v: Europe PubMed Central

Many tumor cells, including murine ADJ/PC6 plasmacytoma cells, possess an active energy dependent polyamine uptake system which selectively accumulates endogenous polyamines and structurally related compounds. We have attempted to target the cytotoxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8dd4b7a212ca36ee5c37562495ee839f
https://pubmed.ncbi.nlm.nih.gov/1638533

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Chemical, biochemical and pharmacological activity of the novel sterically hindered platinum co-ordination complex, cis-[amminedichloro(2-methylpyridine)] platinum(II) (AMD473)

Autor: Holford J, Raynaud F, Ba, Murrer, Keith Anthony Grimaldi, Ja, Hartley, Abrams M, Lr, Kelland

Publikováno v: Europe PubMed Central

cis-[Amminedichloro(2-methylpyridine)] platinum(II) (AMD473) is a novel sterically hindered anti-tumour compound designed to circumvent platinum drug resistance and is due to begin clinical trials in 1997. This paper reports the rationale behind the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1e8f264b0cbb7f4972f34cbee8d4f4f0
http://europepmc.org/abstract/med/9474239

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