Zobrazeno 1 - 10
of 130
pro vyhledávání: '"JWH133"'
Publikováno v:
Heliyon, Vol 10, Iss 23, Pp e40806- (2024)
Background: Cannabinoid administration has demonstrated promising anti-tumor effects for glioblastoma (GBM) by inhibiting glioma cell proliferation and inducing glioma cell death. However, the impact of cannabinoids and endocannabinoid receptors on i
Externí odkaz:
https://doaj.org/article/0b5950c263204375b14262fd345353ef
Autor:
Xiao Wu, Lina Chen, Yiju Cheng, Yuquan Zhang, Wenting Yang, Lin Pan, Chenkun Fu, Honglan Zhu, Menglin Zhang
Publikováno v:
BMC Pulmonary Medicine, Vol 23, Iss 1, Pp 1-9 (2023)
Abstract Background The combination of the endocannabinoid system (ECS) and the type 2 cannabinoid receptor (CB2R) can activate various signal pathways, leading to distinct pathophysiological roles. This interaction has gained significant attention i
Externí odkaz:
https://doaj.org/article/f0bca9fb43c84a3ba943d7ae985fff0a
Publikováno v:
Exploration of Neuroprotective Therapy, Vol 3, Iss 5, Pp 258-267 (2023)
Aim: The sequential phosphorylation of mitogen-activated protein (MAP) kinases MEK-ERK is the most relevant cellular signaling pathway. This study quantified the parallel in vivo regulation of brain phosphorylation-MEK1/2 (p-MEK1/2) to p-ERK1/2 by me
Externí odkaz:
https://doaj.org/article/df8d26269b3d437f9ba880e74e25584b
Akademický článek
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Autor:
Niraj Kumar Jha, Charu Sharma, Mohamed Fizur Nagoor Meeran, Saurabh Kumar Jha, Vivek Dhar Dwivedi, Piyush Kumar Gupta, Abhijit Dey, Kavindra Kumar Kesari, Shreesh Ojha
Publikováno v:
Immuno, Vol 1, Iss 3, Pp 285-304 (2021)
The COVID-19 pandemic, caused by SARS-CoV-2, is a deadly disease affecting millions due to the non-availability of drugs and vaccines. The majority of COVID-19 drugs have been repurposed based on antiviral, immunomodulatory, and antibiotic potential.
Externí odkaz:
https://doaj.org/article/d0dd19143da84d7cb62d904660c57dbd
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Several studies have shown that the G-protein coupled cannabinoid receptor CB2 and its interaction partner p62 are molecularly involved in bone remodeling processes. Pharmacological activation of the CB2 receptor enhanced bone volume in postmenopausa
Externí odkaz:
https://doaj.org/article/dda08752f5ae4acca6f371d922eee330
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
The endocannabinoid system has attracted attention as a pharmacological target for several pathological conditions. Cannabinoid (CB2)-selective agonists have been the focus of pharmacological studies because modulation of the CB2 receptor (CB2R) can
Externí odkaz:
https://doaj.org/article/dedcde7870a14d5e952df396dbfbcee6
Publikováno v:
Open Life Sciences, Vol 14, Iss 1, Pp 363-375 (2019)
It has been reported that endocannabinoid receptor type 2 (CB2) agonist JWH133 inhibits the growth of C6 glioma cells, but the underlying mechanism has not yet been fully elucidated. We showed that JWH133 inhibited C6 cells growth, reduced cAMP produ
Externí odkaz:
https://doaj.org/article/1a343dc18ba645549e7074d8dcab68d7
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Enhancing the therapeutic efficacy of anti-tumor drugs is essential for cancer management. Although cannabinoid receptor 2 (CB2R) stimulation exerts anti-tumor action in glioma cells by regulating cellular proliferation, differentiation, or apoptosis
Externí odkaz:
https://doaj.org/article/d006f36e219a4810ace792f1b5fe72bc
Akademický článek
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