Výsledky vyhledávání - "Ja, Decaprio"

Characterization of p16(INK4A) expression in multiple myeloma and plasma cell leukemia

Autor: Urashima M, Teoh G, Atsushi Ogata, Chauhan D, Sp, Treon, Sugimoto Y, Kaihara C, Matsuzaki M, Hoshi Y, Ja, Decaprio, Kc, Anderson

Publikováno v: Europe PubMed Central

Loss of p16(INK4A) (p16) expression is frequently associated with the development of epithelial and lymphoid malignancies. However, the frequency and significance of p16 abnormalities in multiple myeloma (MM) and the more aggressive phase of plasma c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4fb5120d01aea8c5459566f94a5ef925
https://pubmed.ncbi.nlm.nih.gov/9815612

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p16INK4A promotes differentiation and inhibits apoptosis of JKB acute lymphoblastic leukemia cells

Autor: Urashima M, Ja, Decaprio, Chauhan D, Teoh G, Atsushi Ogata, Sp, Treon, Hoshi Y, Kc, Anderson

Publikováno v: Europe PubMed Central

Homozygous p16(INK4A) (p16) gene deletion is frequent in primary tumor cells from acute lymphoblastic leukemia (ALL), suggesting that loss of p16 may be an important precursor to transformation in ALL. We have previously described JKB, a human ALL ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7d9b9c17bf69b9e99f553b2cc4b6bad7
https://pubmed.ncbi.nlm.nih.gov/9354681

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MDM2 protein overexpression promotes proliferation and survival of multiple myeloma cells

Autor: Teoh G, Urashima M, Atsushi Ogata, Chauhan D, Ja, Decaprio, Sp, Treon, Rl, Schlossman, Kc, Anderson

Publikováno v: Europe PubMed Central

The murine double minute 2 (MDM2) protein facilitates G1 to S phase transition by activation of E2F-1 and can enhance cell survival by suppressing wild-type p53 (wtp53) function. In this study, we examined MDM2 expression and function in multiple mye

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3b727c4c97cd2b54aca321ba352c5b1e
https://pubmed.ncbi.nlm.nih.gov/9292533

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A novel pre-B acute lymphoblastic leukemia cell line with chromosomal translocation between p16(INK4A)/p15(INK4B) tumor suppressor and immunoglobulin heavy chain genes: TGFbeta/IL-7 inhibitory signaling mechanism

Autor: Urashima M, Hoshi Y, Sugimoto Y, Kaihara C, Matsuzaki M, Chauhan D, Atsushi Ogata, Teoh G, Ja, Decaprio, Kc, Anderson

Publikováno v: Europe PubMed Central

p16 INK4A and/or p15 INK4B genes are frequently deleted in leukemias and other cancers. We have established a novel pre-B acute lymphoblastic leukemia (ALL) cell line (JKB2) with a chromosomal translocation between 9p2l and 14q32, on which p16INK4A/p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::87b2d1a538445a5043365babb85d1880
https://pubmed.ncbi.nlm.nih.gov/8847892

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Interleukin-6 promotes multiple myeloma cell growth via phosphorylation of retinoblastoma protein

Autor: Urashima M, Atsushi Ogata, Chauhan D, Mb, Vidriales, Teoh G, Hoshi Y, Rl, Schlossman, Ja, Decaprio, Kc, Anderson

Publikováno v: Europe PubMed Central

Interleukin-6 (IL-6) mediates autocrine and paracrine growth of multiple myeloma (MM) cells and inhibits tumor cell apoptosis. Abnormalities of retinoblastoma protein (pRB) and mutations of RB gene have been reported in up to 70% of MM patients and 8

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::40199cd947e02102d6d7a8afb8e63cca
http://europepmc.org/abstract/med/8822942

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