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pro vyhledávání: '"JZL195"'
Akademický článek
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Autor:
Malinowska, Marek Toczek, Piotr Ryszkiewicz, Patryk Remiszewski, Eberhard Schlicker, Anna Krzyżewska, Hanna Kozłowska, Barbara
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 13; Pages: 10942
The enhancement of the endocannabinoid tone might have a beneficial influence on hypertension. Polypharmacology proposes multi-target-directed ligands (MTDLs) as potential therapeutic agents for the treatment of complex diseases. In the present paper
Akademický článek
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Publikováno v:
Journal of Experimental Biology. 224
The fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) enzymes are the predominant catabolic regulators of the major endocannabinoids (eCBs) anadamide (AEA) and 2-arachidonoylglycerol (2-AG), respectively. The expression and roles o
Autor:
Benjamin F. Cravatt, David G. Stouffer, Marisa Roberto, Ilham Polis, Rémi Martin-Fardon, Loren H. Parsons, Antonia Serrano, Francisco Javier Pavón, Fernando Rodríguez de Fonseca
Publikováno v:
Neurobiology of Stress
Neurobiology of Stress, Vol 14, Iss, Pp 100293-(2021)
Neurobiology of Stress, Vol 14, Iss, Pp 100293-(2021)
The endocannabinoid system is involved in the regulation of the stress response, but the relative contribution of N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG) and their mechanisms have to be elucidated. In this study, we compare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1136f4b77fb6282ae93751d3737c6301
https://hdl.handle.net/10668/3827
https://hdl.handle.net/10668/3827
Autor:
Bruna Pascarelli Pedrico do Nascimento, Marcia Ivany Silva de Serro-Azul, Miriam O. Ribeiro, Geraldo Barbosa, Roberta Monterazzo Cysneiros, Alexandre Arnold, Fernanda Beraldo Lorena, Fernanda Teixeira Ribeiro
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 14 (2020)
Frontiers in Behavioral Neuroscience
Frontiers in Behavioral Neuroscience
The early life status epilepticus (SE) causes high anxiety and chronic socialization abnormalities, revealed by a low preference for social novelty and deficit in social discrimination. This study investigated the involvement of the endocannabinoid s
Autor:
Li Tong, Jingjing Liu, Lize Xiong, Jingyi Wang, Haruki Higashimori, Yongjie Yang, Hailong Dong, Feng Wang, Xia Zhang, Jing Han
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 39:1122-1137
Ischemia not only activates cell death pathways but also triggers endogenous protective mechanisms. However, it is largely unknown what is the essence of the endogenous neuroprotective mechanisms induced by preconditioning. In this study we demonstra
Publikováno v:
British Journal of Pharmacology. 174:3780-3789
Background and Purpose Endocannabinoids and opioids play a vital role in mediating pain-induced analgesia. The specific effects of these compounds within the orofacial region are largely unknown. In this study, we tried to determine whether an increa
Autor:
Bin Dong, Thomas B. Cooper, Borehalli M. Shilpa, Shan Xie, Mihran J. Bakalian, Arjun Goyal, Raymond F. Suckow, Victoria Arango, K. Yaragudri Vinod, J. John Mann, Relish Shah
Publikováno v:
J Psychiatr Res
Major depressive disorder (MDD) is common, often under-treated and a leading cause of disability and mortality worldwide. The causes of MDD remain unclear, including the role of the endocannabinoid system. Intriguingly, the prevalence of depression i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3517caff3931ed32fe4759e985887ec8
https://europepmc.org/articles/PMC6916267/
https://europepmc.org/articles/PMC6916267/
Publikováno v:
Journal of neurochemistryReferences. 152(1)
It is thought that endogenous cannabinoids have a role in the analgesia induced by specific forms of stress. We examined if the role of endogenous cannabinoids is also dependent upon the mode of nociception, and whether this could be altered by drugs