Inhibition of T cell activation by a monoclonal antibody reactive against the alpha 3 domain of human MHC class I molecules

Autor: Dm, Smith, Ja, Bluestone, Dr, Jeyarajah, Mh, Newberg, Victor Engelhard, Jr, Thistlethwaite, Es, Woodle

Publikováno v: Europe PubMed Central

A long term goal of investigators working in our laboratory has been to develop new mAbs for use as immunosuppressive agents. As a means toward achieving this goal, several new mAbs (hybridomas) have been developed by screening fusions for supernatan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d69c42e1fe2362d4105a75900b7fa27f
https://pubmed.ncbi.nlm.nih.gov/7913109

Peripheral murine CD3+, CD4-, CD8- T lymphocytes express novel T cell receptor gamma delta structures

Autor: Rq, Cron, Frits Koning, Wl, Maloy, Pardoll D, Je, Coligan, Ja, Bluestone

Publikováno v: Europe PubMed Central

A mAb directed against the CD3 molecule was used to identify a subset of CD3+, CD4-, CD8- T cells previously undefined in the peripheral lymphoid organs of the mouse. Biochemical analysis of CD3+, CD4-, CD8- splenocytes revealed that the vast majorit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::87c1151f05e24c18d3a02409652a5387
http://europepmc.org/abstract/med/3260917

Analysis of T-cell receptor gamma chain expression in the thymus

Autor: Dm, Pardoll, Andrew Lew, Wl, Maloy, Bj, Fowlkes, Kruisbeek A, Ja, Bluestone, Rh, Schwartz, Je, Coligan

Publikováno v: Europe PubMed Central

While much is known about the structure and function of the T-cell receptor (TCR) alpha beta heterodimer, information has just begun to emerge about the gamma protein, the product of a third rearranging T-cell receptor gene. We describe the use of an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c88096b12c093cea2827b75c120aadf7
http://europepmc.org/abstract/med/3453602

Somatic cell variants express altered H-2Kb allodeterminants recognized by cytolytic T cell clones

Autor: Ja, Bluestone, Langlet C, Ss, Geier, Sg, Nathenson, Foo M, Anne-Marie Schmitt-Verhulst

Publikováno v: Europe PubMed Central

The present studies have made use of in vitro derived H-2Kb mutants to analyze the fine specificity of alloreactive cytotoxic T lymphocytes (CTL). The variants were derived by negatively selecting mutagenized tumor cells with a monoclonal anti-H-2Kb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2efbe6d20ec2bfdd42a79c54cf496328
http://europepmc.org/abstract/med/2426358

Rebalancing the Immune System to Treat Type 1 Diabetes.

Autor: Muller YD; Division of Immunology and Allergy, Department of Medicine, Lausanne University Hospital and University of Lausanne, 1005 Lausanne, Switzerland.; Center for Human Immunology Lausanne, Lausanne University Hospital and University of Lausanne, 1005 Lausanne, Switzerland., Ho P; Diabetes Center, University of California San Francisco, San Francisco, California 94143, USA., Bluestone JA; Diabetes Center, University of California San Francisco, San Francisco, California 94143, USA.; Sonoma Biotherapeutics, South San Francisco, California 94080, USA., Tang Q; Diabetes Center, University of California San Francisco, San Francisco, California 94143, USA Qizhi.Tang@ucsf.edu.; Department of Surgery, Division of Transplantation, University of California San Francisco, San Francisco, California 94143, USA.; Gladstone UCSF Institute of Genome Immunology, San Francisco, California 94158, USA.

Publikováno v: Cold Spring Harbor perspectives in medicine [Cold Spring Harb Perspect Med] 2024 Sep 16. Date of Electronic Publication: 2024 Sep 16.